TXK - TXK tyrosine kinase Gene

中文名称：TXK 酪氨酸激酶

种属: Homo sapiens

同用名: RLK; TKL; BTKL; PTK4; PSCTK5

基因 ID: 7294 | 基因类型: protein coding

关于 TXK

Cytogenetic location: 4p12 Genomic coordinates (GRCh38): 4:48,066,393-48,134,250 (from NCBI)

This gene has 6 transcripts (splice variants), 117 orthologues and 32 paralogues. Broad expression in lymph node (RPKM 5.7), spleen (RPKM 3.3) and 15 other tissues.

功能概要

预计可启用非跨膜蛋白酪氨酸激酶活性。参与干扰素-γ介导的信号通路的正向调控；大分子代谢过程的正向调控；和蛋白质自身磷酸化。位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of macromolecule metabolic process; and protein autophosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TXK 基因产物(1)

mRNA	Protein	Name
NM_003328.3	NP_003319.2	tyrosine-protein kinase TXK

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17177976	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	11859127	GOA
involved in positive regulation of type II interferon production	IDA IDA: 通过直接分析推断	10523612	GOA
involved in positive regulation of type II interferon-mediated signaling pathway	IDA IDA: 通过直接分析推断	11859127	GOA
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	12081135	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	17177976	GOA
involved in regulation of gene expression	IDA IDA: 通过直接分析推断	11859127	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10523612	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10523612	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TXK 蛋白结构

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
527 a.a.

蛋白主名

其他名称

tyrosine-protein kinase TXK

PTK4 protein tyrosine kinase 4

TXK 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TXK	P42681	ZNF792	Homo sapiens	Q3KQV3	Validated Y2H	32296183
种属内	TXK	P42681	ZNF792	Homo sapiens	Q3KQV3	Y2H Array	32296183
种属内	TXK	P42681	ZNF792	Homo sapiens	Q3KQV3	Y2H Prey Pooling	32296183
种属内	TXK	P42681	DOK2	Homo sapiens	O60496	Y2H Prey Pooling	32296183
种属内	TXK	P42681	DOK2	Homo sapiens	O60496	Y2H Array	32296183
种属内	TXK	P42681	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
种属内	TXK	P42681	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
种属内	TXK	P42681	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
种属内	TXK	P42681	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
种属内	TXK	P42681	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
种属内	TXK	P42681	CBY2	Homo sapiens	Q8NA61-2	Validated Y2H	32296183
种属内	TXK	P42681	RBAK	Homo sapiens	Q9NYW8	Validated Y2H	32296183
种属内	TXK	P42681	RBAK	Homo sapiens	Q9NYW8	Y2H Array	32296183
种属内	TXK	P42681	RBAK	Homo sapiens	Q9NYW8	Y2H Prey Pooling	32296183
种属内	TXK	P42681	GRB10	Homo sapiens	Q13322-4	Validated Y2H	32296183
种属内	TXK	P42681	GRB10	Homo sapiens	Q13322-4	Y2H Prey Pooling	32296183
种属内	TXK	P42681	GRB10	Homo sapiens	Q13322-4	Y2H Array	32296183
种属内	TXK	P42681	KIT	Homo sapiens	P10721	FPS	24728074
种属内	TXK	P42681	STAP2	Homo sapiens	Q9UGK3	Y2H Array	32296183
种属内	TXK	P42681	STAP2	Homo sapiens	Q9UGK3	Validated Y2H	32296183
种属内	TXK	P42681	STAP2	Homo sapiens	Q9UGK3	Y2H Prey Pooling	32296183
种属内	TXK	P42681	IKZF4	Homo sapiens	Q9H2S9	Validated Y2H	32296183
种属内	TXK	P42681	IKZF4	Homo sapiens	Q9H2S9	Y2H Array	32296183
种属内	TXK	P42681	IKZF4	Homo sapiens	Q9H2S9	Y2H Prey Pooling	32296183
种属内	TXK	P42681	JRK	Homo sapiens	O75564-2	Y2H Array	32296183
种属内	TXK	P42681	JRK	Homo sapiens	O75564-2	Y2H Prey Pooling	32296183
种属内	TXK	P42681	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
种属内	TXK	P42681	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
种属内	TXK	P42681	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
种属内	TXK	P42681	SOCS6	Homo sapiens	O14544	Y2H Array	32296183
种属内	TXK	P42681	SOCS6	Homo sapiens	O14544	Y2H Prey Pooling	32296183
种属内	TXK	P42681	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	32296183
种属内	TXK	P42681	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	32296183
种属内	TXK	P42681	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	32296183
种属内	TXK	P42681	GRB2	Homo sapiens	P62993	Validated Y2H	32296183
种属内	TXK	P42681	ZNF835	Homo sapiens	Q9Y2P0	Y2H Array	32296183
种属内	TXK	P42681	ZNF835	Homo sapiens	Q9Y2P0	Y2H Prey Pooling	32296183
种属内	TXK	P42681	ZNF835	Homo sapiens	Q9Y2P0	Validated Y2H	32296183
种属内	TXK	P42681	ZNF587	Homo sapiens	Q96SQ5	Y2H Prey Pooling	32296183
种属内	TXK	P42681	ZNF587	Homo sapiens	Q96SQ5	Y2H Array	32296183
种属内	TXK	P42681	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
种属内	TXK	P42681	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	32296183
种属内	TXK	P42681	NCK2	Homo sapiens	O43639	Y2H Array	32296183
种属内	TXK	P42681	SOCS3	Homo sapiens	O14543	Y2H Array	32296183
种属内	TXK	P42681	SOCS3	Homo sapiens	O14543	Y2H Prey Pooling	32296183
种属内	TXK	P42681	DUSP6	Homo sapiens	Q16828	Validated Y2H	32296183
种属内	TXK	P42681	DUSP6	Homo sapiens	Q16828	Y2H Array	32296183
种属内	TXK	P42681	DUSP6	Homo sapiens	Q16828	Y2H Prey Pooling	32296183
种属内	TXK	P42681	TNS4	Homo sapiens	Q8IZW8	Validated Y2H	32296183
种属内	TXK	P42681	TNS4	Homo sapiens	Q8IZW8	Y2H Array	32296183
种属内	TXK	P42681	TNS4	Homo sapiens	Q8IZW8	Y2H Prey Pooling	32296183
种属内	TXK	P42681	CRK	Homo sapiens	P46108	Y2H Prey Pooling	32296183
种属内	TXK	P42681	CRK	Homo sapiens	P46108	Validated Y2H	32296183
种属内	TXK	P42681	CRK	Homo sapiens	P46108	Y2H Array	32296183
种属内	TXK	P42681	PIK3R1	Homo sapiens	P27986-2	Y2H Prey Pooling	32296183
种属内	TXK	P42681	PIK3R1	Homo sapiens	P27986-2	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Agammaglobulinemia

Hypogammaglobulinemia	Ighm
Mu Heavy Chain Deficiency	Mu-Heavy Chain Disease
Mu-Hcd	Mu-Chain Disease

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Agammaglobulinemia, X-Linked

X-Linked Agammaglobulinemia	XLA
Bruton Type Agammaglobulinemia	Bruton'S Agammaglobulinemia
Bruton-Type Agammaglobulinemia	Agmx1
Imd1	Agammaglobulinemia, X-Linked 1
Btk-Deficiency	Agammaglobulinemia
Hypogammaglobulinemia	Agammaglobulinemia, X-Linked, Type 1
Immunodeficiency 1	Bruton Agammaglobulinemia Tyrosine Kinase Deficiency
Bruton Disease	Bruton'S Agammaglobulinaemia
Bruton'S Sex-Linked Agammaglobulinemia	Bruton'S Type Agammaglobulinemia
Btk Deficiency	Agammaglobulinemia, Btk
Agammaglobulinemia, Bruton Tyrosine Kinase	Congenital Agammaglobulinemia
Immunodeficiency Type 1	X-Linked Agammaglobulinemia Type 1

Immunodeficiency 17

IMD17	Cd3-Gamma Deficiency
Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive	Combined Immunodeficiency Due To Cd3gamma Deficiency
Immunodeficiency 17, Cd3 Gamma Deficient	Cd3gamma Deficiency
Immunodeficiency, Type 17

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-10644	Lck inhibitor 2	Inhibitor	99.81%	否
HY-145373	BMS-986143	Inhibitor	/	否
HY-RS15285	TXK Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-D2415	BODIPY-FL staurosporine		/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TXK	VGNC	VGNC:48005
Bos taurus	TXK	VGNC	VGNC:36529
Mus musculus	TXK	MGD	MGI:102960
Felis catus	TXK	VGNC	VGNC:66719
Macaca mulatta	TXK	VGNC	VGNC:78678
Rattus norvegicus	TXK	RGD	RGD:1306481
Others	TXK	NCBI

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