2. Gene
  3. BACH1 - BTB domain and CNC homolog 1 Gene

BACH1 - BTB domain and CNC homolog 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BTB 域和 CNC 同系物 1

种属: Homo sapiens

同用名: BACH-1; BTBD24

基因 ID: 571 | 基因类型: protein coding

关于 BACH1

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:29,298,922-29,361,894 (from NCBI)

This gene has 13 transcripts (splice variants), 257 orthologues and 54 paralogues. Ubiquitous expression in bone marrow (RPKM 19.7), placenta (RPKM 15.8) and 25 other tissues.

功能概要

该基因编码的转录因子属于 cap'n'collar 型碱性区域亮氨酸拉链因子家族 (CNC-bZip) 。编码的蛋白质包含广泛的复合物、tramtrack、bric-a-brac/poxvirus 和锌指 (BTB/POZ) 结构域，这是 CNC-bZip 家族成员的非典型结构域。这些 BTB/POZ 结构域促进蛋白质-蛋白质相互作用以及同源和/或异源寡聚体的形成。当这种编码的蛋白质与 MafK 形成异二聚体时，它会作为 Maf 识别元件 (MARE) 的阻遏物发挥作用并抑制转录。已为该基因鉴定出多个选择性剪接的转录物变体。[RefSeq 提供，2009 年 5 月]

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]

BACH1 基因产物(2)

mRNA Protein Name
NM_001186.4 NP_001177.1 transcription regulator protein BACH1
NM_206866.3 NP_996749.1 transcription regulator protein BACH1

BACH1 蛋白结构

BTB

BTB: BTB/POZ domain (24 - 127)

bZIP_Maf

bZIP_Maf: bZIP Maf transcription factor (531 - 607)

  • 0
  • 200
  • 400
  • 600
  • 736 a.a.
蛋白主名 其他名称

transcription regulator protein BACH1

BTB and CNC homology 1, basic leucine zipper transcription factor 1

BACH1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra BACH1 O14867 ATF2 Homo sapiens P15336
Anti Tag CoIP
33961781
Intra BACH1 O14867 VHL Homo sapiens P40337-2
Y2H Pooling
32814053
Intra BACH1 O14867 VHL Homo sapiens P40337-2
Validated Y2H
32814053
Intra BACH1 O14867 VHL Homo sapiens P40337-2
Y2H Array
32814053
Intra BACH1 O14867 PRKN Homo sapiens O60260-5
Validated Y2H
32814053
Intra BACH1 O14867 PRKN Homo sapiens O60260-5
Y2H Array
32814053
Intra BACH1 O14867 PRKN Homo sapiens O60260-5
Y2H Pooling
32814053
Intra BACH1 O14867 DYNLL1 Homo sapiens P63167
Y2H Fragment Pooling
35914814
Intra BACH1 O14867 MAFB Homo sapiens Q9Y5Q3
Peptide Array
20102225
Intra BACH1 O14867 MAFB Homo sapiens Q9Y5Q3
Anti Tag CoIP
33961781
Intra BACH1 O14867 MAFG Homo sapiens O15525
Peptide Array
20102225
Intra BACH1 O14867 MAFG Homo sapiens O15525
Anti Tag CoIP
33961781
Intra BACH1 O14867 MAFG Homo sapiens O15525
Anti Tag CoIP
26496610
Intra BACH1 O14867 MAFG Homo sapiens O15525
Anti Tag CoIP
28514442
Intra BACH1 O14867 MAFG Homo sapiens O15525
FRET
23661758
Intra BACH1 O14867 MAFF Homo sapiens Q9ULX9
FRET
23661758
Intra BACH1 O14867 MAFF Homo sapiens Q9ULX9
Anti Tag CoIP
26496610
Intra BACH1 O14867 MAFF Homo sapiens Q9ULX9
Anti Tag CoIP
33961781
Intra BACH1 O14867 MAFF Homo sapiens Q9ULX9
Anti Tag CoIP
28514442
Intra BACH1 O14867 ATF7 Homo sapiens P17544
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153040 HPPE Inhibitor 99.81% 否
HY-111827 S-1-Propenyl-L-cysteine 99.81% 否
HY-W583212 Zn(II) Mesoporphyrin IX / 否
HY-RS01339 BACH1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-167874 ASP-8731 / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus BACH1 MGD MGI:894680
Felis catus BACH1 VGNC VGNC:69035
Macaca mulatta BACH1 VGNC VGNC:70217
Rattus norvegicus BACH1 RGD RGD:1306693
Bos taurus BACH1 VGNC VGNC:26402
Canis familiaris BACH1 VGNC VGNC:38360
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