2. Gene
  3. MAFB - MAF bZIP transcription factor B Gene

MAFB - MAF bZIP transcription factor B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MAF bZIP 转录因子 B

种属: Homo sapiens

同用名: KRML; MCTO; DURS3

基因 ID: 9935 | 基因类型: protein coding

关于 MAFB

Cytogenetic location: 20q12 Genomic coordinates (GRCh38): 20:40,685,848-40,689,236 (from NCBI)

This gene has 1 transcript (splice variant), 245 orthologues, 6 paralogues and is associated with 52 phenotypes.

功能概要

该基因编码的蛋白质是一种基本的亮氨酸拉链 (bZIP) 转录因子，在谱系特异性造血功能的调节中起着重要作用。编码的核蛋白抑制 ETS1 介导的骨髓细胞中红系特异性基因的转录。该基因不含内含子。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008]

MAFB 基因产物(1)

mRNA Protein Name
NM_005461.5 NP_005452.2 transcription factor MafB
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20102225 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20102225 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of erythrocyte differentiation IDA
IDA: 通过直接分析推断
8620536 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
27181683 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IPI
IPI: 通过物理相互作用推断
23661758 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
27208706 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAFB 蛋白结构

Maf_N

Maf_N: Maf N-terminal region (80 - 114)

bZIP_Maf

bZIP_Maf: bZIP Maf transcription factor (211 - 301)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
蛋白主名 其他名称

transcription factor MafB

Kreisler maf-related leucine zipper homolog

MAFB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MAFB Q9Y5Q3 BACH1 Homo sapiens O14867
Anti Tag CoIP
33961781
Intra MAFB Q9Y5Q3 BACH1 Homo sapiens O14867
FRET
23661758
Intra MAFB Q9Y5Q3 BACH1 Homo sapiens O14867
Peptide Array
20102225
Intra MAFB Q9Y5Q3 IRF3 Homo sapiens Q14653
Anti Bait CoIP
20581830
Intra MAFB Q9Y5Q3 MAF Homo sapiens O75444
FRET
23661758
Intra MAFB Q9Y5Q3 MAFB Homo sapiens Q9Y5Q3
FRET
23661758
Intra MAFB Q9Y5Q3 MAFB Homo sapiens Q9Y5Q3
Y2H Array
20211142
Intra MAFB Q9Y5Q3 MAFB Homo sapiens Q9Y5Q3
Peptide Array
20102225
Intra MAFB Q9Y5Q3 HBZ Human T-cell leukemia virus 1 P0C746
Peptide Array
20102225
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Multicentric Carpotarsal Osteolysis Syndrome

Multicentric Carpo-Tarsal Osteolysis With Or Without Nephropathy

MCTO

Osteolysis, Hereditary, Of Carpal Bones With Or Without Nephropathy

Idiopathic Multicentric Osteolysis With Or Without Nephropathy

Autosomal Dominant Multicentric Osteolysis

Hereditary Osteolysis Of Carpal Bones With Or Without Nephropathy

Multicentric Osteolysis, Autosomal Dominant

Multicentric Osteolysis Nephropathy

Osteolysis, Carpotarsal, Multicentric Syndrome

Lytic Lesion
Duane Retraction Syndrome 3 With Or Without Deafness

DURS3

Duane Retraction Syndrome 3

Duane Retraction Syndrome With Congenital Deafness

Drs With Deafness

Drs With Hearing Loss

Durs With Deafness

Durs With Hearing Loss

Duane Retraction Syndrome With Congenital Hearing Loss
Duane Retraction Syndrome 2

DURS2

Duane Retraction Syndrome, Type 2
Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome

Duane'S Syndrome

Duane Syndrome

Isolated Duane Retraction Syndrome

Co-Contractive Retraction Syndrome

Duane Anomaly, Isolated

Ocular Retraction Syndrome

Drs

Durs
Fibrosarcoma

Neoplasms, Fibrous Tissue

Fibrocytic Tumor

Fibrosarcoma Of Soft Tissue

Fibrous Tissue Neoplasm
Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis

Juvenile Chronic Polyarthritis

Monarticular Juvenile Rheumatoid Arthritis

Pauciarticular Juvenile Arthritis

Still'S Disease

Systemic Juvenile Rheumatoid Arthritis

Juvenile Chronic Arthritis

Acute Juvenile Rheumatoid Arthritis

Pauciarticular Onset Juvenile Chronic Arthritis

Arthritis, Juvenile Rheumatoid

Jia

Jra

Juvenile Ra

Arthritis Juvenile Rheumatoid

Stills Disease

Juvenile Arthritis

Acute Polyarticular Juvenile Rheumatoid Arthritis

Pauciarticular Juvenile Rheumatoid Arthritis

Rheumatoid Arthritis, Systemic Juvenile
Amblyopia

Lazy Eye
Monoclonal Gammopathy Of Uncertain Significance

Monoclonal Gammopathy Of Undetermined Significance

Mgus

Mgus - [Monoclonal Gammopathy Of Undetermined Significance]

Monoclonal Gammopathy Nos

Iga Gammopathy

Monoclonal Gammoglobulinopathy
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Smoldering Myeloma
Blood Protein Disease

Blood Protein Disorders

Blood Protein Disorder
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
Plasma Cell Leukemia

Plasma Cell Leukaemia

Leukemia, Plasma Cell

Plasmacytic Leukaemia

Plasmacytic Leukemia

Pcl

Plasma Cell Leukaemia, Nos

Leukemic Plasma Cell

Plasma Cell Leukaemia Without Mention Of Remission
Theileriasis

Theileriosis

Infection By Theileria
Pancreatic Agenesis

Partial Pancreatic Agenesis

Congenital Pancreatic Agenesis

Partial Agenesis Of The Pancreas

Agenesis, Pancreatic

Pancreatic Agenesis, Congenital
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Orofacial Cleft

Cleft, Orofacial
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07959 MAFB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MAFB VGNC VGNC:67982
Canis familiaris MAFB VGNC VGNC:54653
Macaca mulatta MAFB VGNC VGNC:74419
Bos taurus MAFB VGNC VGNC:31139
Rattus norvegicus MAFB RGD RGD:2982
Mus musculus MAFB MGD MGI:104555
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