2. Gene
  3. ATF3 - activating transcription factor 3 Gene

ATF3 - activating transcription factor 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：激活转录因子 3

种属: Homo sapiens

基因 ID: 467 | 基因类型: protein coding

关于 ATF3

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,565,407-212,620,777 (from NCBI)

This gene has 11 transcripts (splice variants), 220 orthologues and 8 paralogues. Ubiquitous expression in gall bladder (RPKM 38.3), liver (RPKM 37.5) and 23 other tissues.

功能概要

该基因编码哺乳动物激活转录因子/cAMP 反应元件结合 (CREB) 蛋白转录因子家族的成员。该基因由多种信号诱导，包括癌细胞遇到的许多信号，并参与细胞应激反应的复杂过程。已发现该基因编码不同异构体的多个转录变体。该基因的选择性剪接可能在靶基因的调节中具有重要的生理学意义。[RefSeq 提供，2011 年 4 月]

This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by Cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]

ATF3 基因产物(6)

mRNA Protein Name
NM_001030287.4 NP_001025458.1 cyclic AMP-dependent transcription factor ATF-3 isoform 1
NM_001040619.3 NP_001035709.1 cyclic AMP-dependent transcription factor ATF-3 isoform 2
NM_001206484.3 NP_001193413.2 cyclic AMP-dependent transcription factor ATF-3 isoform 3
NM_001206486.2 NP_001193415.1 cyclic AMP-dependent transcription factor ATF-3 isoform 5
NM_001206488.3 NP_001193417.2 cyclic AMP-dependent transcription factor ATF-3 isoform 3
NM_001674.4 NP_001665.1 cyclic AMP-dependent transcription factor ATF-3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
16300731 GOA
enables DNA-binding transcription factor activity IGI
IGI: 通过遗传相互作用推断
24939851 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
8622660 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
2516827 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18255255 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10327051 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
8622660 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
8622660 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
24939851 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7515060 GOA
involved in positive regulation of TRAIL-activated apoptotic signaling pathway IMP
IMP: 通过突变表型推断
24939851 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16300731 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8622660 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
24939851 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CHOP-ATF3 complex IDA
IDA: 通过直接分析推断
8622660 GOA
part of RNA polymerase II transcription regulator complex IPI
IPI: 通过物理相互作用推断
20102225 GOA
located in nucleus IDA
IDA: 通过直接分析推断
7515060 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATF3 蛋白结构

bZIP_1

bZIP_1: bZIP transcription factor (84 - 141)

  • 0
  • 100
  • 181 a.a.
蛋白主名 其他名称

cyclic AMP-dependent transcription factor ATF-3

cAMP-dependent transcription factor ATF-3

ATF3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ATF3 P18847 BATF3 Homo sapiens Q9NR55
FRET
23661758
种属内
ATF3 P18847 BATF3 Homo sapiens Q9NR55
Y2H Array
20211142
种属内
ATF3 P18847 ATF2 Homo sapiens P15336
FRET
23661758
种属内
ATF3 P18847 ATF2 Homo sapiens P15336
Y2H Array
20211142
种属内
ATF3 P18847 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
种属内
ATF3 P18847 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
种属内
ATF3 P18847 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
种属内
ATF3 P18847 DCTN1 Homo sapiens Q14203-5
Validated Y2H
32814053
种属内
ATF3 P18847 DCTN1 Homo sapiens Q14203-5
Y2H Pooling
32814053
种属内
ATF3 P18847 DCTN1 Homo sapiens Q14203-5
Y2H Array
32814053
种属内
ATF3 P18847 JUND Homo sapiens P17535
Pull Down
30833792
种属内
ATF3 P18847 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
种属内
ATF3 P18847 TARDBP Homo sapiens Q13148
Y2H Array
32814053
种属内
ATF3 P18847 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
种属内
ATF3 P18847 ATF4 Homo sapiens P18848
FRET
23661758
种属内
ATF3 P18847 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
种属内
ATF3 P18847 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
种属内
ATF3 P18847 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
种属内
ATF3 P18847 NFATC1 Homo sapiens O95644
TAP
25609649
种属内
ATF3 P18847 FHL2 Homo sapiens Q14192
Y2H
18255255
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
MAPPIT
31467278
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
BRET
37398436
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
FRET
23661758
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
BRET
29997244
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
Y2H Array
20211142
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
SLC
31467278
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
Complementation
31467278
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
Lumier
29997244
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
BFG-2H
27107012
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
Lumier
37398436
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
Peptide Array
20102225
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
Y2H Array
31467278
种属内
ATF3 P18847 DDIT3 Homo sapiens P35638
Lumier
32814053
种属内
ATF3 P18847 MAFF Homo sapiens Q9ULX9
FRET
23661758
种属内
ATF3 P18847 CEBPG Homo sapiens P53567
FRET
23661758
种属内
ATF3 P18847 CEBPG Homo sapiens P53567
Y2H Array
20211142
种属内
ATF3 P18847 CEBPG Homo sapiens P53567
Peptide Array
20102225
种属内
ATF3 P18847 JUNB Homo sapiens P17275
Pull Down
30833792
种属内
ATF3 P18847 BATF Homo sapiens Q16520
FRET
23661758
种属内
ATF3 P18847 ATF7 Homo sapiens P17544
Pull Down
30833792
种属内
ATF3 P18847 JUN Homo sapiens P05412
FRET
23661758
种属内
ATF3 P18847 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
种属内
ATF3 P18847 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
种属内
ATF3 P18847 ATXN1 Homo sapiens P54253
Y2H Array
32814053
种属内
ATF3 P18847 SNCA Homo sapiens P37840
Validated Y2H
32814053
种属内
ATF3 P18847 SNCA Homo sapiens P37840
Y2H Array
32814053
种属内
ATF3 P18847 SNCA Homo sapiens P37840
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypospadias

Hypospadias Familial

Familial Hypospadias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Pelvic Organ Prolapse

Rectal Prolapse

Pelvic Organ Prolapse, Susceptibility To, 1

Pelvic Organ Prolapse, Susceptibility To

Prolapse Of Vagina And Rectum

Vaginal Prolapse

Pelvic Organ Prolapse 1

Procidentia, Rectum

Prolapse Of Rectal Mucosa

Procidentia Of Rectum

Rectal Mucosa Prolapse

Rectum Prolapse

Procidentia Rectum

Rp - [Rectal Prolapse]

Male Proctocele

Male Rectocele

Proctoptosis

Female Genital Prolapse

Female Prolapse

Incompetence Of Pelvic Fundus

Relaxation Of Perineum

Deficiency Of Perineum
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Plantar Fascial Fibromatosis

Dupuytren'S Contracture Of Foot

Ledderhose'S Disease

Fibromatosis, Plantar

Ledderhose Disease
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-151923 ATF3 inducer 1 Inhibitor 99.50% 否
HY-153347 JY-2 99.75% 否
HY-12756A E6446 dihydrochloride 99.96% 否
HY-12756 E6446 ≥98.0% 否
HY-RS01129 ATF3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-162384 EPIC-0628 Inhibitor 98.93% 否
HY-155158 Anticancer agent 147 Inducer / 否
HY-163319 NCA029 / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ATF3 MGD MGI:109384
Bos taurus ATF3 VGNC VGNC:26241
Macaca mulatta ATF3 VGNC VGNC:70170
Rattus norvegicus ATF3 RGD RGD:2165
Felis catus ATF3 VGNC VGNC:68503
Canis familiaris ATF3 VGNC VGNC:38209
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