2. Apoptosis
  3. Ferroptosis
  4. Anticancer agent 147

Anticancer agent 147 (compound 6j) 是槐定碱 (HY-N1373) 的衍生物，是一种铁死亡 (Ferroptosis) 诱导剂。Anticancer agent 147 可促进细胞内 Fe2+、活性氧 (ROS) 和 MDA 的积累，并能够增加 ER 应激、上调激活转录因子 ATF3 的表达。Anticancer agent 147 在体外和体内具有良好的抗肝癌作用。

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Anticancer agent 147 Chemical Structure

Anticancer agent 147 Chemical Structure

CAS No. : 2241283-11-2

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Anticancer agent 147 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3.5 μM
Compound: 6j
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30025344]
CNE-2 IC50
4.3 μM
Compound: 6j
Cytotoxicity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30025344]
HepG2 IC50
4.8 μM
Compound: 6j
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30025344]
分子量

578.58

Formula

C32H40BrN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 147 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 1472241283-11-2Anticancer agent147Anticancer agent-147FerroptosisFe2+reactive oxygen speciesROSMDAER stressliver cancerInhibitorinhibitorinhibit

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