FOSB - FosB proto-oncogene, AP-1 transcription factor subunit Gene

中文名称：FosB 原癌基因，AP-1 转录因子亚单位

种属: Homo sapiens

同用名: AP-1; G0S3; GOS3; GOSB

基因 ID: 2354 | 基因类型: protein coding

关于 FOSB

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,467,996-45,475,179 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues and 8 paralogues. Broad expression in gall bladder (RPKM 202.0), bone marrow (RPKM 136.2) and 23 other tissues.

功能概要

Fos 基因家族由 4 个成员组成：FOS、FOSB、FOSL1 和 FOSL2。这些基因编码的亮氨酸拉链蛋白可以与 JUN 家族的蛋白二聚化，从而形成转录因子复合物 AP-1。因此，FOS 蛋白被认为是细胞增殖、分化和转化的调节剂。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

FOSB 基因产物(3)

mRNA	Protein	Name
NM_001114171.2	NP_001107643.1	protein FosB isoform 2
NM_001411069.1	NP_001397998.1	protein FosB isoform 3
NM_006732.3	NP_006723.2	protein FosB isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	22387553	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOSB 蛋白结构

bZIP_1

0
100
200
300
338 a.a.

蛋白主名

其他名称

protein FosB

FBJ murine osteosarcoma viral oncogene homolog B

FOSB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	FOSB	P53539	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	FOSB	P53539	CYTH4	Homo sapiens	Q9UIA0	Validated Y2H	32296183
Intra	FOSB	P53539	ATF2	Homo sapiens	P15336	Anti Tag CoIP	33961781
Intra	FOSB	P53539	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	FOSB	P53539	NEDD9	Homo sapiens	Q14511-2	Validated Y2H	32296183
Intra	FOSB	P53539	VEZF1	Homo sapiens	Q14119	Validated Y2H	32296183
Intra	FOSB	P53539	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	FOSB	P53539	FAM222B	Homo sapiens	Q8WU58	Validated Y2H	32296183
Intra	FOSB	P53539	ROR2	Homo sapiens	Q01974	Validated Y2H	32296183
Intra	FOSB	P53539	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	FOSB	P53539	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	FOSB	P53539	ZC3H10	Homo sapiens	Q96K80	Validated Y2H	32296183
Intra	FOSB	P53539	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	FOSB	P53539	CENPO	Homo sapiens	Q9BU64	Validated Y2H	32296183
Intra	FOSB	P53539	JUNB	Homo sapiens	P17275	Anti Tag CoIP	33961781
Intra	FOSB	P53539	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183
Intra	FOSB	P53539	FOXP3	Homo sapiens	Q9BZS1	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Osteoblastoma

Histiocytoid Hemangioma

Angiolymphoid Hyperplasia With Eosinophilia	Epithelioid Haemangioma
Epithelioid Hemangioma

Proliferative Fasciitis

Hemangioendothelioma

Malignant Epithelioid Hemangioendothelioma

Epithelioid Hemangioendothelioma, Malignant

Spindle Cell Hemangioma

Sch	Spindle Cell Hemangioendothelioma

Endosteal Hyperostosis, Autosomal Dominant

Osteosclerosis	Worth Syndrome
Osteosclerosis, Autosomal Dominant	Hyperostosis, Endosteal
Endosteal Hyperostosis, Worth Type	Worth Disease
Autosomal Dominant Endosteal Hyperostosis	Autosomal Dominant Osteosclerosis, Worth Type
Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus	Autosomal Dominant Osteosclerosis
Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus	Worth'S Syndrome
Worth Type Autosomal Dominant Osteosclerosis	Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus
Osteosclerosis, Autosomal Dominant, Worth Type	WENHY
Endosteal Hyperostosis Autosomal Dominant	Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus
Osteosclerosis Autosomal Dominant	Acquired Osteosclerosis

Subdural Empyema

Empyema, Subdural

Subdural Abscess

Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage	Familial Berry Aneurysm
Familial Intracranial Saccular Aneurysm	Saccular Cerebral Aneurysm
Aneurysm, Intracranial Berry	Aneurysmal Subarachnoid Hemorrhage
Aneurysm, Intracranial Berry, 1

Hobnail Hemangioma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N12361	Osmanthuside B	Inhibitor	98.40%	否
HY-RS05033	FOSB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	FOSB	VGNC	VGNC:62330
Canis familiaris	FOSB	VGNC	VGNC:40941
Bos taurus	FOSB	VGNC	VGNC:29074
Mus musculus	FOSB	MGD	MGI:95575
Rattus norvegicus	FOSB	RGD	RGD:1308198

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