2. Gene
  3. CENPO - centromere protein O Gene

CENPO - centromere protein O Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：着丝粒蛋白 O

种属: Homo sapiens

同用名: CENP-O; MCM21R; ICEN-36

基因 ID: 79172 | 基因类型: protein coding

关于 CENPO

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,793,425-24,822,376 (from NCBI)

This gene has 9 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in placenta (RPKM 11.4), testis (RPKM 8.5) and 24 other tissues.

功能概要

该基因编码间期着丝粒复合体的一个组成部分。编码的蛋白质在整个细胞周期定位于着丝粒，并且是有丝分裂期间双极纺锤体组装、染色体分离和检查点信号传导所必需的。已经观察到该基因编码多种蛋白质同种型的可变剪接转录物变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

CENPO 基因产物(3)

mRNA Protein Name
NM_001199803.3 NP_001186732.1 centromere protein O isoform 2
NM_001322101.2 NP_001309030.1 centromere protein O isoform 1
NM_024322.4 NP_077298.1 centromere protein O isoform 1

CENPO 蛋白结构

CENP-O

CENP-O: Cenp-O kinetochore centromere component (121 - 197)

  • 0
  • 100
  • 200
  • 300 a.a.
蛋白主名 其他名称

centromere protein O

centromeric protein O

CENPO 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CENPO Q9BU64 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
Intra CENPO Q9BU64 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
25416956
Intra CENPO Q9BU64 FOS Homo sapiens Q6FG41
Y2H Prey Pooling
25416956
Intra CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Y2H Array
25416956
Intra CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Y2H Array
32296183
Intra CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Y2H Prey Pooling
25416956
Intra CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Validated Y2H
25416956
Intra CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Y2H Prey Pooling
32296183
Intra CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Anti Tag CoIP
26496610
Intra CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Anti Tag CoIP
33961781
Intra CENPO Q9BU64 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra CENPO Q9BU64 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra CENPO Q9BU64 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra CENPO Q9BU64 FOSB Homo sapiens P53539
Y2H Array
32296183
Intra CENPO Q9BU64 FOSB Homo sapiens P53539
Y2H Prey Pooling
32296183
Intra CENPO Q9BU64 CEP170P1 Homo sapiens Q96L14
Validated Y2H
25416956
Intra CENPO Q9BU64 CEP170P1 Homo sapiens Q96L14
Y2H Prey Pooling
25416956
Intra CENPO Q9BU64 CEP170P1 Homo sapiens Q96L14
Y2H Pooling
16189514
Intra CENPO Q9BU64 CEP170P1 Homo sapiens Q96L14
Y2H Pooling
19447967
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Body Mass Index Quantitative Trait Locus 19

Obesity

BMIQ19

Obesity, Susceptibility To

Obesity, Susceptibility To, Bmiq19

Obesity Bmiq19

{Obesity, Susceptibility To, Bmiq19}
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
3-Methylglutaconic Aciduria With Cataracts, Neurologic Involvement And Neutropenia

3-Methylglutaconic Aciduria Type 7

Mga7

3-Methylglutaconic Aciduria Type Vii

Megcann

Mgca7

3-Methylglutaconic Aciduria-Cataract-Neurologic Involvement-Neutropenia Syndrome

3-Methylglutaconic Aciduria With Cataracts, Neurologic Involvement, And Neutropenia
3-Methylglutaconic Aciduria, Type Iv

3-Methylglutaconic Aciduria Type 4

Mga4

MGCA4

3-Methylglutaconic Aciduria Type Iv

Mga, Type Iv

Mga Type Iv

Not Otherwise Specified 3-Mga-Uria Type

3 Alpha Methylglutaconic Aciduria Type Iv

3 Methylglutaconic Aciduria Type Iv
Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1

Diabetes Mellitus, Insulin-Dependent, 2

IDDM2

Insulin-Dependent Diabetes Mellitus 2

NIDDM1

Diabetes Mellitus, Noninsulin-Dependent 1

T1D2

Type 2 Diabetes Mellitus 1

T2D1

Noninsulin-Dependent Diabetes Mellitus 1

Diabetes Mellitus, Non-Insulin-Dependent, 1

Type 2 Diabetes Mellitus 1, Susceptibility To

Diabetes Mellitus, Insulin-Dependent, Type 2

Diabetes Mellitus, Non-Insulin-Dependent
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02487 CENPO Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CENPO RGD RGD:1590328
Felis catus CENPO VGNC VGNC:60759
Mus musculus CENPO MGD MGI:1923800
Canis familiaris CENPO VGNC VGNC:39110
Bos taurus CENPO VGNC VGNC:27183
Macaca mulatta CENPO VGNC VGNC:71118
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