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  2. CENPP - centromere protein P Gene

CENPP - centromere protein P Gene

中文名称:着丝粒蛋白 P

种属: Homo sapiens

同用名: CENP-P

基因 ID: 401541 | 基因类型: protein coding

关于 CENPP

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:92,325,468-92,620,529 (from NCBI)

This gene has 4 transcripts (splice variants) and 165 orthologues. Ubiquitous expression in skin (RPKM 7.8), esophagus (RPKM 2.2) and 24 other tissues.

功能概要

CENPP 是 CENPH (MIM 605607) -CENPI (MIM 300065) 相关着丝粒复合体的一个亚基,其将 CENPA (MIM 117139) 靶向着丝粒,并且是适当的着丝粒功能和有丝分裂进程所必需的 (Okada 等人,2006 [PubMed 16622420) ]) .[OMIM 提供,2008 年 3 月]

CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

CENPP 基因产物(3)

mRNA Protein Name
NM_001012267.3 NP_001012267.1 centromere protein P isoform a
NM_001286969.1 NP_001273898.1 centromere protein P isoform b
NM_001286971.1 NP_001273900.1 centromere protein P isoform c
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of inner kinetochore IPI
IPI: 通过物理相互作用推断
36085283 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CENPP 蛋白结构

CENP-P

CENP-P: CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P (103 - 279)

  • 0
  • 100
  • 200
  • 288 a.a.
蛋白主名 其他名称

centromere protein P

CENPP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CENPP Q6IPU0 NHLH1 Homo sapiens Q5T203
Validated Y2H
25416956
Intra CENPP Q6IPU0 NHLH1 Homo sapiens Q5T203
Y2H Prey Pooling
25416956
Intra CENPP Q6IPU0 POLR3K Homo sapiens Q9Y2Y1
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 POLR3K Homo sapiens Q9Y2Y1
Validated Y2H
32296183
Intra CENPP Q6IPU0 POLR3K Homo sapiens Q9Y2Y1
Y2H Array
32296183
Intra CENPP Q6IPU0 TOX2 Homo sapiens Q96NM4-3
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 TOX2 Homo sapiens Q96NM4-3
Validated Y2H
32296183
Intra CENPP Q6IPU0 TOX2 Homo sapiens Q96NM4-3
Y2H Array
32296183
Intra CENPP Q6IPU0 ZNF765 Homo sapiens Q7L2R6-2
Validated Y2H
32296183
Intra CENPP Q6IPU0 BACH2 Homo sapiens Q9BYV9
Validated Y2H
32296183
Intra CENPP Q6IPU0 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra CENPP Q6IPU0 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 KLC3 Homo sapiens Q6P597
Y2H Array
25416956
Intra CENPP Q6IPU0 KLC3 Homo sapiens Q6P597
Y2H Prey Pooling
25416956
Intra CENPP Q6IPU0 KLC3 Homo sapiens Q6P597
Validated Y2H
25416956
Intra CENPP Q6IPU0 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 HAUS1 Homo sapiens Q96CS2
Validated Y2H
32296183
Intra CENPP Q6IPU0 HAUS1 Homo sapiens Q96CS2
Y2H Array
32296183
Intra CENPP Q6IPU0 PKNOX2 Homo sapiens Q96KN3
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 PKNOX2 Homo sapiens Q96KN3
Validated Y2H
32296183
Intra CENPP Q6IPU0 PKNOX2 Homo sapiens Q96KN3
Y2H Array
32296183
Intra CENPP Q6IPU0 KIAA1328 Homo sapiens Q86T90
Validated Y2H
32296183
Intra CENPP Q6IPU0 KIAA1328 Homo sapiens Q86T90
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 KIAA1328 Homo sapiens Q86T90
Y2H Array
32296183
Intra CENPP Q6IPU0 ATP6V0D2 Homo sapiens Q8N8Y2
Validated Y2H
32296183
Intra CENPP Q6IPU0 NHLH1 Homo sapiens Q02575
Y2H Array
32296183
Intra CENPP Q6IPU0 NHLH1 Homo sapiens Q02575
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra CENPP Q6IPU0 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra CENPP Q6IPU0 CCDC85B Homo sapiens Q15834
Y2H Array
32296183
Intra CENPP Q6IPU0 CCDC85B Homo sapiens Q15834
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra CENPP Q6IPU0 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
Intra CENPP Q6IPU0 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Intra CENPP Q6IPU0 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Intra CENPP Q6IPU0 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra CENPP Q6IPU0 TEX11 Homo sapiens Q8IYF3
Y2H Prey Pooling
25416956
Intra CENPP Q6IPU0 TEX11 Homo sapiens Q8IYF3
Validated Y2H
25416956
Intra CENPP Q6IPU0 TEX11 Homo sapiens Q8IYF3
Y2H Array
25416956
Intra CENPP Q6IPU0 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 CEP44 Homo sapiens Q9C0F1
Y2H Array
32296183
Intra CENPP Q6IPU0 CEP44 Homo sapiens Q9C0F1
Validated Y2H
32296183
Intra CENPP Q6IPU0 C2orf88 Homo sapiens Q9BSF0
Validated Y2H
32296183
Intra CENPP Q6IPU0 C2orf88 Homo sapiens Q9BSF0
Y2H Array
32296183
Intra CENPP Q6IPU0 C2orf88 Homo sapiens Q9BSF0
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 RPIA Homo sapiens P49247
Y2H Array
25416956
Intra CENPP Q6IPU0 RPIA Homo sapiens P49247
Validated Y2H
25416956
Intra CENPP Q6IPU0 CENPO Homo sapiens Q9BU64
Anti Tag CoIP
33961781
Intra CENPP Q6IPU0 CENPO Homo sapiens Q9BU64
Anti Tag CoIP
28514442
Intra CENPP Q6IPU0 CENPO Homo sapiens Q9BU64
Validated Y2H
32296183
Intra CENPP Q6IPU0 CENPO Homo sapiens Q9BU64
Y2H Array
32296183
Intra CENPP Q6IPU0 CENPO Homo sapiens Q9BU64
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 SERTAD3 Homo sapiens Q9UJW9
Validated Y2H
32296183
Intra CENPP Q6IPU0 SERTAD3 Homo sapiens Q9UJW9
Y2H Array
32296183
Intra CENPP Q6IPU0 SERTAD3 Homo sapiens Q9UJW9
Y2H Prey Pooling
32296183
Intra CENPP Q6IPU0 ZNF341 Homo sapiens Q9BYN7
Y2H Prey Pooling
25416956
Intra CENPP Q6IPU0 ZNF341 Homo sapiens Q9BYN7
Validated Y2H
25416956
Intra CENPP Q6IPU0 ZNF341 Homo sapiens Q9BYN7
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intervertebral Disc Disease

Lumbar Disc Disease

Intervertebral Disc Disorder

IDD

Lumbar Disc Herniation

Lumbar Disc Degeneration

Intervertebral Disc Disease, Susceptibility To

Lumbar Disc Herniation, Susceptibility To

Lumbar Disc Disease, Susceptibility To

Intervertebral Disc Degeneration

Discogenic Disease

Discogenic Disorder

Disorder Of Intervertebral Disc

Intervertebral Disk Degeneration

Intervertebral Disk Disease

Ldd

Ldh

Lumbar Disc Degeneration, Susceptibility To

Degeneration Of Lumbar Intervertebral Disc

Intervertebral Disk Displacement

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CENPP VGNC VGNC:102912
Rattus norvegicus CENPP RGD RGD:1589530
Canis familiaris CENPP VGNC VGNC:39111
Bos taurus CENPP VGNC VGNC:59195
Mus musculus CENPP MGD MGI:1913586
Macaca mulatta CENPP VGNC VGNC:97750