ZNF341 - zinc finger protein 341 Gene

中文名称：锌指蛋白 341

种属: Homo sapiens

同用名: HIES3

基因 ID: 84905 | 基因类型: protein coding

关于 ZNF341

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:33,731,996-33,792,269 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 1.6), spleen (RPKM 1.5) and 25 other tissues.

功能概要

启用 DNA 结合活性和 DNA 结合转录激活因子活性。预计参与转录调控，以 DNA 为模板。位于核内。涉及高 IgE 复发性感染综合征 3。[由基因组资源联盟提供，2022 年 4 月]

Enables DNA binding activity and DNA-binding transcription activator activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleus. Implicated in hyper IgE recurrent Infection syndrome 3. [provided by Alliance of Genome Resources, Apr 2022]

ZNF341 基因产物(3)

mRNA	Protein	Name
NM_001282933.2	NP_001269862.1	zinc finger protein 341 isoform 1
NM_001282935.2	NP_001269864.1	zinc finger protein 341 isoform 3
NM_032819.5	NP_116208.3	zinc finger protein 341 isoform 2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	29907690	GOA
enables DNA-binding transcription activator activity	IDA IDA: 通过直接分析推断	29907690	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	29907690	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZNF341 蛋白结构

zf-C2H2_6

zf-H2C2_2

zf-C2H2_4

zf-C2H2_6

zf-C2H2

zf-C2H2_4

zf-H2C2_2

0
200
400
600
800
854 a.a.

蛋白主名

其他名称

zinc finger protein 341

ZNF341 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ZNF341	Q9BYN7	C11orf68	Homo sapiens	Q9H3H3-3	Validated Y2H	32296183
Intra	ZNF341	Q9BYN7	KLHL38	Homo sapiens	Q2WGJ6	Y2H Array	25416956
Intra	ZNF341	Q9BYN7	CSTF2	Homo sapiens	P33240	Y2H Array	25416956
Intra	ZNF341	Q9BYN7	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
Intra	ZNF341	Q9BYN7	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hyper-Ige Recurrent Infection Syndrome 3, Autosomal Recessive

HIES3

Hyper Ige Recurrent Infection Syndrome 3

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Immunodeficiency 63 With Lymphoproliferation And Autoimmunity

IMD63	Il2rb Deficiency
Cd122 Deficiency	Immunodeficiency 63
Interleukin 2 Receptor, Beta, Deficiency Of	Deficiency Of Interleukin 2 Receptor Beta

Hyper Ige Recurrent Infection Syndrome 1

Job Syndrome	Hyper-Ige Recurrent Infection Syndrome 1
Hyperimmunoglobulin E Syndrome	Job'S Syndrome
Recurring Cold Staphylococcal Abscesses	Ige Syndromes
Buckley Syndrome	Hie - [Hyperimmunoglobulin E] Syndrome
Job-Buckley Syndrome	Quie-Hill Syndrome

Immunodeficiency 35

Tyrosine Kinase 2 Deficiency	IMD35
Tyk2 Deficiency	Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis
Susceptibility To Infection Due To Tyk2 Deficiency	Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive
Hies With Atypical Mycobacteriosis, Autosomal Recessive	Autosomal Recessiv Hies With Atypical Mycobacteriosis
Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency	Autosomal Recessive Hies With Atypical Mycobacteriosis

Immunodeficiency 11

Immunodeficiency 11a	Severe Combined Immunodeficiency Due To Card11 Deficiency
IMD11A	Imd11
Card11 Immunodeficiency	Scid Due To Card11 Deficiency
Card11 Deficiency	Immunodeficiency 11 A

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

T Cell And Nk Cell Immunodeficiency

Hepatic Venoocclusive Disease With Immunodeficiency

VODI	Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Hepatic Veno-Occlusive Disease With Immunodeficiency	Familial Veno-Occlusive Disease With Immunodeficiency
Veno-Occlusive Disease And Immunodeficiency Syndrome	Vodi Syndrome
Vodi - [Veno-Occlusive Disease Immunodeficiency] Syndrome

Phaeohyphomycosis

Infection By Dematiacious Fungi	Phaehyphomycosis
Phaeomycosis	Pheohyphomycosis
Infection By Dematiacious Fungi [Phaehyphomycosis]	Dematiaceous Fungal Infection

Hyper Ige Syndrome

Hyper-Ige Syndrome	Hyper Immunoglobulin E Syndrome
Hies	Hyper-Ige Recurrent Infection Syndrome
Hyperimmunoglobulin E Syndrome	Hyper Ige
Job Syndrome	Hartnup Disease

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16128	ZNF341 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	ZNF341	VGNC	VGNC:37253
Mus musculus	ZNF341	MGD	MGI:2682937
Macaca mulatta	ZNF341	VGNC	VGNC:79001
Felis catus	ZNF341	VGNC	VGNC:67292
Rattus norvegicus	ZNF341	RGD	RGD:1564726
Canis familiaris	ZNF341	VGNC	VGNC:48705

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