2. Gene
  3. CSTF2 - cleavage stimulation factor subunit 2 Gene

CSTF2 - cleavage stimulation factor subunit 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：裂解刺激因子亚基 2

种属: Homo sapiens

同用名: CstF-64

基因 ID: 1478 | 基因类型: protein coding

关于 CSTF2

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:100,820,391-100,841,520 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 6.8), testis (RPKM 6.5) and 24 other tissues.

功能概要

该基因编码具有 RRM (RNA 识别基序) 结构域的核蛋白。该蛋白质是参与 pre-mRNA 的 3' 末端切割和聚腺苷酸化的切割刺激因子 (CSTF) 复合物的成员。具体来说，这种蛋白质结合 mRNA 的 3'-非翻译区内富含 GU 的元素。[RefSeq 提供，2008 年 7 月]

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]

CSTF2 基因产物(3)

mRNA Protein Name
NM_001306206.2 NP_001293135.1 cleavage stimulation factor subunit 2 isoform 1
NM_001306209.2 NP_001293138.1 cleavage stimulation factor subunit 2 isoform 3
NM_001325.3 NP_001316.1 cleavage stimulation factor subunit 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
1741396 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10477523 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA 3'-end processing IMP
IMP: 通过突变表型推断
32816001 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cleavage body IDA
IDA: 通过直接分析推断
11598190 GOA
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: 通过直接分析推断
18305108 GOA
located in nucleus IMP
IMP: 通过突变表型推断
32816001 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CSTF2 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (18 - 88)

CSTF2_hinge

CSTF2_hinge: Hinge domain of cleavage stimulation factor subunit 2 (111 - 192)

CSTF_C

CSTF_C: Transcription termination and cleavage factor C-terminal (531 - 574)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 577 a.a.
蛋白主名 其他名称

cleavage stimulation factor subunit 2

CF-1 64 kDa subunit

CSTF2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CSTF2 P33240 CTBP2 Homo sapiens P56545-3
Validated Y2H
32296183
Intra CSTF2 P33240 CTBP2 Homo sapiens P56545-3
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 CTBP2 Homo sapiens P56545-3
Y2H Array
32296183
Intra CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra CSTF2 P33240 METTL15 Homo sapiens A6NJ78-4
Y2H Array
32296183
Intra CSTF2 P33240 METTL15 Homo sapiens A6NJ78-4
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 CPSF2 Homo sapiens Q9P2I0
Anti Tag CoIP
18688255
Intra CSTF2 P33240 PRDM6 Homo sapiens Q9NQX0
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 PRDM6 Homo sapiens Q9NQX0
Validated Y2H
32296183
Intra CSTF2 P33240 PRDM6 Homo sapiens Q9NQX0
Y2H Array
32296183
Intra CSTF2 P33240 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra CSTF2 P33240 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra CSTF2 P33240 SPAG8 Homo sapiens Q99932-2
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra CSTF2 P33240 SPAG8 Homo sapiens Q99932-2
Y2H Array
32296183
Intra CSTF2 P33240 USP54 Homo sapiens Q70EL1-9
Validated Y2H
32296183
Intra CSTF2 P33240 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra CSTF2 P33240 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
Intra CSTF2 P33240 SAXO4 Homo sapiens Q7Z5V6-2
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 SAXO4 Homo sapiens Q7Z5V6-2
Y2H Array
32296183
Intra CSTF2 P33240 TLE3 Homo sapiens Q04726-4
Y2H Array
32296183
Intra CSTF2 P33240 TLE3 Homo sapiens Q04726-4
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 TLE3 Homo sapiens Q04726-4
Validated Y2H
32296183
Intra CSTF2 P33240 POU6F2 Homo sapiens P78424
Validated Y2H
32296183
Intra CSTF2 P33240 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra CSTF2 P33240 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 UFSP1 Homo sapiens Q6NVU6
Y2H Array
32296183
Intra CSTF2 P33240 UFSP1 Homo sapiens Q6NVU6
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 UFSP1 Homo sapiens Q6NVU6
Validated Y2H
32296183
Intra CSTF2 P33240 ANKRD10 Homo sapiens Q9NXR5-2
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 ANKRD10 Homo sapiens Q9NXR5-2
Validated Y2H
32296183
Intra CSTF2 P33240 ANKRD10 Homo sapiens Q9NXR5-2
Y2H Array
32296183
Intra CSTF2 P33240 FAM168B Homo sapiens A1KXE4-2
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 FAM168B Homo sapiens A1KXE4-2
Y2H Array
32296183
Intra CSTF2 P33240 ABHD11 Homo sapiens Q8NFV4-4
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 ABHD11 Homo sapiens Q8NFV4-4
Y2H Array
32296183
Intra CSTF2 P33240 ABHD11 Homo sapiens Q8NFV4-4
Validated Y2H
32296183
Intra CSTF2 P33240 TSC1 Homo sapiens Q86WV8
Validated Y2H
32296183
Intra CSTF2 P33240 TSC1 Homo sapiens Q86WV8
Y2H Array
32296183
Intra CSTF2 P33240 TSC1 Homo sapiens Q86WV8
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 ATP23 Homo sapiens Q9Y6H3
Validated Y2H
32296183
Intra CSTF2 P33240 ATP23 Homo sapiens Q9Y6H3
Y2H Array
32296183
Intra CSTF2 P33240 ATP23 Homo sapiens Q9Y6H3
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 STH Homo sapiens Q8IWL8
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 STH Homo sapiens Q8IWL8
Validated Y2H
32296183
Intra CSTF2 P33240 STH Homo sapiens Q8IWL8
Y2H Array
32296183
Intra CSTF2 P33240 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra CSTF2 P33240 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 TFG Homo sapiens Q92734
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 TFG Homo sapiens Q92734
Validated Y2H
25416956
Intra CSTF2 P33240 TFG Homo sapiens Q92734
Validated Y2H
32296183
Intra CSTF2 P33240 TFG Homo sapiens Q92734
Y2H Array
32296183
Intra CSTF2 P33240 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra CSTF2 P33240 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra CSTF2 P33240 PARN Homo sapiens O95453
Anti Bait CoIP
20379136
Intra CSTF2 P33240 CEACAM6 Homo sapiens P40199
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 CEACAM6 Homo sapiens P40199
Validated Y2H
32296183
Intra CSTF2 P33240 CEACAM6 Homo sapiens P40199
Y2H Array
32296183
Intra CSTF2 P33240 BARD1 Homo sapiens Q99728
Anti Bait CoIP
20379136
Intra CSTF2 P33240 BARD1 Homo sapiens Q99728
Anti Bait CoIP
10477523
Intra CSTF2 P33240 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra CSTF2 P33240 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra CSTF2 P33240 HGS Homo sapiens O14964
Y2H Array
25416956
Intra CSTF2 P33240 HGS Homo sapiens O14964
Y2H Array
32296183
Intra CSTF2 P33240 HGS Homo sapiens O14964
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
16189514
Intra CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
25416956
Intra CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra CSTF2 P33240 CNOT2 Homo sapiens Q9NZN8
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 CNOT2 Homo sapiens Q9NZN8
Validated Y2H
32296183
Intra CSTF2 P33240 CNOT2 Homo sapiens Q9NZN8
Y2H Array
32296183
Intra CSTF2 P33240 HDHD3 Homo sapiens Q9BSH5
Validated Y2H
32296183
Intra CSTF2 P33240 HDHD3 Homo sapiens Q9BSH5
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 HDHD3 Homo sapiens Q9BSH5
Y2H Array
32296183
Intra CSTF2 P33240 RFX6 Homo sapiens Q8HWS3
Validated Y2H
32296183
Intra CSTF2 P33240 RFX6 Homo sapiens Q8HWS3
Y2H Array
32296183
Intra CSTF2 P33240 RFX6 Homo sapiens Q8HWS3
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 METTL27 Homo sapiens Q8N6F8
Y2H Array
32296183
Intra CSTF2 P33240 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32296183
Intra CSTF2 P33240 METTL27 Homo sapiens Q8N6F8
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 ZNF341 Homo sapiens Q9BYN7
Validated Y2H
25416956
Intra CSTF2 P33240 ZNF341 Homo sapiens Q9BYN7
Y2H Prey Pooling
25416956
Intra CSTF2 P33240 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra CSTF2 P33240 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra CSTF2 P33240 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra CSTF2 P33240 SPAG8 Homo sapiens Q99932
Y2H Prey Pooling
25416956
Intra CSTF2 P33240 SPAG8 Homo sapiens Q99932
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03274 CSTF2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03275 CSTF2T Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CSTF2 VGNC VGNC:39683
Macaca mulatta CSTF2 VGNC VGNC:71536
Mus musculus CSTF2 MGD MGI:1343054
Rattus norvegicus CSTF2 RGD RGD:1596566
Bos taurus CSTF2 VGNC VGNC:27781
Felis catus CSTF2 VGNC VGNC:61240
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z