2. Gene
  3. JDP2 - Jun dimerization protein 2 Gene

JDP2 - Jun dimerization protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Jun 二聚化蛋白 2

种属: Homo sapiens

同用名: JUNDM2

基因 ID: 122953 | 基因类型: protein coding

关于 JDP2

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:75,426,943-75,474,107 (from NCBI)

This gene has 8 transcripts (splice variants), 282 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 5.0), bone marrow (RPKM 4.2) and 25 other tissues.

功能概要

启用 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性和序列特异性双链 DNA 结合活性。参与 RNA 聚合酶 II 对转录的负调控。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

JDP2 基因产物(4)

mRNA Protein Name
NM_001135047.2 NP_001128519.1 jun dimerization protein 2 isoform a
NM_001135048.2 NP_001128520.1 jun dimerization protein 2 isoform a
NM_001135049.1 NP_001128521.1 jun dimerization protein 2 isoform b
NM_130469.3 NP_569736.1 jun dimerization protein 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
18671972 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18671972 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II EXP
EXP: 通过实验结果推断
11231009 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18671972 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex EXP
EXP: 通过实验结果推断
11231009 GOA
located in nucleus EXP
EXP: 通过实验结果推断
11231009 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

JDP2 蛋白结构

bZIP_1

bZIP_1: bZIP transcription factor (70 - 128)

  • 0
  • 100
  • 163 a.a.
蛋白主名 其他名称

jun dimerization protein 2

progesterone receptor co-activator

JDP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra JDP2 Q8WYK2 CREB5 Homo sapiens Q02930-3
Y2H Array
32296183
Intra JDP2 Q8WYK2 CREB5 Homo sapiens Q02930-3
Y2H Prey Pooling
32296183
Intra JDP2 Q8WYK2 ATF4 Homo sapiens P18848
Y2H Array
32296183
Intra JDP2 Q8WYK2 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
Intra JDP2 Q8WYK2 IRF2BP1 Homo sapiens Q8IU81
Pull Down
18671972
Intra JDP2 Q8WYK2 IRF2BP1 Homo sapiens Q8IU81
Anti Tag CoIP
18671972
Intra JDP2 Q8WYK2 IRF2BP1 Homo sapiens Q8IU81
Anti Bait CoIP
18671972
Intra JDP2 Q8WYK2 DDIT3 Homo sapiens P35638
Y2H Array
32296183
Intra JDP2 Q8WYK2 DDIT3 Homo sapiens P35638
Y2H Prey Pooling
32296183
Intra JDP2 Q8WYK2 JUNB Homo sapiens P17275
Anti Tag CoIP
18671972
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis

Acanthamoeba Encephalitis

Acanthamoeba Granulomatous Encephalitis

Granulomatous Amebic Encephalitis Due To Acanthamoeba
Primary Amebic Meningoencephalitis

Pam

Naegleria Fowleri Infection

Meningoencephalitis Caused By Naegleria Fowleri

Primary Amoebic Meningoencephalitis
Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy

Autosomal Dominant Adult-Onset Proximal Sma

Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type

Finkel Disease

Smafk

Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant

Autosomal Dominant Adult Proximal Spinal Muscular Atrophy

Finkel Late-Adult Type Sma
Keratitis, Hereditary

Keratitis

Autosomal Dominant Keratitis

Hereditary Keratitis

Dominantly Inherited Keratitis

Keratitis Hereditary

KERH
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07034 JDP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris JDP2 VGNC VGNC:42185
Felis catus JDP2 VGNC VGNC:63004
Bos taurus JDP2 VGNC VGNC:30374
Mus musculus JDP2 MGD MGI:1932093
Macaca mulatta JDP2 VGNC VGNC:73845
Rattus norvegicus JDP2 RGD RGD:621611
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