1. Gene
  2. BARHL2 - BarH like homeobox 2 Gene

BARHL2 - BarH like homeobox 2 Gene

中文名称:BarH 样同源盒 2

种属: Homo sapiens

基因 ID: 343472 | 基因类型: protein coding

关于 BARHL2

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:90,711,539-90,717,302 (from NCBI)

This gene has 1 transcript (splice variant), 205 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 1.8).

功能概要

启用序列特异性双链 DNA 结合活性。预计参与 RNA 聚合酶 II 的转录调控。预计在几个过程的上游或内部起作用,包括神经元的产生;大分子生物合成过程的正调控;和轴突延伸的调节。预测是染色质的一部分。预计活跃于核心。与口腔鳞状细胞癌有关。结直肠癌生物标志物;口腔鳞状细胞癌;和胃癌。 [由基因组资源联盟提供,2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including generation of neurons; positive regulation of macromolecule biosynthetic process; and regulation of axon extension. Predicted to be part of chromatin. Predicted to be active in nucleus. Implicated in oral squamous cell carcinoma. Biomarker of colorectal cancer; oral squamous cell carcinoma; and stomach Cancer. [provided by Alliance of Genome Resources, Apr 2022]

BARHL2 基因产物(1)

mRNA Protein Name
NM_020063.2 NP_064447.1 barH-like 2 homeobox protein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BARHL2 蛋白结构

Homeobox

Homeobox: Homeobox domain (233 - 289)

  • 0
  • 100
  • 200
  • 300
  • 387 a.a.
蛋白主名 其他名称

barH-like 2 homeobox protein

BARHL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BARHL2 Q9NY43 REL Homo sapiens Q04864 25416956
种属内
BARHL2 Q9NY43 PLEKHF2 Homo sapiens Q9H8W4 32296183
种属内
BARHL2 Q9NY43 PLEKHF2 Homo sapiens Q9H8W4 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Xeroderma Pigmentosum Group E

Xeroderma Pigmentosum, Group E

Xeroderma Pigmentosum V

Xp Group E

Xp5

Xpe

Xeroderma Pigmentosum, Complementation Group E

Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris BARHL2 VGNC VGNC:38381
Felis catus BARHL2 VGNC VGNC:69109
Bos taurus BARHL2 VGNC VGNC:26422
Rattus norvegicus BARHL2 RGD RGD:620726
Macaca mulatta BARHL2 VGNC VGNC:70227
Mus musculus BARHL2 MGD MGI:1859314