2. Gene
  3. BRD7 - bromodomain containing 7 Gene

BRD7 - bromodomain containing 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含溴结构域 7

种属: Homo sapiens

同用名: BP75; NAG4; CELTIX1; SMARCI1

基因 ID: 29117 | 基因类型: protein coding

关于 BRD7

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,315,957-50,368,988 (from NCBI)

This gene has 7 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 21.8), spleen (RPKM 16.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是含溴结构域的蛋白质家族的成员。该基因的产物已被鉴定为一种形式的 SWI/SNF 染色质重塑复合物的组成部分，并且是一种与 p53 相互作用的蛋白质，并且是 p53 依赖性致癌基因诱导的衰老所必需的，可防止肿瘤生长。在 2、3、6、13 和 14 号染色体上描述了假基因。可变剪接导致多个转录变体。[RefSeq 提供，2010 年 7 月]

This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

BRD7 基因产物(12)

mRNA Protein Name
NM_013263.5 NP_037395.2 bromodomain-containing protein 7 isoform 2
XM_017023180.2 XP_016878669.1 bromodomain-containing protein 7 isoform X6
NM_001173984.3 NP_001167455.1 bromodomain-containing protein 7 isoform 1
XM_011523046.4 XP_011521348.1 bromodomain-containing protein 7 isoform X1
XM_011523048.3 XP_011521350.1 bromodomain-containing protein 7 isoform X3
XM_047434006.1 XP_047289962.1 bromodomain-containing protein 7 isoform X7
XM_011523047.3 XP_011521349.1 bromodomain-containing protein 7 isoform X2
XM_047434007.1 XP_047289963.1 bromodomain-containing protein 7 isoform X8
XM_011523050.4 XP_011521352.1 bromodomain-containing protein 7 isoform X10
XM_047434008.1 XP_047289964.1 bromodomain-containing protein 7 isoform X9
XM_017023179.2 XP_016878668.1 bromodomain-containing protein 7 isoform X5
XM_011523049.3 XP_011521351.1 bromodomain-containing protein 7 isoform X4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone binding IDA
IDA: 通过直接分析推断
12489984 GOA
enables lysine-acetylated histone binding IDA
IDA: 通过直接分析推断
16265664 GOA
enables p53 binding IPI
IPI: 通过物理相互作用推断
20228809 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12489984 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
20228809 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
20228809 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
16265664 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16265664 GOA
involved in negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
16265664 GOA
involved in regulation of mitotic cell cycle IMP
IMP: 通过突变表型推断
20228809 GOA
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12489984 GOA
involved in transcription initiation-coupled chromatin remodeling IMP
IMP: 通过突变表型推断
20228809 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11025449 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BRD7 蛋白结构

Bromodomain

Bromodomain: Bromodomain (141 - 223)

DUF3512

DUF3512: Domain of unknown function (DUF3512) (287 - 534)

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  • 200
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  • 500
  • 600
  • 651 a.a.
蛋白主名 其他名称

bromodomain-containing protein 7

75 kDa bromodomain protein

protein CELTIX-1

关联疾病

疾病名称 别名
Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium

Adenosquamous Carcinoma Of The Endometrium

Endometrial Adenosquamous Cancer

Endometrial Adenosquamous Cell Carcinoma
Neurilemmomatosis

Schwannomatosis

Neurofibromatosis Type 3

Nf3

Neurilemmomatosis Congenital Cutaneous

Neurinomatosis

Congenital Cutaneous Neurilemmomatosis

Multiple Neurilemmomas

Multiple Schwannomas

Neurilemmomatosis, Congenital Cutaneous

Schwannomatosis 1

Neurofibromatosis 3

Mixed Central And Peripheral Neurofibromatosis

Nf3 - [Neurofibromatosis Type 3]
Granular Cell Carcinoma

Granular Cell Cancer

Granular Cell Adenocarcinoma
Malignant Granular Cell Myoblastoma

Malignant Granular Cell Tumor

Granular Cell Tumor, Malignant

Malignant Granular Cell Neoplasm
Rhabdoid Cancer

Rhabdoid Tumor

Malignant Rhabdoid Tumor

Malignant Rhabdoid Tumour

Rhabdoid Sarcoma

Rhabdoid Tumor Predisposition Syndrome 1

Rhabdoid Tumor Predisposition Syndrome 2

Atypical Teratoid Rhabdoid Tumor

Brain Tumor, Posterior Fossa, Of Infancy, Familial

Atypical Teratoid/Rhabdoid Tumor
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114322 VZ185 Inhibitor 98.00% 否
HY-100352 BI-9564 Inhibitor 98.73% 否
HY-110374 NVS-CECR2-1 Inhibitor 99.40% 否
HY-100517 TP-472 Inhibitor 99.52% 否
HY-101121 NI-42 Inhibitor 99.53% 否
HY-116227 (2S,3R)-LP99 Inhibitor / 否
HY-149806 Bromodomain IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus BRD7 RGD RGD:1309891
Felis catus BRD7 VGNC VGNC:60169
Bos taurus BRD7 VGNC VGNC:26560
Mus musculus BRD7 MGD MGI:1349766
Canis familiaris BRD7 VGNC VGNC:38521
Macaca mulatta BRD7 VGNC VGNC:103794
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