NDUFA5 - NADH:ubiquinone oxidoreductase subunit A5 Gene

中文名称：NADH：泛醌氧化还原酶亚基 A5

种属: Homo sapiens

同用名: B13; NUFM; UQOR13; CI-13kB; CI-13KD-B

基因 ID: 4698 | 基因类型: protein coding

关于 NDUFA5

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:123,536,997-123,601,651 (from NCBI)

This gene has 25 transcripts (splice variants) and 258 orthologues. Ubiquitous expression in thyroid (RPKM 21.8), heart (RPKM 20.7) and 25 other tissues.

功能概要

该核基因编码一种保守蛋白，该蛋白包含线粒体呼吸链复合体 I 的 B13 亚基。编码的蛋白质定位于线粒体内膜，据认为它有助于将电子从 NADH 转移到泛醌。可变剪接导致多个转录本变体。该基因在 1、3、6、8、9、11、12 和 16 号染色体上有许多假基因。[RefSeq 提供，2014 年 4 月]

This nuclear gene encodes a conserved protein that comprises the B13 subunit of complex I of the mitochondrial respiratory chain. The encoded protein localizes to the inner mitochondrial membrane, where it is thought to aid in the transfer of electrons from NADH to ubiquinone. Alternative splicing results in multiple transcript variants. There are numerous pseudogenes of this gene on chromosomes 1, 3, 6, 8, 9, 11, 12, and 16. [provided by RefSeq, Apr 2014]

NDUFA5 基因产物(6)

mRNA	Protein	Name
NM_001282419.3	NP_001269348.1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 2
NM_001282420.3	NP_001269349.1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 3
NM_001282421.3	NP_001269350.1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 4
NM_001282422.3	NP_001269351.1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 5
NM_001291304.2	NP_001278233.1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 6
NM_005000.5	NP_004991.1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	24344204	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mitochondrial respiratory chain complex I assembly	IMP IMP: 通过突变表型推断	27626371	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrial inner membrane	IDA IDA: 通过直接分析推断	28844695	GOA
part of respiratory chain complex I	IDA IDA: 通过直接分析推断	12611891	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NDUFA5 蛋白结构

ETC_C1_NDUFA5

0
100
116 a.a.

蛋白主名

其他名称

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa

NDUFA5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NDUFA5	Q16718	NDUFS3	Homo sapiens	O75489	Y2H Array	32296183
Intra	NDUFA5	Q16718	NDUFS3	Homo sapiens	O75489	Y2H Prey Pooling	32296183
Intra	NDUFA5	Q16718	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	NDUFA5	Q16718	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	NDUFA5	Q16718	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	NDUFA5	Q16718	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	NDUFA5	Q16718	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	NDUFA5	Q16718	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	NDUFA5	Q16718	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	NDUFA5	Q16718	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	NDUFA5	Q16718	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	NDUFA5	Q16718	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Endobronchial Leiomyoma

Korean Hemorrhagic Fever

Hemorrhagic Fever With Renal Syndrome

Lung Leiomyoma

Pulmonary Leiomyoma

Leiomyoma Of Lung

Oral Tuberculosis

Tuberculosis, Oral

Medullary Colon Carcinoma

Polyomavirus-Associated Nephropathy

Polyomavirus Associated Nephropathy

Pvan

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Leber Hereditary Optic Neuropathy, Modifier Of

Leber Optic Atrophy	Leber Hereditary Optic Neuropathy
LHON	Leber'S Hereditary Optic Neuropathy
Leber Optic Atrophy, Susceptibility To	Leber'S Optic Atrophy
LOAM	Loas
Leber'S Disease	Leber'S Optic Neuropathy
Optic Atrophy, Hereditary, Leber	Lhon, Modifier Of
Optic Atrophy, Leber Type	Hereditary Optic Neuroretinopathy
Leber Hereditary Optic Atrophy	Loa
Optic Atrophy Leber Type	Leber Hereditary Optic Neuropathy, Modifier
Leber Hereditary Optic Neuropathy Susceptibility	Modifier Of Leber Hereditary Optic Neuropathy
Lebers Hereditary Optic Neuropathy	Leber Congenital Amaurosis

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-169281	Antiviral agent 61		/	否
HY-RS09131	NDUFA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	NDUFA5	VGNC	VGNC:31949
Macaca mulatta	NDUFA5	VGNC	VGNC:108425
Rattus norvegicus	NDUFA5	RGD	RGD:3155
Mus musculus	NDUFA5	MGD	MGI:1915452

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NDUFA5 - NADH:ubiquinone oxidoreductase subunit A5 Gene

关于 NDUFA5

功能概要

NDUFA5 基因产物(6)

NDUFA5 蛋白结构

NDUFA5 蛋白互作信息

关联疾病

直系同源

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NDUFA5 - NADH:ubiquinone oxidoreductase subunit A5 Gene

关于 NDUFA5

功能概要

NDUFA5 基因产物(6)

NDUFA5 蛋白结构

NDUFA5 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

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