SEPTIN2 - septin 2 Gene

中文名称：败血症 2

种属: Homo sapiens

同用名: DIFF6; NEDD5; SEPT2; NEDD-5; Pnutl3; hNedd5

基因 ID: 4735 | 基因类型: protein coding

关于 SEPTIN2

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,315,355-241,354,027 (from NCBI)

This gene has 45 transcripts (splice variants), 225 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 77.8), thyroid (RPKM 76.6) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性。预计参与多个过程，包括纤毛组装；调节胞吐作用；和平滑的信号通路。预计在调节 L-谷氨酸跨质膜输入和调节蛋白质定位的上游或调节范围内起作用。位于多个细胞成分中，包括细胞骨架；光感受器连接纤毛；和精子环。败血症复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity. Predicted to be involved in several processes, including cilium assembly; regulation of exocytosis; and smoothened signaling pathway. Predicted to act upstream of or within regulation of L-glutamate import across plasma membrane and regulation of protein localization. Located in several cellular components, including cytoskeleton; photoreceptor connecting cilium; and sperm annulus. Part of septin complex. [provided by Alliance of Genome Resources, Apr 2022]

SEPTIN2 基因产物(31)

mRNA	Protein	Name
NM_001008491.3	NP_001008491.1	septin-2 isoform a
NM_001008492.3	NP_001008492.1	septin-2 isoform a
NM_001282972.2	NP_001269901.1	septin-2 isoform b
NM_001282973.2	NP_001269902.1	septin-2 isoform c
NM_001321029.2	NP_001307958.1	septin-2 isoform d
NM_001321030.3	NP_001307959.1	septin-2 isoform a
NM_001321031.2	NP_001307960.1	septin-2 isoform a
NM_001321032.2	NP_001307961.1	septin-2 isoform a
NM_001321033.3	NP_001307962.1	septin-2 isoform a
NM_001321034.2	NP_001307963.1	septin-2 isoform a
NM_001321035.2	NP_001307964.1	septin-2 isoform a
NM_001349287.2	NP_001336216.1	septin-2 isoform e
NM_001349288.2	NP_001336217.1	septin-2 isoform c
NM_001349289.2	NP_001336218.1	septin-2 isoform a
NM_001349290.2	NP_001336219.1	septin-2 isoform a
NM_001349291.2	NP_001336220.1	septin-2 isoform a
NM_001349302.2	NP_001336231.1	septin-2 isoform f
NM_001349304.2	NP_001336233.1	septin-2 isoform g
NM_001349305.2	NP_001336234.1	septin-2 isoform g
NM_001349306.2	NP_001336235.1	septin-2 isoform g
NM_001349307.2	NP_001336236.1	septin-2 isoform h
NM_001349308.2	NP_001336237.1	septin-2 isoform h
NM_001349309.2	NP_001336238.1	septin-2 isoform h
NM_001349310.2	NP_001336239.1	septin-2 isoform h
NM_001349311.2	NP_001336240.1	septin-2 isoform h
NM_001349312.2	NP_001336241.1	septin-2 isoform h
NM_001349313.2	NP_001336242.1	septin-2 isoform h
NM_001349314.2	NP_001336243.1	septin-2 isoform h
NM_001349315.2	NP_001336244.1	septin-2 isoform h
NM_004404.5	NP_004395.1	septin-2 isoform a
NM_006155.3	NP_006146.1	septin-2 isoform a

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17637674	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10321247	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in axoneme	IDA IDA: 通过直接分析推断	23572511	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	10942595	GOA
located in non-motile cilium	IDA IDA: 通过直接分析推断	23572511	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10942595	GOA
located in photoreceptor connecting cilium	IDA IDA: 通过直接分析推断	23572511	GOA
part of septin complex	IDA IDA: 通过直接分析推断	23572511	GOA
located in sperm annulus	IDA IDA: 通过直接分析推断	25588830	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEPTIN2 蛋白结构

Septin

0
100
200
300
361 a.a.

蛋白主名

其他名称

septin-2

epididymis secretory sperm binding protein

SEPTIN2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SEPTIN2	Q15019	SEPTIN5	Homo sapiens	Q99719	Anti Tag CoIP	35271311
种属内	SEPTIN2	Q15019	SEPTIN5	Homo sapiens	Q99719	Validated Y2H	25416956
种属内	SEPTIN2	Q15019	SEPTIN5	Homo sapiens	Q99719	Y2H Array	25416956
种属内	SEPTIN2	Q15019	SEPTIN5	Homo sapiens	Q99719	Anti Tag CoIP	33961781
种属内	SEPTIN2	Q15019	SEPTIN6	Homo sapiens	Q14141	Anti Tag CoIP	35271311
种属内	SEPTIN2	Q15019	SEPTIN6	Homo sapiens	Q14141	Y2H Pooling	16189514
种属内	SEPTIN2	Q15019	SEPTIN6	Homo sapiens	Q14141	Anti Tag CoIP	33961781
种属内	SEPTIN2	Q15019	SEPTIN6	Homo sapiens	Q14141	IF	25588830
种属内	SEPTIN2	Q15019	SEPTIN6	Homo sapiens	Q14141	Validated Y2H	25416956
种属内	SEPTIN2	Q15019	SEPTIN9	Homo sapiens	Q9UHD8	Anti Tag CoIP	35271311
种属内	SEPTIN2	Q15019	SEPTIN9	Homo sapiens	Q9UHD8	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

SEPTIN2 抗体

目录号	产品名	应用	反应物种
HY-P82509	Septin 2 Antibody (YA2254)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Integrative Agnosia

Pineal Region Meningioma

Pineal Meningioma

Progressive Myoclonus Epilepsy 10

Early-Onset Lafora Body Disease

Epm10

Acquired Color Blindness

Acquired Color Vision Deficiencies	Acquired Color Vision Deficiency
Acquired Colour Blindness	Acquired Colour Vision Deficiencies
Acquired Colour Vision Deficiency

Amyotrophic Neuralgia

Neuralgic Amyotrophy	Brachial Plexus Neuritis
Neuralgic Shoulder Amyotrophy	Acute Brachial Plexus Neuritis
Immune Brachial Plexus Neuropathy	Mononeuritis Multiplex With Brachial Predilection
Parsonage-Turner Syndrome

Brachial Plexus Neuropathy

Brachial Plexopathy	Brachial Plexus Neuropathies
Brachial Plexus Disorder	Bpn - [Brachial Plexus Neuropathy]
Brachial Plexus Disease	Neuropathic Plexus Brachialis
Brachial Plexus Syndrome	Brachial Plexus Irritation
Brachial Plexus Lesion	Brachial Plexus Pressure
Compression Of Brachial Plexus

Intracranial Hypotension

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12682	SEPTIN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SEPTIN2	VGNC	VGNC:68451
Rattus norvegicus	SEPTIN2	RGD	RGD:620056
Macaca mulatta	SEPTIN2	VGNC	VGNC:77359
Bos taurus	SEPTIN2	VGNC	VGNC:34454
Canis familiaris	SEPTIN2	VGNC	VGNC:46014
Mus musculus	SEPTIN2	MGD	MGI:97298

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SEPTIN2 - septin 2 Gene

关于 SEPTIN2

功能概要

SEPTIN2 基因产物(31)

SEPTIN2 蛋白结构

SEPTIN2 蛋白互作信息

SEPTIN2 抗体

关联疾病

直系同源

热门区域

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SEPTIN2 - septin 2 Gene

关于 SEPTIN2

功能概要

SEPTIN2 基因产物(31)

SEPTIN2 蛋白结构

SEPTIN2 蛋白互作信息

SEPTIN2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z