2. Gene
  3. INO80 - INO80 complex ATPase subunit Gene

INO80 - INO80 complex ATPase subunit Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：INO80 复合 ATP 酶亚基

种属: Homo sapiens

同用名: INOC1; INO80A

基因 ID: 54617 | 基因类型: protein coding

关于 INO80

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,978,880-41,116,280 (from NCBI)

This gene has 17 transcripts (splice variants), 201 orthologues, 30 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 5.6), testis (RPKM 5.5) and 25 other tissues.

功能概要

该基因编码染色质重塑复合物的一个亚基，除保守的 ATPase 结构域外，该亚基根据序列特征分为亚家族。该蛋白质是 INO80 染色质重塑复合物的催化 ATP 酶亚基，其特征在于 DNA 结合域。该蛋白质被提议结合 DNA 并被 YY1 转录因子募集以激活某些基因。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 8 月]

This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

INO80 基因产物(1)

mRNA Protein Name
NM_017553.3 NP_060023.1 chromatin-remodeling ATPase INO80
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP-dependent activity, acting on DNA IDA
IDA: 通过直接分析推断
16298340 GOA
enables DNA binding IDA
IDA: 通过直接分析推断
16298340 GOA
enables alpha-tubulin binding IMP
IMP: 通过突变表型推断
20237820 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18026119 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in UV-damage excision repair IMP
IMP: 通过突变表型推断
20855601 GOA
involved in cellular response to UV IMP
IMP: 通过突变表型推断
18026119 GOA
involved in cellular response to ionizing radiation IMP
IMP: 通过突变表型推断
20687897 GOA
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
21303910 GOA
involved in double-strand break repair IMP
IMP: 通过突变表型推断
20687897 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
18026119 GOA
involved in mitotic sister chromatid segregation IMP
IMP: 通过突变表型推断
20237820 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
27641337 GOA
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
20237820 GOA
involved in positive regulation of nuclear cell cycle DNA replication IMP
IMP: 通过突变表型推断
20237820 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20687897 GOA
involved in regulation of DNA replication IMP
IMP: 通过突变表型推断
25016522 GOA
involved in regulation of DNA strand elongation IMP
IMP: 通过突变表型推断
25016522 GOA
involved in regulation of G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
20237820 GOA
involved in regulation of cell cycle IMP
IMP: 通过突变表型推断
26340092 GOA
involved in regulation of chromosome organization IMP
IMP: 通过突变表型推断
26340092 GOA
involved in spindle assembly IMP
IMP: 通过突变表型推断
20237820 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Ino80 complex IDA
IDA: 通过直接分析推断
18026119 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16298340 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

INO80 蛋白结构

DBINO

DBINO: DNA-binding domain (271 - 405)

SNF2_N

SNF2_N: SNF2 family N-terminal domain (521 - 822)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (1140 - 1214)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1556 a.a.
蛋白主名 其他名称

chromatin-remodeling ATPase INO80

DNA helicase INO80

INO80 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra INO80 Q9ULG1 DDB1 Homo sapiens Q16531
Anti Bait CoIP
20855601
Intra INO80 Q9ULG1 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra INO80 Q9ULG1 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Intra INO80 Q9ULG1 YY1 Homo sapiens P25490
Anti Tag CoIP
33961781
Intra INO80 Q9ULG1 ACTR5 Homo sapiens Q9H9F9
Anti Tag CoIP
33961781
Intra INO80 Q9ULG1 ACTR5 Homo sapiens Q9H9F9
Anti Tag CoIP
35271311
Intra INO80 Q9ULG1 ACTR5 Homo sapiens Q9H9F9
Anti Tag CoIP
19014934
Intra INO80 Q9ULG1 ACTR5 Homo sapiens Q9H9F9
Anti Bait CoIP
20855601
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Combined Cellular And Humoral Immune Defects With Granulomas

Combined Immunodeficiency With Skin Granulomas

CCHIDG

Cid Due To Rag 1/2 Deficiency

Combined Immunodeficiency Due To Rag 1/2 Deficiency

Combined Immunodeficiency With Granulomatosis

CHIDG

Immune Defects, Combined Cellular And Humoral With Granulomas
Primary Microcephaly

True Microcephaly

Microcephaly, Primary
Grange Syndrome

Arterial Occlusive Disease, Progressive, With Hypertension, Heart Defects, Bone Fragility, And Brachysyndactyly

Grange Occlusive Arterial Syndrome

GRNG

Progressive Arterial Occlusive Disease-Hypertension-Heart Defects-Bone Fragility-Brachysyndactyly Syndrome
Fibromuscular Dysplasia
Floating-Harbor Syndrome

FLHS

Fhs

Pelletier-Leisti Syndrome

Short Stature With Delayed Bone Age, Expressive Language Delay, A Triangular Face With A Prominent Nose And Deep-Set Eyes

Leisti-Hollander-Rimoin Syndrome
Immunodeficiency 43

Hypoproteinemia, Hypercatabolic

IMD43

Beta-2-Microglobulin Deficiency

B2m Deficiency

Hypercatabolic Hypoproteinemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06821 INO80 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06822 INO80D Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06823 INO80E Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus INO80 VGNC VGNC:30205
Rattus norvegicus INO80 RGD RGD:1310969
Macaca mulatta INO80 VGNC VGNC:84358
Mus musculus INO80 MGD MGI:1915392
Felis catus INO80 VGNC VGNC:62926
Canis familiaris INO80 VGNC VGNC:42024
Others INO80 NCBI
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