2. Gene
  3. IRX6 - iroquois homeobox 6 Gene

IRX6 - iroquois homeobox 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：易洛魁人同源框 6

种属: Homo sapiens

同用名: IRX7; IRX-3; IRXB3

基因 ID: 79190 | 基因类型: protein coding

关于 IRX6

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,324,203-55,330,756 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 6 paralogues. Biased expression in fat (RPKM 7.9), heart (RPKM 3.1) and 5 other tissues.

功能概要

预测启用 DNA 结合转录激活因子活性，RNA 聚合酶 II 特异性； DNA 结合转录抑制活性，RNA 聚合酶 II 特异性；和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。预计参与细胞发育；神经元分化；和转录调控，DNA 模板化。预计在可见光检测的上游或检测范围内起作用；转录的负调控，DNA 模板化；和相机型眼睛的视网膜形态发生。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; neuron differentiation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within detection of visible light; negative regulation of transcription, DNA-templated; and retina morphogenesis in camera-type eye. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

IRX6 基因产物(1)

mRNA Protein Name
NM_024335.3 NP_077311.2 iroquois-class homeodomain protein IRX-6
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IRX6 蛋白结构

Homeobox_KN

Homeobox_KN: Homeobox KN domain (164 - 203)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 446 a.a.
蛋白主名 其他名称

iroquois-class homeodomain protein IRX-6

homeodomain protein IRXB3

IRX6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IRX6 P78412 KRTAP19-7 Homo sapiens Q3SYF9
Validated Y2H
32296183
种属内
IRX6 P78412 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
32296183
种属内
IRX6 P78412 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
种属内
IRX6 P78412 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
种属内
IRX6 P78412 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
种属内
IRX6 P78412 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
种属内
IRX6 P78412 TBX19 Homo sapiens O60806
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 TBX19 Homo sapiens O60806
Y2H Array
32296183
种属内
IRX6 P78412 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
IRX6 P78412 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
IRX6 P78412 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
种属内
IRX6 P78412 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
种属内
IRX6 P78412 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 GLRX3 Homo sapiens O76003
Y2H Array
32296183
种属内
IRX6 P78412 TRIB3 Homo sapiens Q96RU7
Validated Y2H
32296183
种属内
IRX6 P78412 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
种属内
IRX6 P78412 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 MYL2 Homo sapiens P10916
Y2H Array
32296183
种属内
IRX6 P78412 MYL2 Homo sapiens P10916
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 HOXA1 Homo sapiens P49639
Y2H Array
32296183
种属内
IRX6 P78412 CRX Homo sapiens O43186
Y2H Array
32296183
种属内
IRX6 P78412 CRX Homo sapiens O43186
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
种属内
IRX6 P78412 ARID5A Homo sapiens Q03989
Validated Y2H
32296183
种属内
IRX6 P78412 ARID5A Homo sapiens Q03989
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Transient Refractive Change
Aniseikonia
Lateral Displacement Of Eye

Lateral Displacement Of Globe
Cycloplegia

Ciliary Muscle Paresis

Cycloplegic Paralysis Of Accommodation

Paresis Of Accommodation

Visual Accommodation Paralysis

Accommodation Paralysis

Intrinsic Paralysis Of Eye Muscle

Cycloplegic
Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome

Sudden Unexplained Nocturnal Death Syndrome

Bangungut

Brugada Type Idiopathic Ventricular Fibrillation

Pokkuri Death Syndrome

Sunds

Idiopathic Ventricular Fibrillation, Brugada Type

Sudden Unexplained Death

Dream Disease

Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome

Sudden Unexplained Death Syndrome

Suds

Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Eye Accommodation Disease
Cone Dystrophy

Retinal Cone Dystrophy

Dystrophy, Cone

Cone Dystrophy 3
Pulmonary Immaturity

Primary Atelectasis Of Newborn

Primary Atelectasis, In Perinatal Period

Primary Failure To Expand Terminal Respiratory Units

Immature Lungs

Primary Atelectasis

Pulmonary Immaturity Nos

Lung Lobe Hypoplasia, Associated With Short Gestation

Lung Nonexpansion

Premature Lungs

Pulmonary Hypoplasia Associated With Short Gestation

Failure Of Expansion Of Terminal Respiratory Units

Primary Atelectasis Of Fetus Or Newborn

Primary Atelectasis In Perinatal Period
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06925 IRX6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris IRX6 VGNC VGNC:42103
Mus musculus IRX6 MGD MGI:1927642
Macaca mulatta IRX6 VGNC VGNC:73598
Rattus norvegicus IRX6 RGD RGD:1564830
Felis catus IRX6 VGNC VGNC:62973
Bos taurus IRX6 VGNC VGNC:30290
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z