1. Gene
  2. ADAMTSL3 - ADAMTS like 3 Gene

ADAMTSL3 - ADAMTS like 3 Gene

中文名称:亚当斯样 3

种属: Homo sapiens

同用名: ADAMTSL-3

基因 ID: 57188 | 基因类型: protein coding

关于 ADAMTSL3

Cytogenetic location: 15q25.2 Genomic coordinates (GRCh38): 15:83,654,123-84,039,842 (from NCBI)

This gene has 8 transcripts (splice variants), 193 orthologues and 25 paralogues. Broad expression in lung (RPKM 4.5), placenta (RPKM 4.0) and 24 other tissues.

功能概要

预计参与细胞外基质组织。位于细胞内膜界的细胞器中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in extracellular matrix organization. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

ADAMTSL3 基因产物(2)

mRNA Protein Name
NM_001301110.2 NP_001288039.1 ADAMTS-like protein 3 isoform b precursor
NM_207517.3 NP_997400.2 ADAMTS-like protein 3 isoform a precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ADAMTSL3 蛋白结构

TSP_1

TSP_1: Thrombospondin type 1 domain (80 - 123)

TSP_1

TSP_1: Thrombospondin type 1 domain (425 - 452)

TSP_1

TSP_1: Thrombospondin type 1 domain (486 - 508)

TSP_1

TSP_1: Thrombospondin type 1 domain (571 - 608)

TSP_1

TSP_1: Thrombospondin type 1 domain (710 - 759)

TSP_1

TSP_1: Thrombospondin type 1 domain (766 - 801)

TSP_1

TSP_1: Thrombospondin type 1 domain (826 - 880)

Ig_2

Ig_2: Immunoglobulin domain (926 - 986)

Ig_2

Ig_2: Immunoglobulin domain (1211 - 1271)

I-set

I-set: Immunoglobulin I-set domain (1309 - 1382)

TSP_1

TSP_1: Thrombospondin type 1 domain (1431 - 1483)

TSP_1

TSP_1: Thrombospondin type 1 domain (1489 - 1527)

PLAC

PLAC: PLAC (protease and lacunin) domain (1659 - 1689)

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  • 1691 a.a.
蛋白主名 其他名称

ADAMTS-like protein 3

a disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like 3

ADAMTSL3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ADAMTSL3 P82987 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra ADAMTSL3 P82987 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra ADAMTSL3 P82987 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra ADAMTSL3 P82987 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra ADAMTSL3 P82987 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra ADAMTSL3 P82987 KRTAP2-3 Homo sapiens P0C7H8
Validated Y2H
25416956
Intra ADAMTSL3 P82987 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra ADAMTSL3 P82987 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra ADAMTSL3 P82987 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra ADAMTSL3 P82987 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra ADAMTSL3 P82987 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra ADAMTSL3 P82987 KRTAP5-7 Homo sapiens Q6L8G8
Validated Y2H
32296183
Intra ADAMTSL3 P82987 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra ADAMTSL3 P82987 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra ADAMTSL3 P82987 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra ADAMTSL3 P82987 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra ADAMTSL3 P82987 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra ADAMTSL3 P82987 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra ADAMTSL3 P82987 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra ADAMTSL3 P82987 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
32296183
Intra ADAMTSL3 P82987 GLRX3 Homo sapiens O76003
Y2H Array
32296183
Intra ADAMTSL3 P82987 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra ADAMTSL3 P82987 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra ADAMTSL3 P82987 MDFI Homo sapiens Q99750
Validated Y2H
25416956
Intra ADAMTSL3 P82987 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra ADAMTSL3 P82987 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra ADAMTSL3 P82987 MDFI Homo sapiens Q99750
Y2H Array
25416956
Intra ADAMTSL3 P82987 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra ADAMTSL3 P82987 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
32296183
Intra ADAMTSL3 P82987 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Intra ADAMTSL3 P82987 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra ADAMTSL3 P82987 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra ADAMTSL3 P82987 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Radial Nerve Lesion

Lesion Of Radial Nerve

Radial Nerve Lesions

Radial Neuropathy

Radial Nerve Mononeuritis

Geleophysic Dysplasia

Geleophysic Dwarfism

Gphysd

Isolated Ectopia Lentis

Familial Ectopia Lentis

Ectopia Lentis

Ectopia Lentis Syndrome

Lens Subluxation

Iel

Congenital Ectopia Lentis

Subluxation Of Lens

Ectopia Lentis, Isolated

Ectopia Lentis Isolated

Ehlers-Danlos Syndrome, Dermatosparaxis Type

Dermatosparaxis

EDSDERMS

Ehlers-Danlos Syndrome, Type Vii, Autosomal Recessive

Eds Viic

Eds7c

Ehlers-Danlos Syndrome Dermatosparaxis Type

Dermatosparaxis Ehlers-Danlos Syndrome

Dermatosparaxis Eds

Ehlers-Danlos Syndrome Type 7c

Deds

Human Dermatosparaxis Eds Viic

Ehlers-Danlos Syndrome 7c

Ehlers-Danlos Syndrome, Type Viic

Weill-Marchesani Syndrome

Gemss Syndrome

Spherophakia-Brachymorphia Syndrome

Marchesani-Weill Syndrome

Wms

Congenital Mesodermal Dystrophy

Mesodermal Dysmorphodystrophy, Congenital

Spherophakia Brachymorphia Syndrome

Mesodermal Dysmorphodystrophy Congenital

Wm Syndrome

Brachydactyly-Spherophakia Syndrome

Brachymorphy With Spherophakia Syndrome

Congenital Mesodermal Dysmorphodystrophy

Marchesani Syndrome

Weill-Marchesani Syndrome, Autosomal Recessive

Weill-Marchesani Syndrome, Autosomal Dominant

Peters-Plus Syndrome

Krause-Kivlin Syndrome

Peters Plus Syndrome

Peters Anomaly

Irido-Corneo-Trabecular Dysgenesis

PTRPLS

Peters Anomaly With Short-Limb Dwarfism

Peters Anomaly-Short Limb Dwarfism Syndrome

Peters Anomaly With Short Limb Dwarfism

Peters Congenital Glaucoma

Krause-Van Schooneveld-Kivlin Syndrome

Peters' Plus Syndrome

Peters'-Plus Syndrome

Anomaly Peters

Radial Neuropathy
Acromicric Dysplasia

ACMICD

Acromicric Skeletal Dysplasia

Dysplasia, Acromicric

Winchester Syndrome

WNCHRS

Winchester Disease

Winchester-Grossman Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADAMTSL3 RGD RGD:1305155
Macaca mulatta ADAMTSL3 VGNC VGNC:69400
Felis catus ADAMTSL3 VGNC VGNC:59601
Bos taurus ADAMTSL3 VGNC VGNC:58360
Canis familiaris ADAMTSL3 VGNC VGNC:54916
Mus musculus ADAMTSL3 MGD MGI:3028499