2. Gene
  3. MAP4K1 - mitogen-activated protein kinase kinase kinase kinase 1 Gene

MAP4K1 - mitogen-activated protein kinase kinase kinase kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶激酶激酶 1

种属: Homo sapiens

同用名: HPK1

基因 ID: 11184 | 基因类型: protein coding

关于 MAP4K1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,587,641-38,617,953 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 197 orthologues and 35 paralogues. Biased expression in lymph node (RPKM 28.4), spleen (RPKM 19.4) and 10 other tissues.

功能概要

启用 ATP 结合活性和 MAP 激酶激酶激酶活性。涉及几个进程，包括 JNK 级联；细胞对佛波醇 13-乙酸酯 12-肉豆蔻酸酯的反应；和蛋白质磷酸化。位于膜内。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity and MAP kinase kinase kinase kinase activity. Involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

MAP4K1 基因产物(3)

mRNA Protein Name
NM_007181.6 NP_009112.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform 2
XM_011526404.2 XP_011524706.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform X1
NM_001042600.3 NP_001036065.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
8824585 GOA
enables MAP kinase kinase kinase kinase activity IDA
IDA: 通过直接分析推断
11053428 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9346925 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
8824585 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in JNK cascade IDA
IDA: 通过直接分析推断
8824585 GOA
involved in cell population proliferation IMP
IMP: 通过突变表型推断
24362026 GOA
involved in cellular response to phorbol 13-acetate 12-myristate IDA
IDA: 通过直接分析推断
8824585 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
11053428 GOA
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
11053428 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
8824585 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
8824585 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP4K1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (17 - 273)

CNH

CNH: CNH domain (506 - 797)

  • 0
  • 200
  • 400
  • 600
  • 833 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase kinase 1

MAPK/ERK kinase kinase kinase 1

MEK kinase kinase 1

MEKKK 1

hematopoietic progenitor kinase 1

MAP4K1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAP4K1 Q92918 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
31980649
种属内
MAP4K1 Q92918 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
MAP4K1 Q92918 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
MAP4K1 Q92918 ABL1 Homo sapiens P00519
Peptide Array
17474147
种属内
MAP4K1 Q92918 ABL1 Homo sapiens P00519
Y2H
9346925
种属内
MAP4K1 Q92918 NCK1 Homo sapiens P16333
Pull Down
9346925
种属内
MAP4K1 Q92918 NCK1 Homo sapiens P16333
Peptide Array
17474147
种属内
MAP4K1 Q92918 NCK1 Homo sapiens P16333
Y2H
9346925
种属内
MAP4K1 Q92918 GRB2 Homo sapiens P62993
Pull Down
9346925
种属内
MAP4K1 Q92918 GRB2 Homo sapiens P62993
SPR
9346925
种属内
MAP4K1 Q92918 GRB2 Homo sapiens P62993
Y2H
9346925
种属内
MAP4K1 Q92918 GRB2 Homo sapiens P62993
Pull Down
32707033
种属内
MAP4K1 Q92918 GRB2 Homo sapiens P62993
Anti Bait CoIP
9346925
种属内
MAP4K1 Q92918 SLAMF1 Homo sapiens Q13291
Pull Down
20231852
种属内
MAP4K1 Q92918 SLAMF1 Homo sapiens Q13291
Anti Bait CoIP
20231852
种属内
MAP4K1 Q92918 FYN Homo sapiens P06241
Peptide Array
17474147
种属内
MAP4K1 Q92918 PLCG1 Homo sapiens P19174
Anti Bait CoIP
17474147
种属内
MAP4K1 Q92918 PLCG1 Homo sapiens P19174
Fluorescence
17474147
种属内
MAP4K1 Q92918 PIK3R1 Homo sapiens P27986
Peptide Array
17474147
种属内
MAP4K1 Q92918 CRK Homo sapiens P46108
Peptide Array
17474147
种属内
MAP4K1 Q92918 CRKL Homo sapiens P46109
CoIP
9788432
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Melnick-Needles Syndrome

MNS

Melnick-Needles Osteodysplasty

Osteodysplasty Of Melnick And Needles

Osteochondrodysplasias
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-138568 HPK1-IN-3 Inhibitor 99.32% 否
HY-138742 HPK1-IN-7 Inhibitor 99.33% 否
HY-148063 DB0614 98.80% 否
HY-148061 DB1113 99.28% 否
HY-143868 HPK1-IN-27 Inhibitor / 否
HY-143871 HPK1-IN-30 Inhibitor / 否
HY-156509 HPK1-IN-38 Inhibitor / 否
HY-169199 BAY-405 Inhibitor / 否
HY-RS08071 MAP4K1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08072 Map4k1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08073 Map4k1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MAP4K1 MGD MGI:1346882
Bos taurus MAP4K1 VGNC VGNC:31204
Rattus norvegicus MAP4K1 RGD RGD:1305463
Felis catus MAP4K1 VGNC VGNC:97498
Canis familiaris MAP4K1 VGNC VGNC:42981
Others MAP4K1 NCBI
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