2. Gene
  3. DOCK1 - dedicator of cytokinesis 1 Gene

DOCK1 - dedicator of cytokinesis 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞分裂因子 1

种属: Homo sapiens

同用名: ced5; DOCK180

基因 ID: 1793 | 基因类型: protein coding

关于 DOCK1

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:126,905,428-127,452,516 (from NCBI)

This gene has 6 transcripts (splice variants), 226 orthologues and 10 paralogues. Ubiquitous expression in thyroid (RPKM 10.9), skin (RPKM 10.0) and 24 other tissues.

功能概要

该基因编码胞质分裂蛋白家族的一个成员。胞质分裂蛋白的奉献者作为小 Rho 家族 G 蛋白的鸟嘌呤核苷酸交换因子。编码的蛋白质调节小 GTPase Rac，从而影响几个生物过程，包括吞噬作用和细胞迁移。该基因的过度表达也与某些癌症有关。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 3 月]

This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

DOCK1 基因产物(14)

mRNA Protein Name
NM_001290223.2 NP_001277152.2 dedicator of cytokinesis protein 1 isoform 1
NM_001377543.1 NP_001364472.1 dedicator of cytokinesis protein 1 isoform 3
NM_001377544.1 NP_001364473.1 dedicator of cytokinesis protein 1 isoform 4
NM_001377546.1 NP_001364475.1 dedicator of cytokinesis protein 1 isoform 5
NM_001377547.1 NP_001364476.1 dedicator of cytokinesis protein 1 isoform 6
NM_001377548.1 NP_001364477.1 dedicator of cytokinesis protein 1 isoform 7
NM_001377550.1 NP_001364479.1 dedicator of cytokinesis protein 1 isoform 8
NM_001377553.1 NP_001364482.1 dedicator of cytokinesis protein 1 isoform 9
NM_001377554.1 NP_001364483.1 dedicator of cytokinesis protein 1 isoform 10
NM_001377556.1 NP_001364485.1 dedicator of cytokinesis protein 1 isoform 11
NM_001377558.1 NP_001364487.1 dedicator of cytokinesis protein 1 isoform 12
NM_001377560.1 NP_001364489.1 dedicator of cytokinesis protein 1 isoform 13
NM_001377561.1 NP_001364490.1 dedicator of cytokinesis protein 1 isoform 14
NM_001380.5 NP_001371.2 dedicator of cytokinesis protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
12134158 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12134158 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
19004829 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
19004829 GOA
involved in regulation of postsynapse assembly IDA
IDA: 通过直接分析推断
21900250 GOA
involved in regulation of postsynapse assembly IMP
IMP: 通过突变表型推断
21900250 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17515907 GOA
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
21900250 GOA
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
21900250 GOA
part of guanyl-nucleotide exchange factor complex IDA
IDA: 通过直接分析推断
12134158 GOA
is active in postsynapse IDA
IDA: 通过直接分析推断
21900250 GOA
is active in postsynapse IMP
IMP: 通过突变表型推断
21900250 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DOCK1 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (16 - 65)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (420 - 619)

DHR-2

DHR-2: Dock homology region 2 (1427 - 1609)

  • 0
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  • 1500
  • 1865 a.a.
蛋白主名 其他名称

dedicator of cytokinesis protein 1

180 kDa protein downstream of CRK

DOCK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DOCK1 Q14185 DOCK5 Homo sapiens Q9H7D0-1
Anti Tag CoIP
32203420
种属内
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Anti Tag CoIP
15247908
种属内
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Pull Down
18768751
种属内
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Anti Tag CoIP
12134158
种属内
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Pull Down
15723800
种属内
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Anti Tag CoIP
18768751
种属内
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Anti Tag CoIP
15723800
种属内
DOCK1 Q14185 ANKRD28 Homo sapiens O15084
Anti Tag CoIP
19118547
种属内
DOCK1 Q14185 GRB2 Homo sapiens P62993
Y2H Pooling
20936779
种属内
DOCK1 Q14185 RAC1 Homo sapiens P63000
Pull Down
12134158
种属内
DOCK1 Q14185 RAC1 Homo sapiens P63000
Pull Down
15723800
种属内
DOCK1 Q14185 RAC1 Homo sapiens P63000
Anti Tag CoIP
12134158
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chromosome 10q26 Deletion Syndrome

Distal 10q Deletion Syndrome

Terminal Chromosome 10q26 Deletion Syndrome

Distal Monosomy 10q

Monosomy 10qter

Telomeric Deletion 10q

Distal Deletion 10q

10q26 Deletion Syndrome

10qter Deletion

Telomeric Deletion 10
Immunodeficiency 40

Dock2 Deficiency

IMD40

Immunodeficiency, Type 40
Spinocerebellar Ataxia, Autosomal Recessive 15

Autosomal Recessive Spinocerebellar Ataxia 15

SCAR15

Salih Ataxia

Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Rubcn Deficiency

Autosomal Recessive Spinocerebellar Ataxia Type 15

Spinocerebellar Ataxia, Autosomal Recessive, 15

Ataxia, Spinocerebellar, Autosomal Recessive, Type 15
Stereotypic Movement Disorder

Stereotypy Habit Disorder

Stereotyped Repetitive Movements

Stereotyped Disorder

Stereotypes Nos

Stereotype Habit Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136177 Tris(2,4-di-tert-butylphenyl)phosphate Inhibitor 99.81% 否
HY-124711 TBOPP Inhibitor 99.96% 否
HY-RS03921 DOCK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DOCK1 VGNC VGNC:28154
Macaca mulatta DOCK1 VGNC VGNC:71965
Mus musculus DOCK1 MGD MGI:2429765
Rattus norvegicus DOCK1 RGD RGD:1566072
Felis catus DOCK1 VGNC VGNC:97403
Canis familiaris DOCK1 VGNC VGNC:40043
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