GRK2 - G protein-coupled receptor kinase 2 Gene

中文名称：G 蛋白偶联受体激酶 2

种属: Homo sapiens

同用名: BARK1; ADRBK1; BETA-ARK1

基因 ID: 156 | 基因类型: protein coding

关于 GRK2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,266,473-67,286,556 (from NCBI)

This gene has 14 transcripts (splice variants), 128 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 91.8), spleen (RPKM 61.9) and 24 other tissues.

功能概要

该基因编码 G 蛋白偶联受体激酶蛋白家族的成员。编码的蛋白质磷酸化 β-肾上腺素能受体以及广泛的其他底物，包括非 GPCR 细胞表面受体，以及细胞骨架、线粒体和转录因子蛋白。来自啮齿动物模型的数据支持该基因在胚胎发育、心脏功能和新陈代谢中的作用。已在患有心力衰竭和阿尔茨海默氏病的人类患者中观察到该基因表达升高。[RefSeq 提供，2017 年 9 月]

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]

GRK2 基因产物(1)

mRNA	Protein	Name
NM_001619.5	NP_001610.2	beta-adrenergic receptor kinase 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables Edg-2 lysophosphatidic acid receptor binding	IDA IDA: 通过直接分析推断	19306925	GOA
enables G protein-coupled receptor kinase activity	IMP IMP: 通过突变表型推断	15102938	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17006543	GOA
enables protein kinase activity	IMP IMP: 通过突变表型推断	21983013	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cardiac muscle contraction	IMP IMP: 通过突变表型推断	15051637	GOA
involved in desensitization of G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	15102938	GOA
involved in negative regulation of relaxation of smooth muscle	IMP IMP: 通过突变表型推断	30284927	GOA
involved in negative regulation of striated muscle contraction	IMP IMP: 通过突变表型推断	15051637	GOA
involved in negative regulation of the force of heart contraction by chemical signal	IMP IMP: 通过突变表型推断	15051637	GOA
involved in receptor internalization	IDA IDA: 通过直接分析推断	20074556	GOA
involved in symbiont entry into host cell	IMP IMP: 通过突变表型推断	23029581	GOA
involved in tachykinin receptor signaling pathway	IDA IDA: 通过直接分析推断	17986524	GOA
involved in viral genome replication	IMP IMP: 通过突变表型推断	23029581	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17986524	GOA
located in cytoplasmic side of mitochondrial outer membrane	IDA IDA: 通过直接分析推断	21983013	GOA
located in cytosol	IDA IDA: 通过直接分析推断	21983013	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GRK2 蛋白结构

RGS

Pkinase

0
200
400
600
689 a.a.

蛋白主名

其他名称

beta-adrenergic receptor kinase 1

adrenergic beta receptor kinase 1

关联疾病

疾病名称

别名

Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy	Jeune Syndrome
Asphyxiating Thoracic Dysplasia	Short-Rib Thoracic Dysplasia With Or Without Polydactyly
Thoracic Pelvic Phalangeal Dystrophy	Asphyxiating Thoracic Chondrodystrophy
Atd	Chondroectodermal Dysplasia-Like Syndrome
Infantile Thoracic Dystrophy	Jeune Thoracic Dysplasia
Thoracic Asphyxiant Dystrophy	Thoracic-Pelvic-Phalangeal Dystrophy
Short-Rib Thoracic Dysplasia Without Polydactyly	Asphyxiating Thoracic Dystrophy Of The Newborn
Asphyxiating Thorax Dystrophy

Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 1	Jeune Syndrome
SRTD1	Atd1
Asphyxiating Thoracic Dystrophy Of The Newborn	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Thoracic-Pelvic-Phalangeal Dystrophy
Atd	Asphyxiating Thoracic Dystrophy
Chondroectodermal Dysplasia-Like Syndrome	Infantile Thoracic Dystrophy
Jeune'S Syndrome	Thoracic Pelvic Phalangeal Dystrophy
Jeune Thoracic Dystrophy

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-B0492	Paroxetine hydrochloride		99.96%	否
HY-B0492A	Paroxetine hydrochloride hemihydrate		99.96%	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-103045	CMPD101	Inhibitor	98.95%	否
HY-W013411A	Locostatin	Inhibitor	99.82%	否
HY-18991	CCG215022	Inhibitor	98.69%	否
HY-109562A	CCG258208 hydrochloride		98.05%	否
HY-18990	GSK180736A	Inhibitor	98.01%	否
HY-47573	CCG273441	Inhibitor	98.67%	否
HY-156863	GRK2 Inhibitor 2	Inhibitor	98.88%	否
HY-123538	GRK2 Inhibitor 1	Inhibitor	98.03%	否
HY-139690	CCG258747	Inhibitor	99.17%	否
HY-P1396A	GRK2i TFA	Inhibitor	98.41%	否
HY-129118	Takeda103A		98.69%	否
HY-109562	CCG258208		/	否
HY-118046	GSK2163632A	Inhibitor	/	否
HY-119232	GSK466317A	Inhibitor	/	否
HY-150022	GRK5-IN-4	Inhibitor	/	否
HY-150039	CCG-271423	Inhibitor	/	否
HY-151216S	rel-Paroxetine-d4 hydrochloride		/	否
HY-155099	FGH31	Agonist	/	否
HY-B0492S1	Paroxetine-d4 hydrochloride		99.16%	否
HY-P1396	GRK2i	Inhibitor	/	否
HY-RS05813	GRK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-103045A	CMPD101 hydrochloride	Inhibitor	/	否
HY-123254	CCG-224406	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	GRK2	VGNC	VGNC:73253
Rattus norvegicus	GRK2	RGD	RGD:2062
Mus musculus	GRK2	MGD	MGI:87940
Canis familiaris	GRK2	VGNC	VGNC:41502
Bos taurus	GRK2	VGNC	VGNC:56266
Felis catus	GRK2	VGNC	VGNC:62718

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GRK2 - G protein-coupled receptor kinase 2 Gene

关于 GRK2

功能概要

GRK2 基因产物(1)

GRK2 蛋白结构

关联疾病

直系同源

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GRK2 - G protein-coupled receptor kinase 2 Gene

关于 GRK2

功能概要

GRK2 基因产物(1)

GRK2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z