2. Gene
  3. FPR1 - formyl peptide receptor 1 Gene

FPR1 - formyl peptide receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：甲酰肽受体 1

种属: Homo sapiens

同用名: FPR; FMLP

基因 ID: 2357 | 基因类型: protein coding

关于 FPR1

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,745,172-51,751,878 (from NCBI)

This gene has 4 transcripts (splice variants), 96 orthologues, 8 paralogues and is associated with 1 phenotype. Biased expression in appendix (RPKM 94.6), bone marrow (RPKM 64.2) and 9 other tissues.

功能概要

该基因编码哺乳动物吞噬细胞的 G 蛋白偶联受体，该受体是 G 蛋白偶联受体 1 家族的成员。该蛋白介导吞噬细胞对微生物入侵宿主的反应，在宿主防御和炎症中起重要作用。[RefSeq 提供，2010 年 7 月]

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by Microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

FPR1 基因产物(2)

mRNA Protein Name
NM_001193306.2 NP_001180235.1 fMet-Leu-Phe receptor
NM_002029.4 NP_002020.1 fMet-Leu-Phe receptor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
15210802 GOA
enables G protein-coupled receptor binding IDA
IDA: 通过直接分析推断
10823817 GOA
enables N-formyl peptide receptor activity IDA
IDA: 通过直接分析推断
12218158 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22447027 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
22859307 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FPR1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (43 - 301)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
蛋白主名 其他名称

fMet-Leu-Phe receptor

N-formylpeptide chemoattractant receptor

关联疾病

疾病名称 别名
Susceptibility To Localized Juvenile Periodontitis
Plague

Yersiniosis

Yersinia Infections

Infection By Yersinia Pestis

Pasteurella Pestis Infection

Pestilential Fever

Yersinia Pestis Infection
Pertussis

Whooping Cough

Bordetella Infections

Bordetella Infection

Bordetella Pertussis Infection

Wc - Whooping Cough

Whooping Cough Due To Unspecified Organism

Bordetellosis

Tussis Convulsiva

Whooping Cough, Unspecified Organism

Wc - [Whooping Cough]

Whooping Cough Due To B. Parapertussis

Infection Due To Bordetella Parapertussis
Aggressive Periodontitis

Juvenile Periodontitis

Periodontitis, Juvenile

Prepubertal Periodontitis
Periodontitis, Aggressive, 1

Pustulosis Palmaris Et Plantaris

Ppp

Periodontitis, Juvenile

Localized Pustular Psoriasis

Jpd

Periodontitis 1, Juvenile

Lpp

Palmoplantar Pustulosis

Prepubertal Periodontitis

Periodontitis, Aggressive 1

Periodontitis, Prepubertal

Periodontititis, Aggressive, 1

AP1

Juvenile Periodontitis

Periodontitis Juvenile

Pustulosis Of Palms And Soles

Generalized Pustular Psoriasis
Diamond-Blackfan Anemia 2

DBA2

Anemia, Diamond-Blackfan, 2

Anemia Diamond-Blackfan 2
Pulmonary Coin Lesion

Coin Lesion Of Lung

Solitary Pulmonary Nodule

Coin Lesion Lung
Hyper Ige Syndrome

Hyper-Ige Syndrome

Hyper Immunoglobulin E Syndrome

Hies

Hyper-Ige Recurrent Infection Syndrome

Hyperimmunoglobulin E Syndrome

Hyper Ige

Job Syndrome

Hartnup Disease
Anaerobic Meningitis
Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder
Rubeosis Iridis
High Grade Glioma

Malignant Glioma

Glial Cell Tumor

Glioma, Malignant

Malignant Neuroglial Tumor

Neuroglial Tumor

Glioma

Malignant Gliomas
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (22)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1122 Cyclosporin H 99.43% 否
HY-101283 HCH6-1 99.14% 否
HY-103286 PD176252 Antagonist 99.38% 否
HY-P1795 N-Boc-Phe-Leu-Phe-Leu-Phe 98.05% 否
HY-116216 PD 168368 Antagonist ≥99.0% 否
HY-P1121A WKYMVM-NH2 TFA 99.67% 否
HY-19574 FPR Agonist 43 99.79% 否
HY-128113 AG-09/1 99.79% 否
HY-N8152 Randialic acid B Inhibitor 99.94% 否
HY-P1116A PBP10 TFA Inhibitor 98.14% 否
HY-156293 FPR1 antagonist 1 ≥95.0% 否
HY-144604 FPR2 agonist 2 Agonist 99.59% 否
HY-P1117 MMK1 99.22% 否
HY-P1744 N-Formyl-Met-Leu-Phe-Lys 98.98% 否
HY-P1118 Ac9-25 98.54% 否
HY-117971 BVT173187 / 否
HY-156294 FPR1 antagonist 2 / 否
HY-P10724 fMIFL Agonist / 否
HY-P1116 PBP10 Inhibitor / 否
HY-P1117A MMK1 TFA / 否
HY-P1118A Ac9-25 TFA / 否
HY-RS05085 FPR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FPR1 VGNC VGNC:109505
Rattus norvegicus FPR1 RGD RGD:1310883
Mus musculus FPR1 MGD MGI:107443
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