2. Epigenetics TGF-beta/Smad Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton
  3. PKC ROCK
  4. CMPD101 hydrochloride

CMPD101 hydrochloride，一种具有膜通透性，GRK2 和 GRK3 的小分子抑制剂，IC50 值分别为 18 nM 和 5.4 nM。CMPD101 hydrochloride 还抑制Rho相关激酶 2 (ROCK-2) 和 PKCα，IC50值分别为 1.4 μM 和 8.1 μM。

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CMPD101 hydrochloride Chemical Structure

CMPD101 hydrochloride Chemical Structure

CAS No. : 1941168-71-3

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CMPD101 hydrochloride 的其他形式现货产品:

Other Forms of CMPD101 hydrochloride:

CMPD101 hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

查看 ROCK 亚型特异性产品:

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ROCK ROCK1 ROCK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CMPD101 hydrochloride is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM, respectively. CMPD101 hydrochloride also inhibits Rho-associated kinase 2 (ROCK-2) and PKCα (IC50s =1.4 μM and 8.1 μM, respectively)[1].

IC50 & Target[1]

PKCα

8.1 μM (IC50)

ROCK2

1.4 μM (IC50)

分子量

502.92

Formula

C24H22ClF3N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CMPD101 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CMPD1011941168-71-3CMPD 101CMPD-101PKCROCKProtein kinase CRho-associated protein kinaseRho-associated kinaseRho-kinaseROKInhibitorinhibitorinhibit

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