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AL-GDa62 可用于研究胃癌的潜在合成致死疗法。AL-GDa62 对同基因乳腺上皮细胞 MCF10A-WT（野生型）和 突变型 MCF10A-CDH1-/- 的 EC50 分别为 3.2 μM 和 2 μM。

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AL-GDa62 Chemical Structure

AL-GDa62 Chemical Structure

CAS No. : 2761538-66-1

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AL-GDa62 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AL-GDa62 acts as a potential synthetic lethal lead for the research of gastric cancer. AL-GDa62 shows EC50 of 3.2 μM and 2 μM for isogenic mammary epithelial cells MCF10A-WT (wild-type) and MCF10A-CDH1-/-[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF-10A EC50
2 μM
Compound: 3;AL-GDa62
Antitumor activity against human spontaneously immortalized CDH-/- MCF10A cells assessed as cell numbers measured after 48 hrs
Antitumor activity against human spontaneously immortalized CDH-/- MCF10A cells assessed as cell numbers measured after 48 hrs
[PMID: 34878770]
MCF-10A EC50
3.2 μM
Compound: 3;AL-GDa62
Antitumor activity against human spontaneously immortalized wild type MCF-10A cells assessed as cell numbers measured after 48 hrs
Antitumor activity against human spontaneously immortalized wild type MCF-10A cells assessed as cell numbers measured after 48 hrs
[PMID: 34878770]
NCI-N87 EC50
16.35 μM
Compound: 3;AL-GDa62
Antitumor activity against human CDH-/- NCI-N87cells assessed as cell numbers measured after 48 hrs
Antitumor activity against human CDH-/- NCI-N87cells assessed as cell numbers measured after 48 hrs
[PMID: 34878770]
NCI-N87 EC50
8.5 μM
Compound: 3;AL-GDa62
Antitumor activity against human wild type NCI-N87 cells assessed as cell numbers measured after 48 hrs
Antitumor activity against human wild type NCI-N87 cells assessed as cell numbers measured after 48 hrs
[PMID: 34878770]
分子量

393.50

Formula

C24H28FN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AL-GDa62 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AL-GDa622761538-66-1Otherssynthetic lethal leadgastric cancerisogenic mammary epithelial cellsMCF10A-WTInhibitorinhibitorinhibit

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