2. Gene
  3. NFATC4 - nuclear factor of activated T cells 4 Gene

NFATC4 - nuclear factor of activated T cells 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：活化 T 细胞核因子 4

种属: Homo sapiens

同用名: NFAT3; NF-AT3; NF-ATC4

基因 ID: 4776 | 基因类型: protein coding

关于 NFATC4

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,366,911-24,379,604 (from NCBI)

This gene has 33 transcripts (splice variants), 1 gene allele, 182 orthologues and 4 paralogues. Broad expression in ovary (RPKM 15.2), endometrium (RPKM 13.8) and 22 other tissues.

功能概要

该基因编码活化 T 细胞核因子 (NFAT) 蛋白家族的成员。编码的蛋白质是 DNA 结合转录复合物的一部分。该复合物至少由两个成分组成：在 T 细胞受体刺激后转移到细胞核的预先存在的胞质成分和可诱导的核成分。 NFAT 蛋白被钙调蛋白依赖性磷酸酶、神经钙蛋白激活。所编码的蛋白质在 T 细胞中细胞因子基因的诱导表达中发挥作用，特别是在白细胞介素 2 和白细胞介素 4 的诱导中。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 1 月]

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent Phosphatase, Calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

NFATC4 基因产物(9)

mRNA Protein Name
NM_001136022.3 NP_001129494.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 1
NM_001198965.2 NP_001185894.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 3
NM_001198966.2 NP_001185895.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 4
NM_001198967.3 NP_001185896.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 5
NM_001288802.2 NP_001275731.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 6
NM_001320043.2 NP_001306972.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 7
NM_001363681.1 NP_001350610.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 8
NM_001363682.1 NP_001350611.1 nuclear factor of activated T-cells, cytoplasmic 4 isoform 9
NM_004554.5 NP_004545.2 nuclear factor of activated T-cells, cytoplasmic 4 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
IGI: 通过遗传相互作用推断
23543060 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18218901 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of miRNA transcription IGI
IGI: 通过遗传相互作用推断
23543060 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12370307 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NFATC4 蛋白结构

RHD_DNA_bind

RHD_DNA_bind: Rel homology DNA-binding domain (419 - 578)

TIG

TIG: IPT/TIG domain (586 - 682)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 902 a.a.
蛋白主名 其他名称

nuclear factor of activated T-cells, cytoplasmic 4

T-cell transcription factor NFAT3

NFATC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NFATC4 Q14934 UBC Homo sapiens P0CG48
Pull Down
19026640
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukostasis
Noonan Syndrome With Multiple Lentigines

Leopard Syndrome

Multiple Lentigines Syndrome

Moynahan Syndrome

Cardiomyopathic Lentiginosis

Progressive Cardiomyopathic Lentiginosis

Cardio-Cutaneous Syndrome

Lentiginosis Profusa

Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

Generalized Lentiginosis

Gorlin Syndrome Ii

Lentiginosis Profusa Syndrome

Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

Diffuse Lentiginosis

Nsml

Familial Multiple Lentigines Syndrome

Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

Progressive Cardiomyopathic Lentiginosis Syndrome

Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome
Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P0254 Kisspeptin-10, human 99.68% 否
HY-P0254A Kisspeptin-10, human TFA 95.89% 否
HY-RS09242 NFATC4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NFATC4 MGD MGI:1920431
Felis catus NFATC4 VGNC VGNC:68472
Rattus norvegicus NFATC4 RGD RGD:1310749
Bos taurus NFATC4 VGNC VGNC:54464
Canis familiaris NFATC4 VGNC VGNC:43770
Macaca mulatta NFATC4 VGNC VGNC:75329
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