2. GPCR/G Protein
  3. Kisspeptin Receptor
  4. Kisspeptin-10, human

Kisspeptin-10, human  (Synonyms: 亲吻促动素-10(人源))

目录号: HY-P0254 纯度: 99.68%
COA 产品使用指南

摩尔计算器

Kisspeptin-10, human 是一种有效的血管收缩剂和血管生成抑制剂。Kisspeptin-10, human 通过其受体 GPR54 来抑制肿瘤转移作用。Kisspeptin-10-GPR54 系统在胚胎肾脏发育中起重要作用。Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达来诱导成骨细胞分化。

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Custom Peptide Synthesis

Kisspeptin-10, human Chemical Structure

Kisspeptin-10, human Chemical Structure

CAS No. : 374675-21-5

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规格 价格 是否有货 数量
1 mg ￥600
In-stock
5 mg ￥1500
In-stock
10 mg ￥2325
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of Kisspeptin-10, human:

Kisspeptin-10, human 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression[1].

IC50 & Target

GPR54[1]
Angiogenesis[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
0.087 nM
Compound: Metastin
Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay
Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay
[PMID: 30598349]
CHO EC50
0.24 nM
Compound: kisspeptin-10
Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay
Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay
[PMID: 19007202]
CHO EC50
0.96 nM
Compound: Metastin(45-54)
Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay
Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay
[PMID: 24918545]
CHO EC50
4.2 nM
Compound: Metastin(45-54)
Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay
Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay
[PMID: 24918545]
CHO IC50
8510 nM
Compound: Metastin(45-54)
Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay
Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay
[PMID: 24047141]
HEK293 EC50
17.3 nM
Compound: 10-mer, metastin-10
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
[PMID: 17266198]
体外研究
(In Vitro)

Kisspeptin-10 (KP-10) and its receptor GPR54 are key components in the regulation of GnRH secretion in humans and other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma and Kisspeptin-10 is a metastasis suppressor in breast cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kisspeptin-10, human 相关抗体:
分子量

1302.44

Formula

C63H83N17O14
CAS 号
性状

固体

颜色

White to off-white

Sequence

Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Sequence Shortening

YNWNSFGLRF-NH2
中文名称

亲吻促动素-10(人源)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 10 mg/mL (7.68 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7678 mL 3.8389 mL 7.6779 mL
5 mM 0.1536 mL 0.7678 mL 1.5356 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.68%

COA (285 KB) LCMS (88 KB)

产品使用指南 (1538 KB)
参考文献

Kisspeptin-10, human 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7678 mL 3.8389 mL 7.6779 mL 19.1947 mL
5 mM 0.1536 mL 0.7678 mL 1.5356 mL 3.8389 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kisspeptin-10, human374675-21-5亲吻促动素-10(人源)Kisspeptin ReceptorKiss1RGPR54Inhibitorinhibitorinhibit

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目录号：
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