2. Gene
  3. STAM - signal transducing adaptor molecule Gene

STAM - signal transducing adaptor molecule Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：信号转导衔接分子

种属: Homo sapiens

同用名: STAM1; STAM-1

基因 ID: 8027 | 基因类型: protein coding

关于 STAM

Cytogenetic location: 10p12.33 Genomic coordinates (GRCh38): 10:17,644,151-17,716,824 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 10 paralogues. Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 7.5) and 25 other tissues.

功能概要

该基因编码信号转导衔接分子家族的一个成员。这些蛋白质介导细胞因子受体的下游信号传导，并且还通过与外壳蛋白 II 复合物相互作用在 ER 到高尔基体的运输中发挥作用。编码的蛋白质还与肝细胞生长因子调节的底物结合，形成 transport-0 (ESCRT-0) 所需的内体分选复合物，它将泛素化的膜蛋白分选到 ESCRT-1 复合物以进行溶酶体降解。已观察到该基因的可变剪接转录物变体。[RefSeq 提供，2011 年 2 月]

This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of Cytokine Receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

STAM 基因产物(9)

mRNA Protein Name
NM_001324282.2 NP_001311211.1 signal transducing adapter molecule 1 isoform e
NM_001324283.2 NP_001311212.1 signal transducing adapter molecule 1 isoform c
NM_001324284.2 NP_001311213.1 signal transducing adapter molecule 1 isoform c
NM_001324285.2 NP_001311214.1 signal transducing adapter molecule 1 isoform c
NM_001324286.2 NP_001311215.1 signal transducing adapter molecule 1 isoform d
NM_001324287.2 NP_001311216.1 signal transducing adapter molecule 1 isoform b
NM_001324288.2 NP_001311217.1 signal transducing adapter molecule 1 isoform f
NM_001324289.2 NP_001311218.1 signal transducing adapter molecule 1 isoform f
NM_003473.4 NP_003464.1 signal transducing adapter molecule 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10383417 GOA
enables ubiquitin-like protein ligase binding IPI
IPI: 通过物理相互作用推断
24790097 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of exosomal secretion IMP
IMP: 通过突变表型推断
24105262 GOA
involved in regulation of extracellular exosome assembly IMP
IMP: 通过突变表型推断
24105262 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ESCRT-0 complex IDA
IDA: 通过直接分析推断
24790097 GOA
part of ESCRT-0 complex IPI
IPI: 通过物理相互作用推断
19278655 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STAM 蛋白结构

VHS

VHS: VHS domain (7 - 139)

UIM

UIM: Ubiquitin interaction motif (171 - 187)

SH3_1

SH3_1: SH3 domain (216 - 261)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 540 a.a.
蛋白主名 其他名称

signal transducing adapter molecule 1

HSE1 homolog

STAM 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STAM Q92783 UBC Homo sapiens P0CG48
NMR
12750381
种属内
STAM Q92783 UBC Homo sapiens P0CG48
X-Ray Diffraction
20150893
种属内
STAM Q92783 LCP2 Homo sapiens Q13094
Peptide Array
17235283
种属内
STAM Q92783 STAMBP Homo sapiens O95630
Y2H
16730941
种属内
STAM Q92783 STAMBP Homo sapiens O95630
ITC
17078930
种属内
STAM Q92783 STAMBP Homo sapiens O95630
Anti Bait CoIP
10383417
种属内
STAM Q92783 STAMBP Homo sapiens O95630
Pull Down
17078930
种属内
STAM Q92783 STAMBP Homo sapiens O95630
Anti Tag CoIP
10383417
种属内
STAM Q92783 HGS Homo sapiens O14964
Anti Tag CoIP
33961781
种属内
STAM Q92783 HGS Homo sapiens O14964
Y2H Pooling
16189514
种属内
STAM Q92783 HGS Homo sapiens O14964
Anti Tag CoIP
35271311
种属间
STAM Q92783 UBB Bos taurus P0CG53
SPR
20150893
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever
Charcot-Marie-Tooth Disease, Demyelinating, Type 1c

Charcot-Marie-Tooth Disease Type 1c

CMT1C

Hmsn1c

Hmsn Ic

Charcot-Marie-Tooth Disease, Type 1c

Charcot-Marie-Tooth Neuropathy Type 1c

Cmt, Slow Nerve Conduction Type C

Charcot-Marie-Tooth Neuropathy, Type 1c

Neuropathy, Hereditary Motor And Sensory, Type Ic

Cmt Slow Nerve Conduction Type C

Neuropathy Hereditary Motor And Sensory Type 1c

Charcot-Marie-Tooth Disease 1c

Charcot-Marie-Tooth Disease Demyelinating Type 1c

Hereditary Motor And Sensory Neuropathy Ic

Charcot-Marie-Tooth Disease, Type Ic
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N6712 Thiolutin Inhibitor 99.24% 否
HY-122883 BC-1471 Inhibitor 99.69% 否
HY-137922 SHS4121705 / 否
HY-RS13869 STAM Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13870 STAM2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta STAM VGNC VGNC:77902
Felis catus STAM VGNC VGNC:65745
Bos taurus STAM VGNC VGNC:35355
Mus musculus STAM MGD MGI:1329014
Canis familiaris STAM VGNC VGNC:46875
Rattus norvegicus STAM RGD RGD:1564499
Others STAM NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z