MAP3K4 - mitogen-activated protein kinase kinase kinase 4 Gene

中文名称：丝裂原活化蛋白激酶激酶激酶 4

种属: Homo sapiens

同用名: MTK1; MEKK4; MEKK 4; MAPKKK4; PRO0412

关于 MAP3K4

功能概要

每个丝裂原活化蛋白激酶 (MAPK) 通路的核心是 3 种蛋白激酶的保守级联：活化的 MAPK 激酶激酶 (MAPKKK) 磷酸化并激活特定的 MAPK 激酶 (MAPKK) ，然后激活特定的 MAPK。 ERK MAPKs 被有丝分裂刺激激活，而 CSBP2 和 JNK MAPKs 被环境压力激活，如渗透压休克、紫外线照射、伤口应激和炎症因子。该基因编码 MAPKKK，即 MEKK4 蛋白，也称为 MTK1。该蛋白质在 C 末端包含一个蛋白激酶催化结构域。 N 端非激酶结构域可能包含一个调节结构域。 MEKK4 在哺乳动物细胞中的表达激活了 CSBP2 和 JNK MAPK 通路，但没有激活 ERK 通路。体外激酶研究表明，重组 MEKK4 可以特异性磷酸化和激活 PRKMK6 和 SERK1，分别激活 CSBP2 和 JNK 的 MAPKK，但不能磷酸化激活 ERK 的 MAPKK PRKMK1。 MEKK4 是激活 CSBP2 MAPK 通路的环境压力的主要介质，也是 JNK 通路的次要介质。已经描述了几种编码不同亚型的可变剪接转录物。[RefSeq 提供，2014 年 5 月]

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]