2. Apoptosis Metabolic Enzyme/Protease
  3. MDM-2/p53 E1/E2/E3 Enzyme
  4. Hdm2 E3 ligase inhibitor 1

Hdm2 E3 ligase inhibitor 1 (Compound 1) 是 Hdm2 (一种 E3 泛素连接酶) 介导的 p53 蛋白泛素化的可逆性抑制剂，IC50 为 12.7 μM。Hdm2 E3 ligase inhibitor 1 可结合 Hdm2，阻断 Hdm2 催化的泛素从预连接的 Ub-Ubc4 转移到 p53，抑制 p53 泛素化，稳定肿瘤细胞中的 p53 蛋白，从而发挥抗肿瘤活性。

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Hdm2 E3 ligase inhibitor 1 Chemical Structure

Hdm2 E3 ligase inhibitor 1 Chemical Structure

CAS No. : 414905-09-2

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生物活性

Hdm2 E3 ligase inhibitor 1 (Compound 1) is a reversible inhibitor for Hdm2 (an E3 ubiquitin ligase)-mediated ubiquitination of the p53 protein with an IC50 of 12.7 μM. Hdm2 E3 ligase inhibitor 1 binds Hdm2, blocks Hdm2-catalyzed ubiquitin transfer from preligated Ub-Ubc4 to p53, inhibits p53 ubiquitination, stabilizes p53 protein in tumor cell and exhibits antitumor efficacy[1].

分子量

350.24

Formula

C10H8F6N2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hdm2 E3 ligase inhibitor 1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Hdm2 E3 ligase inhibitor 1414905-09-2MDM-2/p53E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligasenoncompetitivereversibleubiquitinationInhibitorinhibitorinhibit

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