2. Gene
  3. NBR1 - NBR1 autophagy cargo receptor Gene

NBR1 - NBR1 autophagy cargo receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NBR1 自噬货物受体

种属: Homo sapiens

同用名: IAI3B; M17S2; MIG19; 1A1-3B

基因 ID: 4077 | 基因类型: protein coding

关于 NBR1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,170,409-43,211,688 (from NCBI)

This gene has 7 transcripts (splice variants) and 253 orthologues. Ubiquitous expression in testis (RPKM 41.5), thyroid (RPKM 32.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质最初被鉴定为在卵巢癌中监测的卵巢肿瘤抗原。编码的蛋白质包含一个 B 盒/卷曲螺旋基序，它存在于许多具有转化潜力的基因中。它作为一种特异性自噬受体，通过与泛素化自噬底物形成细胞内包涵体，选择性自噬降解过氧化物酶体。该基因位于染色体 17q21.1 的一个区域，该区域靠近 BRCA1 肿瘤抑制基因。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2014 年 4 月]

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian Cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific Autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

NBR1 基因产物(4)

mRNA Protein Name
NM_001291571.2 NP_001278500.1 next to BRCA1 gene 1 protein isoform b
NM_001291572.2 NP_001278501.1 next to BRCA1 gene 1 protein isoform c
NM_005899.5 NP_005890.2 next to BRCA1 gene 1 protein isoform a
NM_031862.4 NP_114068.1 next to BRCA1 gene 1 protein isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19250911 GOA
enables ubiquitin binding IDA
IDA: 通过直接分析推断
19427866 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in macroautophagy IDA
IDA: 通过直接分析推断
19250911 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
19250911 GOA
colocalizes with mitochondrion IDA
IDA: 通过直接分析推断
21296869 GOA
part of receptor complex IDA
IDA: 通过直接分析推断
19250911 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NBR1 蛋白结构

PB1

PB1: PB1 domain (5 - 84)

ZZ

ZZ: Zinc finger, ZZ type (215 - 245)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 966 a.a.
蛋白主名 其他名称

next to BRCA1 gene 1 protein

B-box protein

NBR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NBR1 Q14596 GSK3A Homo sapiens P49840
Pull Down
20368287
Intra NBR1 Q14596 GSK3A Homo sapiens P49840
BioID
34524948
Intra NBR1 Q14596 MAP1LC3C Homo sapiens Q9BXW4
Pull Down
19250911
Intra NBR1 Q14596 MAP1LC3C Homo sapiens Q9BXW4
Pull Down
20562859
Cross NBR1 Q14596 ATG8 Saccharomyces cerevisiae P38182
Pull Down
19250911
Cross NBR1 Q14596 ATG8 Saccharomyces cerevisiae P38182
Y2H
19250911
Intra NBR1 Q14596 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
19250911
Intra NBR1 Q14596 SQSTM1 Homo sapiens Q13501
Confocal
19250911
Intra NBR1 Q14596 MAP1LC3B Homo sapiens Q9GZQ8
Pull Down
19250911
Intra NBR1 Q14596 MAP1LC3B Homo sapiens Q9GZQ8
Pull Down
20562859
Intra NBR1 Q14596 GABARAP Homo sapiens O95166
Pull Down
19250911
Intra NBR1 Q14596 GABARAP Homo sapiens O95166
Pull Down
20562859
Intra NBR1 Q14596 GABARAPL2 Homo sapiens P60520
Y2H
19250911
Intra NBR1 Q14596 GABARAPL2 Homo sapiens P60520
Pull Down
19250911
Intra NBR1 Q14596 GABARAPL2 Homo sapiens P60520
Pull Down
20562859
Intra NBR1 Q14596 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
Intra NBR1 Q14596 SYT4 Homo sapiens Q9H2B2
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Melioidosis

Melioidosis, Susceptibility To

Acute And Fulminating Melioidosis

Nightcliff Gardener'S Disease

Pseudoglanders

Subacute And Chronic Melioidosis

Burkholderia Pseudomallei Infection

Whitmore Disease

Whitmore'S Disease

B Pseudomallei Infection

Epizootic Lymphangitis

Infection Due To Burkholderia Pseudomallei

Infection Due To Burkholderia Pseudomallei Nos

Infection Due To Malleomyces Pseudomallei

Infection Due To Pseudomonas Pseudomallei

Infection Due To Pseudomonas Pseudomallei Nos

Infection Due To Whitmore Bacillus

Stanton Disease
Myopathy, Myofibrillar, 9, With Early Respiratory Failure

Hereditary Myopathy With Early Respiratory Failure

Hmerf

Myopathy, Proximal, With Early Respiratory Muscle Involvement

Edstrom Myopathy

Mfm-Titinopathy

MFM9

Mprm

Hereditary Inclusion Body Myopathy With Early Respiratory Failure

Hibm-Erf

Myofibrillar Myopathy-Titinopathy

Myofibrillar Myopathy With Early Respiratory Failure

Myopathy, Distal, With Early Respiratory Failure, Autosomal Dominant

Myofibrillar Myopathy 9

Myofibrillar Myopathy 9 With Early Respiratory Failure

Autosomal Dominant Distal Myopathy With Early Respiratory Failure

Proximal Myopathy With Early Respiratory Muscle Involvement

Hereditary Proximal Myopathy With Early Respiratory Failure

Admerf

Edström Myopathy

Hmerf-Erf
Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency

VICIS

Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum

Dionisi Vici Sabetta Gambarara Syndrome

Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum

Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome

Dionisi-Vici-Sabetta-Gambarara Syndrome

Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome

Spiegler-Brooke Syndrome

Familial Cylindromatosis

BRSS

Bss

Sbs

Multiple Familial Trichoepithelioma

Ancell-Spiegler Cylindromas

Familial Multiple Trichoepithelioma

Trichoepithelioma

Fc

Mft

Multiple Familial Trichoepitheliomas

Ccs

Turban Tumor Syndrome

Schilbach-Rott Syndrome

Eccrine Dermal Cylindroma

Familial Multiple Trichoepitheliomata
Paget'S Disease Of Bone

Osteitis Deformans

Paget Disease Of Bone

Osseous Paget'S Disease

Paget Disease Of Bone, Familial

Bone Paget Disease

Familial Paget'S Disease Of Bone

Paget'S Bone Disease

Familial Paget Disease Of Bone

Paget Disease, Bone

Pdb

Pagets Bone Disease
Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders

Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum

Disorders Of Peroxisome Biogenesis

Zellweger Spectrum

Zellweger Syndrome Spectrum

Peroxisomal Biogenesis Disorders

Pbd, Zss

Pbd-Zsd

Pbd-Zss

Pbd-Zellweger Spectrum Disorder

Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum

Peroxisome Biogenesis Disorder

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorders

Zellweger Spectrum Disorder

Hyperpipecolic Acidaemia
Myofibrillar Myopathy

Desmin Related Myopathy

Myotilinopathy

Myopathy, Myofibrillar

Alpha Beta Crystallinopathy

Desmin Storage Myopathy

Desminopathy

Filaminopathy

Protein Surplus Myopathy

Zaspopathy

Myofibrillar Myopathies

Myopathy, Myofibrillar, Desmin-Related

Myopathy, Desmin Storage

Mfm - [Myofibrillar Myopathy]
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder

Infantile Refsum Disease

Infantile Phytanic Acid Storage Disease

PBD1B

Refsum Disease, Infantile

Adrenoleukodystrophy, Autosomal Neonatal

Ird

Mild Pbd-Zsd

Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Pbd-Zsd

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Autosomal Neonatal Adrenoleukodystrophy

Refsum Disease Infantile

Peroxisome Biogenesis Disorders

Peroxisome Biogenesis Disorder, Type 1b
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-146130 ATG7-IN-2 Inhibitor 99.22% 否
HY-146131 ATG7-IN-3 Inhibitor 99.26% 否
HY-RS09061 NBR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NBR1 RGD RGD:69195
Macaca mulatta NBR1 VGNC VGNC:75067
Canis familiaris NBR1 VGNC VGNC:43634
Felis catus NBR1 VGNC VGNC:68118
Mus musculus NBR1 MGD MGI:108498
Bos taurus NBR1 VGNC VGNC:31896
Others NBR1 NCBI
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