GSK3A - glycogen synthase kinase 3 alpha Gene

中文名称：糖原合酶激酶 3 α

种属: Homo sapiens

基因 ID: 2931 | 基因类型: protein coding

关于 GSK3A

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,230,190-42,242,602 (from NCBI)

This gene has 40 transcripts (splice variants), 260 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 26.3), testis (RPKM 18.3) and 25 other tissues.

功能概要

该基因编码一种多功能 Ser/Thr 蛋白激酶，该激酶参与控制多种调节蛋白，包括糖原合酶和转录因子，如 JUN。它还在 Wnt 和 PI3K 信号通路中发挥作用，并调节与阿尔茨海默病相关的 β-淀粉样肽的产生。[RefSeq 提供，2011 年 10 月]

This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the Wnt and PI3K signaling pathways, as well as regulates the production of beta-amyloid Peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]

GSK3A 基因产物(2)

mRNA	Protein	Name
NM_019884.3	NP_063937.2	glycogen synthase kinase-3 alpha
XR_001753673.2

GSK3A 蛋白结构

Pkinase

0
100
200
300
400
483 a.a.

蛋白主名

其他名称

glycogen synthase kinase-3 alpha

GSK-3 alpha

serine/threonine-protein kinase GSK3A

GSK3A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GSK3A	P49840	GSKIP	Homo sapiens	Q9P0R6	Anti Tag CoIP	35271311
种属内	GSK3A	P49840	GSKIP	Homo sapiens	Q9P0R6	TAP	23602568
种属内	GSK3A	P49840	FBXO42	Homo sapiens	Q6P3S6	Y2H	30824926
种属内	GSK3A	P49840	HSP90AB1	Homo sapiens	P08238	Y2H	30824926
种属内	GSK3A	P49840	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	GSK3A	P49840	MAPT	Homo sapiens	P10636-8	Protein Kinase Assay	26618561
种属内	GSK3A	P49840	FRAT1	Homo sapiens	Q92837	Anti Tag CoIP	33961781
种属内	GSK3A	P49840	FRAT1	Homo sapiens	Q92837	TAP	23602568
种属内	GSK3A	P49840	AXIN2	Homo sapiens	Q9Y2T1	TAP	23602568
种属内	GSK3A	P49840	AXIN2	Homo sapiens	Q9Y2T1	Y2H	30824926
种属内	GSK3A	P49840	AXIN2	Homo sapiens	Q9Y2T1	Anti Tag CoIP	33961781
种属内	GSK3A	P49840	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
种属内	GSK3A	P49840	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
种属内	GSK3A	P49840	AXIN1	Homo sapiens	O15169	Anti Tag CoIP	33961781
种属内	GSK3A	P49840	AXIN1	Homo sapiens	O15169	TAP	23602568
种属内	GSK3A	P49840	AXIN1	Homo sapiens	O15169	Anti Tag CoIP	17318175
种属内	GSK3A	P49840	AXIN1	Homo sapiens	O15169	Anti Tag CoIP	35271311
种属内	GSK3A	P49840	DEAF1	Homo sapiens	O75398	Y2H	30824926
种属内	GSK3A	P49840	DEAF1	Homo sapiens	O75398	Protein Kinase Assay	20368287
种属内	GSK3A	P49840	NBR1	Homo sapiens	Q14596	Anti Tag CoIP	33961781
种属内	GSK3A	P49840	NBR1	Homo sapiens	Q14596	Pull Down	24879152
种属内	GSK3A	P49840	NBR1	Homo sapiens	Q14596	Y2H	30824926
种属内	GSK3A	P49840	NBR1	Homo sapiens	Q14596	Protein Kinase Assay	24879152
种属内	GSK3A	P49840	LRP6	Homo sapiens	O75581	Y2H	30824926
种属内	GSK3A	P49840	LRP6	Homo sapiens	O75581	Pull Down	16365045
种属内	GSK3A	P49840	LRP6	Homo sapiens	O75581	Anti Tag CoIP	16365045

种属间: 跨种属相互作用 种属内: 同种属相互作用

GSK3A 抗体

目录号	产品名	应用	反应物种
HY-P80819	Phospho-GSK3 (Tyr216/Tyr279) Antibody	WB, IP	Mouse, Rat
HY-P82117	GSK3 alpha/beta Antibody (YA1862)	WB	Human, Rat, Hamster
HY-P83226	GSK3 alpha Antibody (YA2971)	WB, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-136848	SM1-71	Inhibitor	96.09%	否
HY-122665	HTH-01-091	Inhibitor	98.64%	否
HY-122665A	HTH-01-091 TFA	Inhibitor	99.48%	否
HY-RS05862	GSK3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS05863	Gsk3a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS05864	Gsk3a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W969907	GSK3-IN-7		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	GSK3A	RGD	RGD:620351
Mus musculus	GSK3A	MGD	MGI:2152453
Canis familiaris	GSK3A	VGNC	VGNC:101443
Bos taurus	GSK3A	VGNC	VGNC:101449
Felis catus	GSK3A	VGNC	VGNC:101459
Others	GSK3A	NCBI

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