1. Gene
  2. FBXO42 - F-box protein 42 Gene

FBXO42 - F-box protein 42 Gene

中文名称:F-box 蛋白 42

种属: Homo sapiens

同用名: JFK; Fbx42

基因 ID: 54455 | 基因类型: protein coding

关于 FBXO42

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,246,840-16,352,480 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 10 paralogues. Ubiquitous expression in skin (RPKM 6.4), fat (RPKM 5.1) and 25 other tissues.

功能概要

F-box 蛋白家族的成员,例如 FBXO42,以大约 40 个氨基酸的 F-box 基序为特征。由 SKP1 (SKP1A;MIM 601434) 、cullin (参见 CUL1;MIM 603134) 和 F-box 蛋白形成的 SCF 复合物充当蛋白质-泛素连接酶。 F-box 蛋白通过 F-box 与 SKP1 相互作用,并通过其他蛋白质相互作用域与泛素化靶标相互作用 (Jin 等人,2004 [PubMed 15520277]) 。[OMIM 提供,2010 年 12 月]

Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]

FBXO42 基因产物(1)

mRNA Protein Name
NM_018994.3 NP_061867.1 F-box only protein 42
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25609649 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FBXO42 蛋白结构

F-box-like

F-box-like: F-box-like (48 - 82)

Kelch_3

Kelch_3: Galactose oxidase, central domain (131 - 182)

Kelch_2

Kelch_2: Kelch motif (231 - 274)

  • 0
  • 200
  • 400
  • 600
  • 717 a.a.
蛋白主名 其他名称

F-box only protein 42

just one F-box and Kelch domain-containing protein

FBXO42 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FBXO42 Q6P3S6 GSK3A Homo sapiens P49840
Anti Tag CoIP
33961781
种属内
FBXO42 Q6P3S6 GSK3A Homo sapiens P49840
Anti Tag CoIP
28514442
种属内
FBXO42 Q6P3S6 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
种属内
FBXO42 Q6P3S6 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
种属内
FBXO42 Q6P3S6 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
种属内
FBXO42 Q6P3S6 TPP1 Homo sapiens O14773
Validated Y2H
32814053
种属内
FBXO42 Q6P3S6 TPP1 Homo sapiens O14773
Y2H Array
32814053
种属内
FBXO42 Q6P3S6 TPP1 Homo sapiens O14773
Y2H Pooling
32814053
种属内
FBXO42 Q6P3S6 RBPJ Homo sapiens Q06330
Anti Tag CoIP
33961781
种属内
FBXO42 Q6P3S6 RBPJ Homo sapiens Q06330
TAP
25609649
种属内
FBXO42 Q6P3S6 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
FBXO42 Q6P3S6 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
FBXO42 Q6P3S6 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
FBXO42 Q6P3S6 NDUFV1 Homo sapiens P49821
Validated Y2H
32814053
种属内
FBXO42 Q6P3S6 NDUFV1 Homo sapiens P49821
Y2H Pooling
32814053
种属内
FBXO42 Q6P3S6 NDUFV1 Homo sapiens P49821
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Desmoid Disease, Hereditary

Fif

DESMD

Hereditary Desmoid Disease

Familial Infiltrative Fibromatosis

Fibromatosis, Familial Infiltrative

Fibromatosis, Aggressive

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome

Pallidopyramidal Syndrome

Parkinson Disease 15, Autosomal Recessive

PARK15

Pkps

Pallido-Pyramidal Syndrome

Parkinson'S Disease 15

Autosomal Recessive Early-Onset Parkinson Disease 15

Autosomal Recessive Early-Onset Parkinson'S Disease 15

Pallido-Pyramidal Disease

Parkinson Disease 15

Parkinson Disease 15 Autosomal Recessive

Pps

Parkinson Disease, Type 15

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FBXO42 RGD RGD:1304787
Macaca mulatta FBXO42 VGNC VGNC:72597
Mus musculus FBXO42 MGD MGI:1924992
Bos taurus FBXO42 VGNC VGNC:28913
Felis catus FBXO42 VGNC VGNC:62194
Canis familiaris FBXO42 VGNC VGNC:40782