GSKIP - GSK3B interacting protein Gene

中文名称：GSK3B 相互作用蛋白

种属: Homo sapiens

同用名: HSPC210; C14orf129

关于 GSKIP

功能概要

该基因编码一种蛋白质，该蛋白质在 Wnt 信号通路中作为 GSK3-beta 的负调节因子参与。编码的蛋白质可能通过调节 GSK3-β、β-连环蛋白和细胞周期蛋白 D1 之间的功能性相互作用在视黄酸信号通路中发挥作用，并调节β-连环蛋白/N-钙粘蛋白池。编码的蛋白质在其 C 末端包含一个 GSK3-beta 相互作用结构域 (GID) ，这与 Axin 的 GID 相似。该蛋白还包含一个进化上保守的 RII 结合域，该域有助于与蛋白激酶 A 和 GSK3-beta 结合，从而使其发挥 A 激酶锚定蛋白的作用。已观察到该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 12 月]

This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-Cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]