2. Gene
  3. FRAT1 - FRAT regulator of WNT signaling pathway 1 Gene

FRAT1 - FRAT regulator of WNT signaling pathway 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：WNT 信号通路 1 的 FRAT 调节器

种属: Homo sapiens

基因 ID: 10023 | 基因类型: protein coding

关于 FRAT1

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:97,319,271-97,321,915 (from NCBI)

This gene has 2 transcripts (splice variants), 63 orthologues and 1 paralogue.

功能概要

该基因编码的蛋白质属于 GSK-3 结合蛋白家族。该蛋白抑制 GSK-3 介导的 β-连环蛋白磷酸化并正向调节 Wnt 信号通路。它可能在肿瘤进展和淋巴瘤形成中发挥作用。[RefSeq 提供，2008 年 10 月]

The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]

FRAT1 基因产物(1)

mRNA Protein Name
NM_005479.4 NP_005470.2 proto-oncogene FRAT1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular function inhibitor activity IDA
IDA: 通过直接分析推断
10481074 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10481074 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
10428961 GOA
involved in canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
12556519 GOA
involved in positive regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
12556519 GOA
involved in regulation of protein export from nucleus IDA
IDA: 通过直接分析推断
12223487 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12223487 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12223487 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FRAT1 蛋白结构

GSK-3_bind

GSK-3_bind: Glycogen synthase kinase-3 binding (1 - 239)

  • 0
  • 100
  • 200
  • 279 a.a.
蛋白主名 其他名称

proto-oncogene FRAT1

FRAT-1

FRAT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FRAT1 Q92837 GSK3A Homo sapiens P49840
Pull Down
10481074
种属内
FRAT1 Q92837 GSK3A Homo sapiens P49840
Anti Tag CoIP
26496610
种属内
FRAT1 Q92837 GSK3B Homo sapiens P49841
X-Ray Diffraction
11738041
种属内
FRAT1 Q92837 GSK3B Homo sapiens P49841
Anti Tag CoIP
26496610
种属间: 跨种属相互作用 种属内: 同种属相互作用

FRAT1 抗体

目录号 产品名 应用 反应物种
HY-P83118 FRAT1 Antibody (YA2863) WB, ICC/IF, IP Human

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05090 FRAT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FRAT1 VGNC VGNC:72816
Mus musculus FRAT1 MGD MGI:109450
Bos taurus FRAT1 VGNC VGNC:55951
Rattus norvegicus FRAT1 RGD RGD:9147096
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