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  2. SYT4 - synaptotagmin 4 Gene

SYT4 - synaptotagmin 4 Gene

中文名称:突触结合蛋白 4

种属: Homo sapiens

同用名: HsT1192

基因 ID: 6860 | 基因类型: protein coding

关于 SYT4

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:43,267,892-43,277,490 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 31 paralogues. Biased expression in brain (RPKM 34.8), adrenal (RPKM 10.3) and 1 other tissue.

功能概要

预计具有多种功能,包括钙离子结合活性;磷脂结合活性;和突触融合蛋白结合活性。参与儿茶酚胺分泌的负调节和树突延伸的正调节。预计位于多种细胞成分中,包括微泡;细胞质的核周区;和分泌囊泡。预计在几种细胞成分中具有活性,包括轴突;胞吐囊泡;和谷氨酸能突触。预计是神经元致密核心囊泡膜的组成部分。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in negative regulation of Catecholamine secretion and positive regulation of dendrite extension. Predicted to be located in several cellular components, including microvesicle; perinuclear region of cytoplasm; and secretory vesicle. Predicted to be active in several cellular components, including axon; exocytic vesicle; and glutamatergic synapse. Predicted to be integral component of neuronal dense core vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]

SYT4 基因产物(1)

mRNA Protein Name
NM_020783.4 NP_065834.1 synaptotagmin-4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of catecholamine secretion IGI
IGI: 通过遗传相互作用推断
20735850 GOA
involved in positive regulation of dendrite extension IDA
IDA: 通过直接分析推断
23999003 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SYT4 蛋白结构

C2

C2: C2 domain (171 - 257)

C2

C2: C2 domain (304 - 391)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 425 a.a.
蛋白主名 其他名称

synaptotagmin-4

synaptotagmin IV

SYT4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SYT4 Q9H2B2 NBR1 Homo sapiens Q14596-2
Y2H Prey Pooling
32296183
种属内
SYT4 Q9H2B2 NBR1 Homo sapiens Q14596-2
Y2H Array
32296183
种属内
SYT4 Q9H2B2 NDUFA12 Homo sapiens Q9UI09
Validated Y2H
32296183
种属内
SYT4 Q9H2B2 NDUFA12 Homo sapiens Q9UI09
Y2H Array
32296183
种属内
SYT4 Q9H2B2 NDUFA12 Homo sapiens Q9UI09
Y2H Prey Pooling
32296183
种属内
SYT4 Q9H2B2 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
种属内
SYT4 Q9H2B2 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
种属内
SYT4 Q9H2B2 SGTA Homo sapiens O43765
Y2H Array
32296183
种属内
SYT4 Q9H2B2 NBR1 Homo sapiens Q14596
Y2H Array
25416956
种属内
SYT4 Q9H2B2 NBR1 Homo sapiens Q14596
Validated Y2H
25416956
种属内
SYT4 Q9H2B2 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
种属内
SYT4 Q9H2B2 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2

Pontocerebellar Hypoplasia Type 2e

Pch2

PCH2E

Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy

Pontocerebellar Hypoplasia 2e

Pcca2

Progressive Cerebello-Cerebral Atrophy Type 2

Doid:0112328

Hypoplasia, Pontocerebellar, Type 2e

Pontocerebellar Hypoplasia, Type 2d

Pontocerebellar Hypoplasia Type 2a

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SYT4 VGNC VGNC:78076
Felis catus SYT4 VGNC VGNC:80495
Rattus norvegicus SYT4 RGD RGD:68397
Canis familiaris SYT4 VGNC VGNC:47047
Bos taurus SYT4 VGNC VGNC:35543
Mus musculus SYT4 MGD MGI:101759