TLE1 - TLE family member 1, transcriptional corepressor Gene

中文名称：TLE 家族成员 1，转录辅阻遏物

种属: Homo sapiens

同用名: ESG; ESG1; GRG1; TLE-1

基因 ID: 7088 | 基因类型: protein coding

关于 TLE1

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:81,583,683-81,689,547 (from NCBI)

This gene has 7 transcripts (splice variants), 262 orthologues and 6 paralogues. Ubiquitous expression in fat (RPKM 15.1), endometrium (RPKM 10.2) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性和转录辅阻遏物活性。参与 I-kappaB 激酶/NF-kappaB 信号的负调控；失巢凋亡的负调节；和基因表达的调控。位于细胞质和核质中。 β-连环蛋白-TCF 复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]

TLE1 基因产物(3)

mRNA	Protein	Name
NM_001303103.2	NP_001290032.1	transducin-like enhancer protein 1 isoform 1
NM_001303104.2	NP_001290033.1	transducin-like enhancer protein 1 isoform 3
NM_005077.5	NP_005068.2	transducin-like enhancer protein 1 isoform 2

TLE1 蛋白结构

TLE_N

WD40

0
200
400
600
770 a.a.

蛋白主名

其他名称

transducin-like enhancer protein 1

enhancer of split groucho-like protein 1

TLE1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TLE1	Q04724	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	17680780
Intra	TLE1	Q04724	H4C16	Homo sapiens	P62805	Far-WB	24596249
Intra	TLE1	Q04724	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	TLE1	Q04724	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	TLE1	Q04724	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	TLE1	Q04724	SYT-SSX2	Homo sapiens	A4PIW0	Anti Bait CoIP	22439931
Intra	TLE1	Q04724	SYT-SSX2	Homo sapiens	A4PIW0	Anti Tag CoIP	22439931
Intra	TLE1	Q04724	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	TLE1	Q04724	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
Intra	TLE1	Q04724	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	TLE1	Q04724	DAZAP2	Homo sapiens	Q15038	Y2H Array	20211142
Intra	TLE1	Q04724	TLE1	Homo sapiens	Q04724	X-Ray Diffraction	24596249
Intra	TLE1	Q04724	RUNX1	Homo sapiens	Q01196-1	Beta Galactosidase	9751710
Intra	TLE1	Q04724	TLE1	Homo sapiens	Q04724	SAXS	24596249
Intra	TLE1	Q04724	RUNX1	Homo sapiens	Q01196-1	Pull Down	9751710
Intra	TLE1	Q04724	RUNX3	Homo sapiens	Q13761	Beta Galactosidase	9751710
Intra	TLE1	Q04724	TLE1	Homo sapiens	Q04724	GMS	24596249
Intra	TLE1	Q04724	FOXG1	Homo sapiens	P55316	Anti Bait CoIP	24356439
Intra	TLE1	Q04724	NOD2	Homo sapiens	Q9HC29	Anti Bait CoIP	21699783
Intra	TLE1	Q04724	NOD2	Homo sapiens	Q9HC29	Y2H	21699783
Intra	TLE1	Q04724	HES6	Homo sapiens	Q96HZ4	Y2H Array	20211142

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Glomus Tumor

Glomus Neoplasm

Glomus Tumour

Thymus Sarcomatoid Carcinoma

Thymic Carcinosarcoma

Thymic Sarcomatoid Carcinoma

Monophasic Synovial Sarcoma

Monophasic Sarcoma Of Synovium

Biphasic Synovial Sarcoma

Synovial Sarcoma, Biphasic

Biphasic Sarcoma Of Synovium

Malignant Glandular Tumor Of Peripheral Nerve Sheath

Glandular Mpnst

Glandular Malignant Peripheral Nerve Sheath Tumor

Tibial Adamantinoma

Tibial Adamantinoma Morphology

Adamantinoma Of Long Bones

Long Bone Adamantinoma

Spindle Cell Synovial Sarcoma

Synovial Sarcoma With Spindle Cell Components	Synovial Sarcoma, Monophasic Fibrous
Synovial Sarcoma, Spindle Cell

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Cellular Neurofibroma

Cellular Schwannoma

Cellular Neurinoma

Kidney Sarcoma

Renal Sarcoma

Sarcoma Of Kidney

Malignant Triton Tumor

Malignant Peripheral Nerve Sheath Neoplasm With Rhabdomyosarcoma	Malignant Triton Tumour
Mpnst With Rhabdomyoblastic Differentiation	Mpnst With Rhabdomyosarcoma
Mpnst With Rhabdomyosarcomatous Differentiation	Mtt
Malignant Peripheral Nerve Sheath Tumor With Rhabdomyosarcomatous Differenciation	Malignant Peripheral Nerve Sheath Tumor With Rhabdomyoblastic Differentiation

Conventional Leiomyosarcoma

Spindle Cell Thymoma

Medullary Thymoma	Thymoma, Medullary
Thymoma, Type A

Synovium Neoplasm

Synovial Neoplasm

Tumor Of Synovium

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Epithelioid Malignant Peripheral Nerve Sheath Tumor

Epithelioid Mpnst

Malignant Epithelioid Neoplasm Of The Peripheral Nerve Sheath

Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney	Childhood Kidney Clear Cell Sarcoma
Renal Clear Cell Sarcoma	Ccsk
Clear Cell Sarcoma Of The Kidney

Subungual Glomus Tumor

Subungual Glomus Tumour

Spindle Cell Sarcoma

Sarcoma	Sarcoma Spindle Cell
Sarcoma, Spindle Cell	Sarcoma - Category

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Sarcomatoid Mesothelioma

Malignant Fibrous Mesothelioma

Spindled Mesothelioma

Malignant Spindle Cell Melanoma

Spindle Cell Melanoma	Desmoplastic Melanoma
Spindle Cell Malignant Melanoma	Spitzoid Malignant Melanoma

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Dermatofibrosarcoma Protuberans

DFSP	Dermatofibrosarcoma
Giant Cell Fibroblastoma	Metastatic Dermatofibrosarcoma Protuberans
Familial Dermatofibrosarcoma Protuberans	Darier-Ferrand Tumor
Darier-Hoffmann Tumor

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor	Atypical Lipoma
Alt	Wdls
Liposarcoma, Well Differentiated	Pleomorphic Lipoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Dedifferentiated Liposarcoma

Ddls	Liposarcoma Dedifferentiated
Liposarcoma, Dedifferentiated

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14563	TLE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-P10488	cycFWRPW	Activator	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TLE1	VGNC	VGNC:66208
Mus musculus	TLE1	MGD	MGI:104636
Canis familiaris	TLE1	VGNC	VGNC:47396
Macaca mulatta	TLE1	VGNC	VGNC:78364
Rattus norvegicus	TLE1	RGD	RGD:1309237

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TLE1 - TLE family member 1, transcriptional corepressor Gene

关于 TLE1

功能概要

TLE1 基因产物(3)

TLE1 蛋白结构

TLE1 蛋白互作信息

关联疾病

直系同源

热门区域

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TLE1 - TLE family member 1, transcriptional corepressor Gene

关于 TLE1

功能概要

TLE1 基因产物(3)

TLE1 蛋白结构

TLE1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z