2. Gene
  3. HES6 - hes family bHLH transcription factor 6 Gene

HES6 - hes family bHLH transcription factor 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：hes 家族 bHLH 转录因子 6

种属: Homo sapiens

同用名: HES-6; bHLHb41; bHLHc23; C-HAIRY1

基因 ID: 55502 | 基因类型: protein coding

关于 HES6

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:238,238,267-238,240,038 (from NCBI)

This gene has 9 transcripts (splice variants), 260 orthologues and 12 paralogues. Biased expression in brain (RPKM 23.5), colon (RPKM 8.2) and 12 other tissues.

功能概要

该基因编码基本螺旋-环-螺旋转录抑制因子亚家族的成员，该抑制因子与分裂基因的果蝇增强子具有同源性。该基因家族的成员调节多种细胞类型的细胞分化。由该基因编码的蛋白质起辅助因子的作用，通过其 C 末端的四肽结构域与其他转录因子相互作用。已经描述了编码不同亚型的选择性剪接转录变体。[RefSeq 提供，2008 年 12 月]

This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

HES6 基因产物(3)

mRNA Protein Name
NM_001142853.3 NP_001136325.1 transcription cofactor HES-6 isoform b
NM_001282434.2 NP_001269363.1 transcription cofactor HES-6 isoform c
NM_018645.6 NP_061115.2 transcription cofactor HES-6 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20211142 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HES6 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (26 - 73)

Hairy_orange

Hairy_orange: Hairy Orange (94 - 134)

  • 0
  • 100
  • 200
  • 224 a.a.
蛋白主名 其他名称

transcription cofactor HES-6

class B basic helix-loop-helix protein 41

HES6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HES6 Q96HZ4 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra HES6 Q96HZ4 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra HES6 Q96HZ4 TLE1 Homo sapiens Q04724
Anti Tag CoIP
33961781
Intra HES6 Q96HZ4 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra HES6 Q96HZ4 RAB2A Homo sapiens P61019
Y2H Array
32296183
Intra HES6 Q96HZ4 RAB2A Homo sapiens P61019
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06139 HES6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta HES6 VGNC VGNC:99366
Felis catus HES6 VGNC VGNC:80228
Canis familiaris HES6 VGNC VGNC:59081
Rattus norvegicus HES6 RGD RGD:1312047
Bos taurus HES6 VGNC VGNC:29823
Mus musculus HES6 MGD MGI:1859852
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