2. Gene
  3. RAB2A - RAB2A, member RAS oncogene family Gene

RAB2A - RAB2A, member RAS oncogene family Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAB2A，成员 RAS 致癌基因家族

种属: Homo sapiens

同用名: LHX; RAB2

基因 ID: 5862 | 基因类型: protein coding

关于 RAB2A

Cytogenetic location: 8q12.1-q12.2 Genomic coordinates (GRCh38): 8:60,516,910-60,623,644 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 68 paralogues. Ubiquitous expression in brain (RPKM 44.0), thyroid (RPKM 43.9) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 Rab 家族，其成员是小分子量鸟苷三磷酸酶 (GTPases) ，其中包含参与 GTP 结合和水解的高度保守结构域。 Rab 是膜结合蛋白，参与囊泡融合和运输。这种蛋白质是前高尔基中间体的居民，是蛋白质从内质网 (ER) 到高尔基复合体的运输所必需的。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

RAB2A 基因产物(2)

mRNA Protein Name
NM_001242644.1 NP_001229573.1 ras-related protein Rab-2A isoform b
NM_002865.3 NP_002856.1 ras-related protein Rab-2A isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GDP binding IDA
IDA: 通过直接分析推断
16034420 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
16034420 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
16034420 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi organization IMP
IMP: 通过突变表型推断
17684057 GOA
NOT involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: 通过突变表型推断
17684057 GOA
involved in macroautophagy IMP
IMP: 通过突变表型推断
28483915 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAB2A 蛋白结构

Ras

Ras: Ras family (8 - 168)

  • 0
  • 100
  • 200
  • 212 a.a.
蛋白主名 其他名称

ras-related protein Rab-2A

RAB2, member RAS oncogene family

RAB2A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RAB2A P61019 ICA1 Homo sapiens Q05084
Y2H Array
25416956
Intra RAB2A P61019 ICA1 Homo sapiens Q05084
Y2H Array
29892012
Intra RAB2A P61019 ICA1 Homo sapiens Q05084
Y2H Prey Pooling
25416956
Intra RAB2A P61019 FAM114A2 Homo sapiens Q9NRY5
Validated Y2H
32296183
Intra RAB2A P61019 FAM114A2 Homo sapiens Q9NRY5
Y2H Prey Pooling
32296183
Intra RAB2A P61019 FAM114A2 Homo sapiens Q9NRY5
Y2H Array
32296183
Intra RAB2A P61019 FRMD1 Homo sapiens Q8N878
Validated Y2H
32296183
Intra RAB2A P61019 TBC1D25 Homo sapiens Q3MII6
Y2H Prey Pooling
32296183
Intra RAB2A P61019 TBC1D25 Homo sapiens Q3MII6
Y2H Array
32296183
Intra RAB2A P61019 TBC1D25 Homo sapiens Q3MII6
Validated Y2H
32296183
Intra RAB2A P61019 CCDC125 Homo sapiens Q86Z20
Validated Y2H
32296183
Intra RAB2A P61019 CCDC125 Homo sapiens Q86Z20
Y2H Array
32296183
Intra RAB2A P61019 CCDC125 Homo sapiens Q86Z20
Y2H Prey Pooling
32296183
Intra RAB2A P61019 PMAIP1 Homo sapiens Q13794-2
Validated Y2H
32296183
Intra RAB2A P61019 GARIN1A Homo sapiens Q6NXP2-2
Y2H Prey Pooling
32296183
Intra RAB2A P61019 GARIN1A Homo sapiens Q6NXP2-2
Y2H Array
32296183
Intra RAB2A P61019 GARIN1A Homo sapiens Q6NXP2-2
Validated Y2H
32296183
Intra RAB2A P61019 GARIN4 Homo sapiens Q8IYT1
Y2H Prey Pooling
32296183
Intra RAB2A P61019 GARIN4 Homo sapiens Q8IYT1
Validated Y2H
32296183
Intra RAB2A P61019 GARIN4 Homo sapiens Q8IYT1
Y2H Array
32296183
Intra RAB2A P61019 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra RAB2A P61019 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra RAB2A P61019 BLZF1 Homo sapiens Q9H2G9
Y2H Array
31515488
Intra RAB2A P61019 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra RAB2A P61019 FAM114A1 Homo sapiens Q8IWE2
Y2H Array
31515488
Intra RAB2A P61019 FAM114A1 Homo sapiens Q8IWE2
Validated Y2H
25416956
Intra RAB2A P61019 FAM114A1 Homo sapiens Q8IWE2
Y2H Prey Pooling
32296183
Intra RAB2A P61019 FAM114A1 Homo sapiens Q8IWE2
Y2H Prey Pooling
25416956
Intra RAB2A P61019 FAM114A1 Homo sapiens Q8IWE2
Validated Y2H
32296183
Intra RAB2A P61019 FAM114A1 Homo sapiens Q8IWE2
Y2H Array
25416956
Intra RAB2A P61019 FAM114A1 Homo sapiens Q8IWE2
Y2H Array
32296183
Intra RAB2A P61019 TRIM7 Homo sapiens Q9C029
Validated Y2H
32296183
Intra RAB2A P61019 TRIM7 Homo sapiens Q9C029
Y2H Prey Pooling
32296183
Intra RAB2A P61019 TRIM7 Homo sapiens Q9C029
Y2H Array
32296183
Intra RAB2A P61019 CFL2 Homo sapiens Q9Y281
Validated Y2H
32296183
Intra RAB2A P61019 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra RAB2A P61019 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra RAB2A P61019 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra RAB2A P61019 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra RAB2A P61019 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra RAB2A P61019 TMEM70 Homo sapiens Q9BUB7
Validated Y2H
32296183
Intra RAB2A P61019 STAMBPL1 Homo sapiens Q96FJ0
Y2H Prey Pooling
25416956
Intra RAB2A P61019 STAMBPL1 Homo sapiens Q96FJ0
Y2H Prey Pooling
32296183
Intra RAB2A P61019 STAMBPL1 Homo sapiens Q96FJ0
Validated Y2H
32296183
Intra RAB2A P61019 STAMBPL1 Homo sapiens Q96FJ0
Y2H Array
32296183
Intra RAB2A P61019 STAMBPL1 Homo sapiens Q96FJ0
Y2H
21516116
Intra RAB2A P61019 HES6 Homo sapiens Q96HZ4
Validated Y2H
32296183
Intra RAB2A P61019 GARIN6 Homo sapiens Q8NEG0
Validated Y2H
32296183
Intra RAB2A P61019 GARIN6 Homo sapiens Q8NEG0
Y2H Array
32296183
Intra RAB2A P61019 GARIN6 Homo sapiens Q8NEG0
Y2H Pooling
16189514
Intra RAB2A P61019 GARIN6 Homo sapiens Q8NEG0
Y2H Prey Pooling
25416956
Intra RAB2A P61019 GARIN6 Homo sapiens Q8NEG0
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Warburg Micro Syndrome 1

Warburg Micro Syndrome

Micro Syndrome

Warbm

WARBM1

Warburg Sjo Fledelius Syndrome

Warburg-Sjo-Fledelius Syndrome

Micro Syndrome 1

Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Lipoblastoma
Sezary'S Disease

Sezary Syndrome

Sézary Syndrome

Sezary'S Lymphoma

Sezary Disease

Sezary Erythroderma

Sezary Lymphoma
Chronic Salpingo-Oophoritis

Chronic Salpingitis And Oophoritis

Chronic Salpingitis/Oophoritis
Warburg Micro Syndrome 3

WARBM3

Micro Syndrome 3
Warburg Micro Syndrome 2

WARBM2

Micro Syndrome 2
Smith-Mccort Dysplasia 1

Smith-Mccort Dysplasia

SMC1

Smc

Smith Mccort Dysplasia

Smith-Mccort Dwarfism
Warburg Micro Syndrome 4

WARBM4

Micro Syndrome 4
Salpingo-Oophoritis

Tubo-Ovarian Inflammatory Disease

Salpingitis/Oophoritis

Suppurative Salpingo Oophoritis

Tubo-Ovarian Inflammation

Tubo-Ovarian Inflammatory Disorder

Purulent Salpingo Oophoritis

Septic Salpingo Oophoritis

Salpingo-Ovaritis

Inflammation Oviduct

Ruptured Salpingo Oophoritis

Pyosalpinx Rupture
Dyggve-Melchior-Clausen Disease

Dyggve-Melchior-Clausen Syndrome

DMC

Dmc Disease

Pseudo-Morquio Disease Type I

Dmc Syndrome
Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome

Duane'S Syndrome

Duane Syndrome

Isolated Duane Retraction Syndrome

Co-Contractive Retraction Syndrome

Duane Anomaly, Isolated

Ocular Retraction Syndrome

Drs

Durs
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-124306 ML-099 Activator 99.75% 否
HY-RS11541 RAB2A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus RAB2A VGNC VGNC:33637
Canis familiaris RAB2A VGNC VGNC:45271
Macaca mulatta RAB2A VGNC VGNC:81529
Felis catus RAB2A VGNC VGNC:97587
Mus musculus RAB2A MGD MGI:1928750
Rattus norvegicus RAB2A RGD RGD:68323
Others RAB2A NCBI
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