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  2. CELF5 - CUGBP Elav-like family member 5 Gene

CELF5 - CUGBP Elav-like family member 5 Gene

中文名称:CUGBP 类 Elav 家族成员 5

种属: Homo sapiens

同用名: CELF-5; BRUNOL5; BRUNOL-5

基因 ID: 60680 | 基因类型: protein coding

关于 CELF5

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,224,661-3,297,076 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues and 6 paralogues. Biased expression in brain (RPKM 14.1), ovary (RPKM 2.1) and 1 other tissue.

功能概要

该基因编码 CELF/BRUNOL 蛋白家族的一员,该家族包含两个 N 端 RNA 识别基序 (RRM) 结构域、一个 C 端 RRM 结构域,以及第二个和第三个 RRM 之间的 160-230 aa 的不同片段域。该蛋白家族的成员调节 pre-mRNA 可变剪接,也可能参与 mRNA 编辑和翻译。已发现该基因的可变剪接转录物变体。[RefSeq 提供,2012 年 1 月]

This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing and translation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

CELF5 基因产物(2)

mRNA Protein Name
NM_001172673.2 NP_001166144.1 CUGBP Elav-like family member 5 isoform 2
NM_021938.4 NP_068757.2 CUGBP Elav-like family member 5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
11158314 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CELF5 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (47 - 113)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (136 - 198)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (402 - 471)

  • 0
  • 100
  • 200
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  • 400
  • 485 a.a.
蛋白主名 其他名称

CUGBP Elav-like family member 5

CUG-BP and ETR-3 like factor 5

CELF5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CELF5 Q8N6W0 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
32296183
种属内
CELF5 Q8N6W0 VASN Homo sapiens Q6EMK4
Y2H Array
32296183
种属内
CELF5 Q8N6W0 VASN Homo sapiens Q6EMK4
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
种属内
CELF5 Q8N6W0 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
种属内
CELF5 Q8N6W0 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
种属内
CELF5 Q8N6W0 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
种属内
CELF5 Q8N6W0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
种属内
CELF5 Q8N6W0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
种属内
CELF5 Q8N6W0 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
种属内
CELF5 Q8N6W0 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
种属内
CELF5 Q8N6W0 PRR13 Homo sapiens Q9NZ81
Y2H Array
32296183
种属内
CELF5 Q8N6W0 PRR13 Homo sapiens Q9NZ81
Validated Y2H
32296183
种属内
CELF5 Q8N6W0 PRR13 Homo sapiens Q9NZ81
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
32296183
种属内
CELF5 Q8N6W0 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
种属内
CELF5 Q8N6W0 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Specific Language Impairment

Language Impairment, Specific

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CELF5 VGNC VGNC:60747
Mus musculus CELF5 MGD MGI:2442333
Rattus norvegicus CELF5 RGD RGD:1565016
Canis familiaris CELF5 VGNC VGNC:39096
Bos taurus CELF5 VGNC VGNC:55204
Macaca mulatta CELF5 VGNC VGNC:109597