AATF - apoptosis antagonizing transcription factor Gene

中文名称：凋亡拮抗转录因子

种属: Homo sapiens

同用名: DED; BFR2; CHE1; CHE-1

关于 AATF

功能概要

由该基因编码的蛋白质是根据其与 MAP3K12/DLK 的相互作用而鉴定的，MAP3K12/DLK 是一种已知参与诱导细胞凋亡的蛋白激酶。该基因产物包含一个亮氨酸拉链，它是转录因子的特征基序，当与 Gal4 DNA 结合域融合时显示出强烈的反式激活活性。该基因的过表达干扰了 MAP3K12 诱导的细胞凋亡。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell Apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced Apoptosis. [provided by RefSeq, Jul 2008]