KAT2A - lysine acetyltransferase 2A Gene

中文名称：赖氨酸乙酰转移酶 2A

种属: Homo sapiens

同用名: GCN5; hGCN5; GCN5L2; PCAF-b

基因 ID: 2648 | 基因类型: protein coding

关于 KAT2A

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,113,111-42,121,367 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 11 paralogues. Ubiquitous expression in ovary (RPKM 41.6), adrenal (RPKM 30.6) and 25 other tissues.

功能概要

KAT2A 或 GCN5 是一种组蛋白乙酰转移酶 (HAT) ，主要用作转录激活剂。它还通过以独立于 HAT 的方式促进 NF-kappa-B 亚基 RELA (MIM 164014) 的泛素化来充当 NF-kappa-B 的阻遏物 (参见 MIM 164011) (Mao 等人，2009 [PubMed 19339690] ) .[OMIM 提供，2009 年 9 月]

KAT2A, or GCN5, is a Histone Acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

KAT2A 基因产物(3)

mRNA	Protein	Name
XM_006721818.5	XP_006721881.1	histone acetyltransferase KAT2A isoform X1
NM_021078.3	NP_066564.2	histone acetyltransferase KAT2A isoform 1
NM_001376227.1	NP_001363156.1	histone acetyltransferase KAT2A isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	17301242	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	29211711	GOA
enables histone H3 acetyltransferase activity	IDA IDA: 通过直接分析推断	18838386	GOA
enables histone H3K9 acetyltransferase activity	IDA IDA: 通过直接分析推断	21131905	GOA
enables histone acetyltransferase activity	IDA IDA: 通过直接分析推断	10373431	GOA
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	12887892	GOA
enables histone glutaryltransferase activity	IDA IDA: 通过直接分析推断	31542297	GOA
enables histone succinyltransferase activity	IDA IDA: 通过直接分析推断	29211711	GOA
enables peptide-lysine-N-acetyltransferase activity	IDA IDA: 通过直接分析推断	16753578	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17664281	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	11564863	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in internal peptidyl-lysine acetylation	IDA IDA: 通过直接分析推断	27796307	GOA
involved in negative regulation of centriole replication	IDA IDA: 通过直接分析推断	27796307	GOA
involved in negative regulation of gluconeogenesis	IDA IDA: 通过直接分析推断	16753578	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18838386	GOA
involved in peptidyl-lysine glutarylation	IDA IDA: 通过直接分析推断	31542297	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	29973595	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	29211711	GOA
involved in regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	19936620	GOA
involved in regulation of cell cycle	IMP IMP: 通过突变表型推断	19103755	GOA
involved in regulation of cell division	IDA IDA: 通过直接分析推断	20562830	GOA
acts upstream of or within regulation of protein stability	IMP IMP: 通过突变表型推断	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9603525	GOA
involved in regulation of tubulin deacetylation	IMP IMP: 通过突变表型推断	20562830	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of ATAC complex	IDA IDA: 通过直接分析推断	18838386	GOA
part of SAGA complex	IDA IDA: 通过直接分析推断	11564863	GOA
located in centrosome	IDA IDA: 通过直接分析推断	27796307	GOA
part of histone acetyltransferase complex	IDA IDA: 通过直接分析推断	29973595	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11564863	GOA
part of oxoglutarate dehydrogenase complex	IDA IDA: 通过直接分析推断	29211711	GOA
part of transcription factor TFTC complex	IDA IDA: 通过直接分析推断	10373431	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KAT2A 蛋白结构

PCAF_N

Acetyltransf_7

Bromodomain

0
200
400
600
837 a.a.

蛋白主名

其他名称

histone acetyltransferase KAT2A

GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2	General control of amino acid synthesis, yeast, homolog-like 2
K(lysine) acetyltransferase 2A	STAF97
general control of amino acid synthesis protein 5-like 2	histone acetyltransferase GCN5
histone glutaryltransferase KAT2A	histone succinyltransferase KAT2A
hsGCN5

KAT2A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Cross	KAT2A	Q92830	N	SARS-CoV-2	P0DTC9	Acetylase Assay	33894414
Intra	KAT2A	Q92830	ZZZ3	Homo sapiens	Q8IYH5	Anti Bait CoIP	20562830
Intra	KAT2A	Q92830	AATF	Homo sapiens	Q9NY61	Y2H	29232376
Intra	KAT2A	Q92830	WDHD1	Homo sapiens	O75717	Anti Bait CoIP	21725360

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Retinal Degeneration

Degeneration Of Retina

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome	Broad Thumb-Hallux Syndrome
Chromosome 16p13.3 Deletion Syndrome	Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion
Rubinstein Syndrome	Broad Thumbs-Halluces Syndrome
Rsts	Rubinstein-Taybi Deletion Syndrome
Rsts Deletion Syndrome	Proximal Chromosome 16p13.3 Deletion Syndrome
16p13.3 Deletion Syndrome	Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation
Rts

Spinocerebellar Ataxia 7

Spinocerebellar Ataxia Type 7	SCA7
Opca3	Opca Iii
Olivopontocerebellar Atrophy Iii	Opca With Retinal Degeneration
Opca With Macular Degeneration And External Ophthalmoplegia	Adca, Type Ii
Autosomal Dominant Cerebellar Ataxia Type 2	Olivopontocerebellar Atrophy 3
Autosomal Dominant Cerebellar Ataxia, Type Ii	Autosomal Dominant Cerebellar Ataxia Type Ii
Adca2	Adcaii
Ataxia With Pigmentary Retinopathy	Cerebellar Syndrome-Pigmentary Maculopathy Syndrome
Olivopontocerebellar Atrophy With Retinal Degeneration	Spinocerebellar Ataxia-7
Ataxia, Spinocerebellar, Type 7

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07074	KAT2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07075	Kat2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07076	Kat2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	KAT2A	RGD	RGD:1307242
Canis familiaris	KAT2A	VGNC	VGNC:42209
Felis catus	KAT2A	VGNC	VGNC:63023
Mus musculus	KAT2A	MGD	MGI:1343101
Bos taurus	KAT2A	VGNC	VGNC:30398
Others	KAT2A	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KAT2A - lysine acetyltransferase 2A Gene

关于 KAT2A

功能概要

KAT2A 基因产物(3)

KAT2A 蛋白结构

KAT2A 蛋白互作信息

关联疾病

直系同源

热门区域

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KAT2A - lysine acetyltransferase 2A Gene

关于 KAT2A

功能概要

KAT2A 基因产物(3)

KAT2A 蛋白结构

KAT2A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z