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  2. TADA2B - transcriptional adaptor 2B Gene

TADA2B - transcriptional adaptor 2B Gene

中文名称:转录衔接子 2B

种属: Homo sapiens

同用名: ADA2B; ADA2(beta)

基因 ID: 93624 | 基因类型: protein coding

关于 TADA2B

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:7,043,372-7,057,952 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 7.9) and 25 other tissues.

功能概要

TADA2B 作为一种转录衔接蛋白发挥作用,通过协调组蛋白乙酰转移酶 (HAT) 活性和将激活因子连接到基础转录机制来增强转录 (Barlev 等人,2003 [PubMed 12972612]) 。[OMIM 提供,2010 年 4 月]

TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of Histone Acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]

TADA2B 基因产物(1)

mRNA Protein Name
NM_152293.3 NP_689506.2 transcriptional adapter 2-beta
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
29232376 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SAGA-type complex IDA
IDA: 通过直接分析推断
18838386 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TADA2B 蛋白结构

ZZ

ZZ: Zinc finger, ZZ type (9 - 46)

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (68 - 110)

  • 0
  • 100
  • 200
  • 300
  • 420 a.a.
蛋白主名 其他名称

transcriptional adapter 2-beta

ADA2-beta

TADA2B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TADA2B Q86TJ2 AATF Homo sapiens Q9NY61
Y2H
29232376
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 7

Spinocerebellar Ataxia Type 7

SCA7

Opca3

Opca Iii

Olivopontocerebellar Atrophy Iii

Opca With Retinal Degeneration

Opca With Macular Degeneration And External Ophthalmoplegia

Adca, Type Ii

Autosomal Dominant Cerebellar Ataxia Type 2

Olivopontocerebellar Atrophy 3

Autosomal Dominant Cerebellar Ataxia, Type Ii

Autosomal Dominant Cerebellar Ataxia Type Ii

Adca2

Adcaii

Ataxia With Pigmentary Retinopathy

Cerebellar Syndrome-Pigmentary Maculopathy Syndrome

Olivopontocerebellar Atrophy With Retinal Degeneration

Spinocerebellar Ataxia-7

Ataxia, Spinocerebellar, Type 7

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TADA2B VGNC VGNC:107202
Mus musculus TADA2B MGD MGI:3035274
Felis catus TADA2B VGNC VGNC:65923
Rattus norvegicus TADA2B RGD RGD:1561605
Canis familiaris TADA2B VGNC VGNC:47071