2. Gene
  3. CAMK2G - calcium/calmodulin dependent protein kinase II gamma Gene

CAMK2G - calcium/calmodulin dependent protein kinase II gamma Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙/钙调蛋白依赖性蛋白激酶 II γ

种属: Homo sapiens

同用名: CAMK; CAMKG; MRD59; CAMK-II

基因 ID: 818 | 基因类型: protein coding

关于 CAMK2G

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,812,501-73,874,555 (from NCBI)

This gene has 27 transcripts (splice variants), 297 orthologues, 22 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 28.7), prostate (RPKM 10.9) and 24 other tissues.

功能概要

该基因的产物是属于丝氨酸/苏氨酸蛋白激酶家族和 CA (2+) /钙调蛋白依赖性蛋白激酶亚家族的酶的四个亚基之一。钙信号对于谷氨酸能突触可塑性的几个方面至关重要。在哺乳动物细胞中，酶由四种不同的链组成：α、β、γ 和 δ。该基因的产物是伽马链。已经描述了许多编码不同亚型的可变剪接转录本，但尚未确定所有变体的全长性质。[RefSeq 提供，2011 年 3 月]

The product of this gene is one of the four subunits of an Enzyme which belongs to the serine/threonine protein kinase family, and to the CA(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the Enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]

CAMK2G 基因产物(79)

mRNA Protein Name
XR_007061995.1
XM_047425798.1 XP_047281754.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3
NM_001367542.1 NP_001354471.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 35
XM_005270198.2 XP_005270255.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X4
NM_001367548.1 NP_001354477.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 41
NM_001367529.1 NP_001354458.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 22
NM_001367520.1 NP_001354449.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 13
XR_007061992.1
XM_047425805.1 XP_047281761.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X15
NM_001367547.1 NP_001354476.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 40
NM_001367524.1 NP_001354453.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 17
NM_001367516.1 NP_001354445.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 10
XR_001747218.2
NM_001367526.1 NP_001354455.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 19
XR_007061994.1
NM_001367540.1 NP_001354469.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 33
XR_007061999.1
NM_172172.1
NM_001367518.1 NP_001354447.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 11
XM_005270205.2 XP_005270262.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X10
XR_007062000.1
NM_172171.3 NP_751911.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1
XM_006717998.2 XP_006718061.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6
NR_160263.1
NM_001367539.1 NP_001354468.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 32
NM_001367538.1 NP_001354467.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 31
NM_001367535.1 NP_001354464.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 28
NM_001367522.1 NP_001354451.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 15
XR_007061998.1
NR_160046.1
XM_047425801.1 XP_047281757.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8
NM_001367534.1 NP_001354463.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 27
NR_160045.1
NM_001204492.2 NP_001191421.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7
NM_001367528.1 NP_001354457.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 21
NM_001367536.1 NP_001354465.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 29
NM_001320898.2 NP_001307827.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 8
NR_160044.1
NM_001367523.1 NP_001354452.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 16
XM_047425800.1 XP_047281756.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7
NM_001367533.1 NP_001354462.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 26
NM_172170.5 NP_751910.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3
XR_007061993.1
NM_001367532.1 NP_001354461.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 25
NM_001367543.1 NP_001354472.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 36
NM_001367531.1 NP_001354460.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 24
XR_007061996.1
NR_160040.1
NM_001367546.1 NP_001354475.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 39
XR_007061991.1
XM_006717996.2 XP_006718059.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2
XM_024448218.2 XP_024303986.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X9
XM_047425799.1 XP_047281755.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5
NM_001367527.1 NP_001354456.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 20
NM_001367517.1 NP_001354446.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3
NM_172173.3 NP_751913.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 6
NM_001367530.1 NP_001354459.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 23
NM_001367521.1 NP_001354450.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 14
XM_047425802.1 XP_047281758.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X12
XM_047425804.1 XP_047281760.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X14
XR_007061990.1
XM_047425803.1 XP_047281759.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13
XR_945821.2
XR_007061997.1
XM_017016730.2 XP_016872219.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11
NM_001367519.1 NP_001354448.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 12
NR_160041.1
NM_001367537.1 NP_001354466.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 30
NM_001367544.1 NP_001354473.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 37
NR_160047.1
NM_001367514.1 NP_001354443.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 9
XM_047425797.1 XP_047281753.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1
NM_001222.4 NP_001213.2 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 4
XR_945822.2
NM_172169.3 NP_751909.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2
NM_001367545.1 NP_001354474.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 38
NR_160042.1
NM_001367541.1 NP_001354470.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 34
NM_001367525.1 NP_001354454.1 calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 18
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20668654 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20668654 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
20668654 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of neuron projection development IMP
IMP: 通过突变表型推断
30184290 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calcium- and calmodulin-dependent protein kinase complex IDA
IDA: 通过直接分析推断
20668654 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CAMK2G 蛋白结构

Pkinase

Pkinase: Protein kinase domain (14 - 272)

CaMKII_AD

CaMKII_AD: Calcium/calmodulin dependent protein kinase II association domain (424 - 551)

  • 0
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  • 500
  • 556 a.a.
蛋白主名 其他名称

calcium/calmodulin-dependent protein kinase type II subunit gamma

caMK-II subunit gamma

calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma

CAMK2G 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CAMK2G Q13555 CAMK2D Homo sapiens Q13557
Anti Tag CoIP
35271311
Intra CAMK2G Q13555 CAMK2B Homo sapiens Q13554
Anti Tag CoIP
33961781
Intra CAMK2G Q13555 CAMK2D Homo sapiens Q13557
Pull Down
32707033
Intra CAMK2G Q13555 CAMK2G Homo sapiens Q13555
X-Ray Diffraction
20668654
Intra CAMK2G Q13555 CAMK2A Homo sapiens Q9UQM7
Anti Tag CoIP
33961781
Intra CAMK2G Q13555 CAMK2B Homo sapiens Q13554
Pull Down
32707033
Intra CAMK2G Q13555 ARHGAP29 Homo sapiens Q52LW3
Pull Down
32707033
Intra CAMK2G Q13555 CAMK2D Homo sapiens Q13557
Solution Sedimentation
20668654
Intra CAMK2G Q13555 CAMK2A Homo sapiens Q9UQM7
Pull Down
32707033
Intra CAMK2G Q13555 FKBP5 Homo sapiens Q13451
Pull Down
32707033
Intra CAMK2G Q13555 CAMK2G Homo sapiens Q13555
Solution Sedimentation
20668654
Intra CAMK2G Q13555 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra CAMK2G Q13555 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
22939624
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephronophthisis 11

NPHP11

Nephronophthisis, Type 11
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
Intellectual Developmental Disorder, Autosomal Dominant 59

MRD59

Mental Retardation, Autosomal Dominant 59
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1

Cadasil

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy

Casil

Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy

Familial Vascular Leukoencephalopathy

CADASIL1

Cadasil 1

Hereditary Multi-Infarct Dementia

Cadasil Syndrome

Dementia, Hereditary Multiinfarct Type

Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1

Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy

Dementia, Hereditary Multi-Infarct Type

Hereditary Dementia, Multi-Infarct Type

Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy

Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1

Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant

Dementia Hereditary Multiinfarct Type

Dementia Hereditary Multi-Infarct Type

Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01859 CAMK2G Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01860 Camk2g Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01861 CAMK2G Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CAMK2G VGNC VGNC:70525
Bos taurus CAMK2G VGNC VGNC:55982
Rattus norvegicus CAMK2G RGD RGD:621802
Felis catus CAMK2G VGNC VGNC:60334
Canis familiaris CAMK2G VGNC VGNC:38681
Mus musculus CAMK2G MGD MGI:88259
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