CD2 蛋白, Rat (HEK293, Fc)

CD2 Protein, a cell surface glycoprotein, mediates T-cell activation and adhesion by binding to its ligand, CD58. It facilitates immune responses and intercellular communication. CD2 Protein is a promising target for immunotherapy and may lead to innovative treatments for immune-related disorders. CD2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD2 protein, expressed by HEK293 , with C-hFc labeled tag.

CD2 蛋白通过与淋巴细胞功能相关抗原 CD58 (LFA-3) 和 CD48/BCM1 相互作用，在促进 T 细胞和各种细胞类型之间的粘附方面发挥着至关重要的作用。它还参与触发 T 细胞并通过其胞质结构域传递信号。此外，CD2 与 CD48、CD58 (LFA-3)、CD2AP 和 PSTPIP1 相互作用，表明它们可能参与相关的细胞过程。值得注意的是，CD2 和 FCGR3A 之间的相互作用可以调节 NK 细胞活化和细胞毒性。

Measured by its binding ability in a functional ELISA. Immobilized Rat CD2, at 2μg/mL (100μL/well) can bind Anti-CD2 antibody. The ED₅₀ for this effect is 1.486 μg/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Rat CD2, at 2μg/mL (100μL/well) can bind Anti-CD2 antibody. The ED₅₀ for this effect is 1.486 μg/mL.

Rat

HEK293

C-hFc

Q5I0M6 (R23-P202)

497761  [NCBI]

RDSGTVWGALGHGINLNIPNFQMTDDIDEVRWERGSTLVAEFKRKMKPFLKSGAFEILANGDLKIKNLTRDDSGTYNVTVYSTNGTRILNKALDLRILEMVSKPMIYWECSNATLTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWTNLRAPFKCKAVNRVSQESEMEVVNCPEKGLP

Approximately 57-75 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.