CD8 beta 蛋白, Human (HEK293)

CD8 beta is an important immune glycoprotein that serves as a coreceptor for MHC class I:peptide complexes, linking T cells to antigens presented by APCs. It interacts with TCR and MHC class I, recruits LCK kinase, and initiates multiple signaling pathways. CD8 beta Protein, Human (HEK293) is the recombinant human-derived CD8 beta protein, expressed by HEK293 , with tag free. The total length of CD8 beta Protein, Human (HEK293) is 170 a.a., with molecular weight of ~27.3 kDa.

CD8 β 是一种完整的膜糖蛋白，在免疫反应中发挥着关键作用，具有针对外部和内部威胁的多种功能。在 T 细胞中，其主要功能是作为 MHC I 类分子：肽复合物的辅助受体，其中 I 类肽呈递的抗原源自胞质蛋白。CD8 beta 同时与 T 细胞受体 (TCR) 和抗原呈递细胞 (APC) 呈递的 MHC I 类蛋白相互作用，将 Src 激酶 LCK 招募到 TCR-CD3 复合物附近。CD8B 链胞质尾部存在棕榈酰化位点，有利于 CD8 分配到质膜脂筏中，从而富集信号蛋白。一旦 LCK 被招募，它就会启动多种细胞内信号传导途径，磷酸化各种底物并导致淋巴因子的产生、运动、粘附和细胞毒性 T 淋巴细胞 (CTL) 的激活。CD8β 在 CD8+ T 细胞的胸腺选择中也发挥着关键作用。在细胞表面，它与 CD8A 形成二硫键连接的异二聚体，并与 CD3D 相互作用，将 TCR-CD3 与 CD8 偶联，还与 LCK 相互作用。

Human

HEK293

Tag Free

P10966-1 (L22-P170)

926  [NCBI]

Approximately 27.3 kDa

Greater than 85% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.