CD8B - CD8b molecule Gene

中文名称：CD8b 分子

种属: Homo sapiens

同用名: LY3; P37; LEU2; LYT3; Ly-3; CD8B1; CD8beta

关于 CD8B

功能概要

CD8 抗原是一种细胞表面糖蛋白，存在于大多数细胞毒性 T 淋巴细胞上，可介导免疫系统内有效的细胞间相互作用。作为辅助受体的 CD8 抗原和 T 淋巴细胞上的 T 细胞受体识别抗原呈递细胞 (APC) 在 I 类 MHC 分子中展示的抗原。功能性辅助受体是由两条α链组成的同型二聚体，或者是由一条α链和一条β链组成的异二聚体。 α 和 β 链都与免疫球蛋白可变轻链具有显着的同源性。该基因编码 CD8 β 链亚型。已经描述了编码不同膜相关或分泌同种型的多个可变剪接转录物变体。一个假基因也位于 2 号染色体上，已被鉴定。[RefSeq 提供，2010 年 5 月]

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]