DPYS 蛋白, Human (sf9, His-GST)

The DPYS protein plays a key role in the reductive pyrimidine degradation pathway by catalyzing the second step involving the reversible hydrolysis of dihydropyrimidines. Its enzymatic activity extends to the ring opening of 5,6-dihydrouracil, leading to the formation of N-carbamoyl-alanine, and the conversion of 5,6-dihydrothymine to N-carbamoyl-aminoisobutylene acid ester. DPYS Protein, Human (sf9, His-GST) is the recombinant human-derived DPYS protein, expressed by Sf9 insect cells , with N-GST, N-His labeled tag. The total length of DPYS Protein, Human (sf9, His-GST) is 519 a.a., with molecular weight of ~69 kDa.

二氢嘧啶酶（DPYS）是一种在还原嘧啶降解途径中发挥关键作用的酶，催化二氢嘧啶的可逆水解开环。具体来说，DPYS可以催化5,6-二氢尿嘧啶开环生成N-氨甲酰-丙氨酸和5,6-二氢胸腺嘧啶开环生成N-氨甲酰-氨基异丁酸酯。这种酶活性是嘧啶衍生物分解代谢的关键步骤，有助于核苷酸和核酸代谢物的分解。DPYS 在二氢嘧啶水解开环中的多功能性凸显了其在维持嘧啶稳态和细胞内嘧啶相关化合物的循环中的重要性。了解 DPYS 的功能有助于深入了解嘧啶代谢的调节及其对细胞过程的影响。参考资料：所提供的信息基于截至 2022 年 1 月的一般知识，未引用具体参考资料。

Human

Sf9 insect cells

N-GST;N-His

Q14117 (M1-P519)

1807  [NCBI]

Approximately 69 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.