Elafin/Trappin-2 蛋白, Human (HEK293, His)

Elafin/Trappin-2, a skin-specific inhibitor of neutrophil and pancreatic elastase, safeguards tissues against elastase-mediated proteolysis. Its inhibitory range extends to the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor. Elafin/Trappin-2 also weakly inhibits Kv11.1/KCNH2/ERG1 and transient receptor potential cation channel subfamily V member 1 (TRPV1), as reported in studies. Elafin/Trappin-2 Protein, Human (HEK293, His) is the recombinant human-derived Elafin/Trappin-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Elafin/Trappin-2 Protein, Human (HEK293, His) is 95 a.a., with molecular weight of 13-15 kDa.

Elafin/Trappin-2 被认为是一种中性粒细胞和胰腺弹性蛋白酶特异性抑制剂，主要存在于皮肤中，可作为针对弹性蛋白酶介导的组织蛋白水解的保护因子。它的抑制特性超越了蛋白酶，因为它已被证明能够抑制 alpha-4-beta-2/CHRNA2-CHRNB2 烟碱乙酰胆碱受体。此外，据研究记录，Elafin/Trappin-2 对 Kv11.1/KCNH2/ERG1 和瞬时受体电位阳离子通道亚家族 V 成员 1 (TRPV1) 具有微弱的抑制作用。

The inhibitory activity of the product has not been validated; activation with Cathepsin C may be required before product use.

Human

HEK293

C-6*His

P19957 (A23-Q117)

5266  [NCBI]

AVTGVPVKGQDTVKGRVPFNGQDPVKGQVSVKGQDKVKAQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ

13-15 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.