1. Gene
  2. PI3 - peptidase inhibitor 3 Gene

PI3 - peptidase inhibitor 3 Gene

中文名称:肽酶抑制因子 3

种属: Homo sapiens

同用名: ESI; WAP3; SKALP; WFDC14; cementoin

基因 ID: 5266 | 基因类型: protein coding

关于 PI3

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,174,902-45,176,544 (from NCBI)

This gene has 1 transcript (splice variant), 80 orthologues and 9 paralogues. Biased expression in esophagus (RPKM 578.7), colon (RPKM 50.5) and 1 other tissue.

功能概要

该基因编码一种弹性蛋白酶特异性抑制剂,可作为抗革兰氏阳性和革兰氏阴性细菌以及真菌病原体的抗菌肽。该蛋白质包含一个 WAP 型四二硫核心 (WFDC) 结构域,因此是 WFDC 结构域家族的成员。大多数 WFDC 基因成员位于染色体 20q12-q13 的两个簇中:着丝粒和端粒。该基因属于着丝粒簇。该基因的表达受细菌脂多糖和细胞因子的上调。[RefSeq 提供,2014 年 10 月]

This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and Fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by Bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]

PI3 基因产物(1)

mRNA Protein Name
NM_002638.4 NP_002629.1 elafin preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables structural constituent of skin epidermis IDA
IDA: 通过直接分析推断
7543090 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptide cross-linking IDA
IDA: 通过直接分析推断
7543090 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cornified envelope IDA
IDA: 通过直接分析推断
7543090 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PI3 蛋白结构

Cementoin

Cementoin: Trappin protein transglutaminase binding domain (31 - 47)

Cementoin

Cementoin: Trappin protein transglutaminase binding domain (55 - 71)

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (72 - 116)

  • 0
  • 100
  • 117 a.a.
蛋白主名 其他名称

elafin

PI-3

重组 PI3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70316 Elafin/Trappin-2 Protein, Human (HEK293, His) P19957 (A23-Q117) ≥95%

关联疾病

疾病名称 别名
Pustular Psoriasis
Farmer'S Lung

Farmer Lung

Farmers Lung

Farmer'S Lung Disease

Farmers' Lung

Farmers' Lung Disease

Mouldy Hay Disease

Moldy Hay Disorder

Fibrosis Of Lung With Farmers' Lung

Harvesters' Hypersensitivity Pneumonitis

Moldy Hay Pneumoconiosis

Haymakers' Hypersensitivity Pneumonitis

Threshers' Lung

Harvester Lung

Haymaker Lung

Extrinsic Allergic Alveolitis

Hypersensitivity Pneumonitis

Alveolitis, Extrinsic Allergic

Alveolitis

Allergic Interstitial Pneumonitis

Allergic Pneumonitis

Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis

Hp

Pneumonitis Hypersensitivity

Allergic Alveolitis

Extrinsic Allergic Alveolitis Nos

Airway Obstruction With Allergic Alveolitis

Unspecified Allergic Alveolitis And Pneumonitis

Extrinsic Allergic Bronchiolo-Alveolitis

Hypersensitivity Pneumonia

Hypersensitivity Pneumonitis Nos

Obstructive Lung Disease With Allergic Alveolitis

Obstructive Lung Disorder With Hypersensitivity Pneumonitis

Obstructive Lung Disorder With Allergic Alveolitis

Obstructive Lung Disease With Hypersensitivity Pneumonitis

Erysipelas
Adult Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome

Ards

Non-Cardiogenic Pulmonary Edema

Acute Lung Injury

Respiratory Distress Syndrome, Adult

Shock Lung

Acute Respiratory Distress

Respiratory Distress Syndrome

Adult Rds

Ali

Increased-Permeability Pulmonary Edema

Stiff Lung

Respiratory Distress Syndrome Adult

Impetigo
Netherton Syndrome

NETH

Ns

Netherton Disease

Comel-Netherton Syndrome

Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

Bamboo Hair Syndrome

Ichthyosis Linearis Circumflexa

Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

Ilc

Nts

N Syndrome

Allergic Contact Dermatitis

Dermatitis, Allergic Contact

Contact Dermatitis, Allergic

Dermatitis Allergic Contact

Allergic Contact Eczema

Acd - [Allergic Contact Dermatitis]

Allergic Contact Dermatitis, Unspecified Cause

Allergic Dermatitis

Allergic Eczema

Allergy Dermatitis

Allergy Eczema

Allergic Contact Eczema Due To Clothing Or Footwear

Perfume Allergic Contact Dermatitis

Allergic Contact Dermatitis Due To Cosmetics

Allergic Contact Eczema Due To Cosmetics Or Fragrances

Allergic Contact Eczema Due To Dental Materials

Allergic Contact Eczema Due To Food Flavours Or Additives

Allergic Contact Eczema Due To Hairdressing Products

Allergic Contact Eczema Due To Metals Or Metal Salts

Allergic Contact Eczema Due To Proteins

Allergic Contact Eczema Due To Plastics Or Resin Systems

Allergic Contact Eczema Due To Preservatives Or Biocides

Allergic Contact Eczema Due To Rubber Chemicals

Rubber Dermatitis

Allergic Contact Eczema Due To Systemic Medicaments

Allergic Contact Eczema Due To Topical Medicaments

Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung

Psoriasis
Corneal Abscess
Double Pterygium
Pasteurellosis

Pasteurella Infection

Pasteurella Infections

Pasteurella Infectious Disease

Shipping Fever

Transport Fever

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Familiar Ovarian Carcinoma
Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder

Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8

Iddm8

Insulin-Dependent Diabetes Mellitus 8

T1D8

Insulin-Dependent Diabetes Mellitus-8

Preterm Premature Rupture Of The Membranes

Preterm Premature Rupture Of Membranes

PPROM

Preterm Premature Rupture Of The Membranes, Susceptibility To

Pprom - [Preterm Premature Rupture Of Membranes]

Preterm Rupture Of Membranes

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease

COPD

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Chronic Obstructive Lung Disease

Chronic Obstructive Airway Disease

Pulmonary Disease, Chronic Obstructive, Susceptibility To

Cold

Severe Early-Onset Chronic Obstructive Pulmonary Disease

Pulmonary Disease Chronic Obstructive

Pulmonary Disease, Obstructive, Chronic, Susceptibility To

Chronic Obstructive Pulmonary Disease Of Horses

Common Cold

Upper Respiratory Infections

Copd - [Chronic Obstructive Pulmonary Disease]

Coad - [Chronic Obstructive Airways Disease]

Cold - [Chronic Obstructive Lung Disease]

Chronic Airway Disease Nos

Chronic Airways Limitation, Unspecified

Chronic Obstructed Airway, Unspecified

Chronic Obstructive Airway Disease, Unspecified

Chronic Obstructive Airway, Unspecified

Obstructive Lung Disease Nos

Chronic Obstructive Lung Disease Nos

Chronic Obstructive Lung Nos

Obstructive Pulmonary Disease Nos

Exacerbation Copd Nos

Acute Exacerbation Copd

Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland

Joubert Syndrome 7

JBTS7

Cerebello-Oculo-Renal Syndrome 3

Cors3

Joubert Syndrome, Type 7

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma