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  4. Doxazosin hydrochloride

Doxazosin hydrochloride  (Synonyms: 盐酸多沙唑嗪; UK 33274 hydrochloride)

目录号: HY-W753806
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摩尔计算器

Doxazosin hydrochloride (UK 33274 hydrochloride)是一种用于抑制高血压和前列腺增生的化合物，具有抑制血管平滑肌上突触后α1-肾上腺素受体的活性。Doxazosin hydrochloride可以导致血管扩张，从而降低外周血管阻力。Doxazosin hydrochloride在小鼠肝纤维化模型中被发现能够抑制肝星状细胞的增殖和迁移。Doxazosin hydrochloride通过激活PI3K/Akt/mTOR信号通路来调节肝星状细胞的纤维化、自噬和凋亡。Doxazosin hydrochloride还阻止自噬流并诱导肝星状细胞的凋亡。

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Doxazosin hydrochloride Chemical Structure

Doxazosin hydrochloride Chemical Structure

CAS No. : 70918-01-3

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Doxazosin hydrochloride 的其他形式现货产品:

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Doxazosin hydrochloride 相关抗体

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生物活性

Doxazosin hydrochloride (UK 33274 hydrochloride) is a compound used to inhibit hypertension and prostate hyperplasia, with activity that inhibits postsynaptic α1-adrenoceptors on vascular smooth muscle. Doxazosin hydrochloride can cause vasodilation, thereby reducing peripheral vascular resistance. Doxazosin hydrochloride was found to inhibit the proliferation and migration of hepatic stellate cells in a mouse liver fibrosis model. Doxazosin hydrochloride regulates fibrosis, autophagy, and apoptosis of hepatic stellate cells by activating the PI3K/Akt/mTOR signaling pathway. Doxazosin hydrochloride also blocks autophagic flux and induces apoptosis of hepatic stellate cells[1].

分子量

487.94

Formula

C23H26ClN5O5
CAS 号
中文名称

盐酸多沙唑嗪
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Doxazosin hydrochloride 相关分类

  • 摩尔计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doxazosin70918-01-3UK 33274盐酸多沙唑嗪UK33274UK-33274OthersInhibitorinhibitorinhibit

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